A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein

We have identified three yeast genes, KES1, HES1 and OSH1, whose products show homology to the human oxysterol binding protein (OSBP). Mutations in these genes resulted in pleiotropic sterol-related phenotypes. These include tryptophan-transport defects and nystatin resistance, shown by double and triple mutants. In addition, mutant combinations showed small but apparently cumulative reductions in membrane ergosterol levels. The three yeast genes are also functionally related as overexpression of HES1 or KES1 alleviated the tryptophan-transport defect in kes1Δ or osh1Δ mutants, respectively. Our study implicates this new yeast gene family in ergosterol synthesis and provides comparative evidence of a role for human OSBP in cholesterol synthesis.     

An electromigration failure model for interconnects under pulsedand bidirectional current stressing

An electromigration failure model which can be used to project the electromigration lifetime under pulsed DC and AC current stressing has been reported. The experimental results indicate that different metallization systems (Al-2%Si, Al4%Cu/TiW, and Cu) show similar failure behaviors, which can be explained and predicted by this model. The pulsed DC lifetime is found to be longer than DC lifetime, and the AC lifetime is found to be very much longer. This recognition can provide significant relief to circuit designs involving metals carrying pulsed DC and AC currents, and allow a more aggressive design to improve circuit density and speed     

HfOxNy的场发射特性

用直流溅射和高温退火相结合的方法制备了HfOxNy薄膜并测试了其场发射性能,发现其具有较低的开启电场、较大的发射电流密度以及很好的发射稳定性.高压"锻炼"对提高HfOxNy场发射性能起着关键作用,这与高压"锻炼"下薄膜内部结构和表面性质的改变有关.对场发射机理的研究表明,HfOxNy的场发射符合经典的FN隧穿理论.     

OPNET的网络仿真机制及仿真建模方法

随着计算机技术和通信技术的迅猛发展，网络仿真已成为时下研究、规划、设计网络不可缺少的工具。本文以OPNET为例，在系统研究OPNET网络仿真机制的基础上，着重探讨了OPNET的网络仿真建模方法。     

纳米技术及其在新材料领域中的应用与展望

本文对作为21世纪高新技术之一的纳米技术进行了阐述,并对其在新材料中的应用进行了阐述和展望。     

土质边坡稳定分析中条分法与有限元法的比较

对比分析了土质边坡稳定性计算中条分法和有限元法的特点，讨论了在有限元法中边坡稳定系数的计算方法，并针对铜钟水电站库区左岸滑坡分别采用条分法和有限元法研究其稳定性，计算结果表明两种计算方法得到的滑坡稳定系数规律相同，但条分法计算值一般大于有限元值，反映出条分法中部分基本假设与实际情况存在一定差异。     

基于媒体用户访问行为偏好模型的代理缓存算法

目前,代理缓存技术广泛应用于改善流媒体传输的服务质量.文章从实际用户日志文件的分析出发,利用发现的用户浏览流媒体对象时的行为分布模型,提出了一种新的视频流媒体缓存算法.仿真结果证明,该算法可以通过记录很少的用户访问信息获取较高的性能表现.     

智能化劳厄定向法

提出了晶体劳厄定向的智能化方法；简述了有关的Ｘ射线衍射理论、数学模型和运行步骤；讨论了该方法的可靠性和实用性．     

VAc—BA／MMA三元共聚物的制备及产品的粘接强度和聚合方法的关系

本文介绍了ＶＡｃ／ＢＡ／ＭＭＡ三元共聚的两种方法，并通过实验证实：聚合方法对三元共聚物的粘接强度有明显的影响。