Intraocular concentrations of chemotherapeutic agents after systemic or local administration

OBJECTIVES: To investigate the concentrations of carboplatin and etoposide achieved in the aqueous and vitreous humors after intravenous infusion in nonhuman primates, and to investigate whether local administration of carboplatin might result in higher concentrations in the vitreous humor. METHODS: Macaca fascicularis primates were treated with 1 of 3 regimens: (1) intravenous carboplatin (18.7 mg/kg), etoposide (5 mg/kg), and vincristine sulfate (0.05 mg/kg), (2) peribulbar carboplatin (10 mg/mL), or (3) episcleral balloon carboplatin (10 mg/mL). Concentrations of chemotherapeutic agents were measured in the plasma and in the aqueous and vitreous humors. RESULTS: No measurable amount of etoposide was detected in the aqueous or vitreous humor after intravenous administration. Mean measured peak vitreous concentration of carboplatin after intravenous administration was 0.31 microg/mL, which was 1% of the peak plasma value. Mean measured peak vitreous concentrations of carboplatin after peribulbar or episcleral balloon administration were 2.38 microg/mL and 2.95 microg/mL, respectively, which represent 7.68- and 9.52-fold increases over the concentration achieved after intravenous administration. No serious toxic effect was observed in any animal. CONCLUSIONS: Peribulbar and episcleral balloon administration of carboplatin seemed to be safe and resulted in higher vitreous concentrations than intravenous administration in this model. These results suggest that these alternate routes of delivery should be explored in children with vitreous seeding of retinoblastoma.     

本钢烧结矿冷却及其余热回收的试验研究

从烧结矿冷却并回收其余热的角度出发，介绍了利用烧结机尾落矿空间，采用喷吹空气装置对烧结矿进行冷却的小型模拟试验，从测出的结果来看，有可能成为一种新的烧结矿冷却方式。     

连续流动分析仪应用于水中硫化物的测定

对连续流动法测定硫化物进行初步探讨和研究。同时与其他几种测定硫化物的方法进行了比较。实验结果表明，连续流动法对硫化物分析在线性、稳定性、最低检测限、准确性和精密度等方面均优于其他方法。     

In situ synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology

A novel processing technology was developed to investigate in situ synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology. Thermodynamic analysis was performed to predict possible starting materials and synthesizing conditions of TiC-Al (Ti) nanocomposite powders. A mathematical model was developed to describe temperature profile and velocity distribution in the reactor. The model is applied to optimize feeding rate, input power, and other processing parameters of TiC-Al (Ti) nanocomposite powders by thermal plasma technology, and to predict which materials can be used as starting materials. This paper emphasizes the investigation of the effect of feeding rate, input power, mole ratio, and other process parameters on synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology. The experimental results showed that TiC-Al (Ti) nanocomposite powders can be synthesized in situ by thermal plasma technology, and the average size of TiC-Al (Ti) nanocomposite powders was less than 100 nm.     

试论当代中国邪教的基本特征及其防范措施

在论述邪教基本内涵的基础上,着重从五个方面分别阐述了当代中国邪教的基本特征及其防范的主要措施.     

单嘴精炼装置真空室内卷渣水模型研究

本文针对长城特殊厂单嘴精炼装置进行了真空室内加渣精炼的卷渣水模型研究。在试验的基础上，首先讨论了真空室内卷渣现象的工艺过程，然后进一步得出了临界吹气量的表达式。研究结果为工业性生产进一步提高钢的质量打下了基础。     

Nonparametric change detection and estimation in large-scale sensor networks

The problem of detecting changes in the distribution of alarmed sensors is considered. Under a nonparametric change detection framework, several detection and estimation algorithms are presented based on the Vapnik-Chervonenkis (VC) theory. Theoretical performance guarantees are obtained by providing error exponents for false-alarm and miss detection probabilities. Recursive algorithms for the efficient computation of test statistics are derived. The estimation problem is also considered in which, after detection is made, the location with maximum distribution change is estimated.     

基于波动方程的聚焦点控制照明叠前深度偏移

 基于波动方程的聚焦点控制照明叠前深度偏移技术借助于差分计算，把速度、密度等介质参数的影响体现在差分计算的矩阵方程中，能够自动适应速度场的任意变化，快速傅里叶变换的使用也加速了波场延拓的计算速度。因此此法兼具有限差分偏移方法和傅里叶偏移方法的优点，既可适应速度场的剧烈变化，又可保证对陡倾地层的成像效果，是目前针对复杂构造最有效的成像方法之一。对于单个聚焦点及其周围的成像步骤为：①采用矩形网格情况下绕射走时的有限差分计算方法生成合成算子；②应用合成算子来合成面炮震源和面波记录；③对合成的面炮震源和面波记录做傅里叶有限差分法波动方程叠前深度偏移，得到该聚焦点及其附近区域的成像结果。按照上述成像步骤，将震源波场和炮集记录依据相应的外推公式进行延拓，最终应用成像条件求取成像值。在地质目标处选取多个聚焦点，可以得到面向目标的控制照明偏移成像，在多个层位上选取多个聚焦点进行控制照明叠前深度偏移，可以得到整块区域的成像。通过对Marmousi模型的试算，取得了较好的效果。     

开发计算机管理信息系统推动设备供应管理现代化

本文介绍了我国冶金大型钢铁联合企业设备供应管理系统计算机应用开发过程及研制方法，并分析了取得的经济效益和在国内的推广价值。     

基于自组织神经网络的实时统计特征抽取方法

应用人工神经网络讨论统计了特征抽取的原理，提出了相应的抽取方法。该方法具有实时性，容错性，高数据压缩率和良好的特征分辨率。通过计算机仿真和桥梁索力状态的实例计算分析证实了该技术具有广泛的应用价值。