3-N-丙酰基-2-芳基-5-(3-碘苯基)-1,3,4-(口恶)唑啉类化合物的合成及表征

以3-碘苯甲酸为原料,在浓硫酸作用下与乙醇反应制得3-碘苯甲酸乙酯(1),再以无水乙醇为溶剂,在105℃化合物1与80％的水合肼反应8 h,制得3-碘苯甲酰肼(2)。在无水乙醇中,在90～95℃化合物2分别与4-甲基苯甲醛、2-氯苯甲醛、4-氯苯甲醛、4-羟基苯甲醛、2,4-二氯苯甲醛、4-甲氧基苯甲醛、3-硝基苯甲醛、4-硝基苯甲醛和4-二甲氨基苯甲醛反应得到相应的酰腙[3(a～i)]。最后化合物3(a～i)分别与丙酸酐脱水环化成了3-N-丙酰基-2-芳基-5-(3-碘苯基)-1,3,4-(口恶)唑啉类化合物[4(a～i)],收率分别为86．2％,70．5％, 80．1％,68．2％,62．4％,75．2％,73．2％,70．5％和63．2％。并通过元素分析,IR,1H NMR和MS对化合物4(a～i)的结构进行了表征。     

大体积承台混凝土施工

阐述了东莞水道特大桥主桥承台大体积混凝土浇筑施工工艺 ,及施工中的注意事项 ,从分层的厚度、表面处理等方面 ,提出了采用泵送混凝土浇筑施工中质量弊病的预防措施     

Preparation and Characterization of Carboxymethyl Chitosan and β-Cyclodextrin Microspheres by Spray Drying

Three kinds of carboxymethyl chitosan/β-cyclodextrin microspheres loaded with theophylline were prepared by spray drying intended for pulmonary delivery. Mucociliotoxicity, permeation rate, and drug release characteristics of the product were investigated. The microspheres obtained by spray drying were found to be spherical with smooth or wrinkled surfaces. The mean particle size was between 3.39 and 6.06 µm. The microspheres demonstrated high product yield (43.7-50.2%), high drug loading (13.7-38.1%), and high encapsulation efficiency (86.9-92.8%). FT-IR indicated that there were interactions of theophylline with carboxymethyl chitosan matrix. Further studies on mucociliotoxicity and permeation confirmed that microspheres had better adaptability and high permeation rate. In vitro drug release from the microspheres was not related to the drug/polymer ratios.     

Syntheses and Structural Characterization of Triorganotin Derivatives of Bis(carboxymethyl)trithiocarbonate: X-ray Crystal Structures of 2D Network Polymers

Six triorganotin(IV) complexes of the type {(R₃Sn)₂[C₃S₃(COO)₂]}_n (R = C₆H₅ 1; n-Bu 2; PhCH₂ 4; p-F-PhCH₂ 5; o-F-PhCH₂ 6) and {(R₃Sn)₂[C₃S₃(COO)₂]}_n·[EtOH] (R = Me 3) have been synthesized by the reaction of bis(carboxymethyl)trithiocarbonate with triorganotin(IV) chloride in the presence of sodium ethoxide. All complexes were characterized by elemental analysis IR, ¹H, ¹³C and ¹¹⁹Sn NMR spectroscopy. Except for 4–6, all complexes were also characterized by X-ray crystallography. The X-ray date revealed that complexes 1–3 show two-dimensional network polymeric structure in which the geometries of tin atoms are trigonal bipyramid with the axial positions occupied by carboxylic oxygen atoms.     

Hydrothermal Synthesis of Magnesium Aluminate Platelets

Magnesium aluminate (MgAl₂O₄) platelets were first synthesized by hydrothermal treatment of γ-AlO(OH) in a magnesium nitrate aqueous solution at 400°C. The platelets are 100–200 nm in width and 25 nm in thickness. The influence of temperature, the anions of the magnesium salt, the amount of magnesium salt, and precursor pH on the formation of such structure was investigated. The experimental results indicated that the anions of the magnesium salt and precursor pH could have a significant influence on the growth of MgAl₂O₄. MgAl₂O₄ formation followed the in situ transformation mechanism, which was the reason why the MgAl₂O₄ crystallites had a platelet morphology.     

Synthesis of Hexagonal‐Phase NaYF4:Yb,Er and NaYF4:Yb,Tm Nanocrystals with Efficient Up‐Conversion Fluorescence

IR‐to‐visible up‐conversion fluorescent nanocrystals of hexagonal‐phase NaYF₄:20 %Yb,2 %Er and NaYF₄:20 %Yb,2 %Tm have been synthesized by decomposition of multiprecursors of CF₃COONa, (CF₃COO)₃Y, (CF₃COO)₃Yb, and (CF₃COO)₃Er/(CF₃COO)₃Tm in oleylamine at 330 °C. The average particle size is 10.5 ± 0.7 nm (from random measurements of 200 particles from five transmission electron microscopy images) and 11.1 ± 1.3 nm (from dynamic‐light‐scattering measurements). The up‐conversion fluorescence intensity of the hexagonal nanocrystals in this work is much higher than that of other cubic‐phase NaYF₄:Yb,Er nanocrystals, including the ones in this work (by a factor of 7.5). Mechanisms for nucleation and growth of the hexagonal‐phase nanoparticles are proposed. These nanocrystals are easily dispersed in organic solvents, producing a transparent colloidal solution. The hydrophobic surfaces of the particles are made hydrophilic using a bipolar surfactant. These nanoparticles and their dispersions in various media have potential applications in optical nanodevices and bioprobes.     

基于MapInfo的西气东输管线地理信息系统的研究

讨论了西气东输管线空间数据库的建立过程，并以该空间数据库为后台利用MapInfo公司的GIS组件MapX进行二次开发，实现了全数字化的输气管道信息的存储与查询，使输气管线信息化管理更加现代化。     

灌区参与式管理存在的问题与对策

参与式灌溉管理是我国正在推广应用的灌区管理模式，本文通过对我国目前已实行参与式灌溉管理灌区的运行情况的调查，简单阐述了这种管理模式的绩效，着重分析了管理运行过程中存在的问题，并提出了解决这些问题的措施和建议。     

LonWorks总线在锅炉模糊控制系统中的应用

采用LonWorks总线技术可以提高锅炉控制系统燃烧效率及可靠性、保证环保要求、降低成本、优化网络的热量分配。尤其多台锅炉通过LON总线联网运行能够合理分配负荷,从而达到提高工作效率的目的。     

七里河市区段河道整治工程规划设计的实践与思考

我国有不少城市有河流穿过，市区段河道整治工程有防洪和美化城市双重功能，鉴于朔州市七里河河道整治工程的实践，笔者认为，市区段河道整治工程规划必须与城市总体规划布局相适应，工程设计在坚固耐用的同时应突出美观新颖，如果兴建水库，应在河道上游设置报汛机构，确保水库正常运行，还可以发挥市区土地价格高的优势，裁弯取直，回填土方，新增土地，筹措建设资金，体现以人为本、可持续发展、构建和谐社会的水利建设要求，将影响市容市貌的弯曲扭折的河道，变为城市中一道亮丽的风景线。