Integrable multimode interference distributed Bragg reflector laser all-optical flip-flops

A novel fully integrable all-optical flip-flop has been created using distributed Bragg reflector multimode interference bistable laser diodes. The single metal-organic vapor phase epitaxy regrowth offset quantum well structure active/passive integrated flip-flop lases in single mode at 1554 nm and is compatible with standard fabrication methods of InP photonic integrated circuits (PICs). All-optical reset switching through cross-gain saturation was demonstrated over a 52-nm range, at 1522-1574 nm. An optical set has been achieved with -3 dBm and optical reset with less than -5-dBm external light injection. The flip-flop will be useful for integration in PICs of future photonic systems for self-routing and optical memories or buffers.     

Development of smart composite structures with small-diameter fiber Bragg grating sensors for damage detection: Quantitative evaluation of delamination length in CFRP laminates using Lamb wave sensing

The authors and Hitachi Cable, Ltd. have recently developed small-diameter optical fiber and its fiber Bragg grating (FBG) sensor for embedment inside a lamina of composite laminates without strength reduction. The outside diameters of the cladding and polyimide coating are 40 and 52 μm, respectively. First, a brief summary is presented for applications of small-diameter FBG sensors to damage monitoring in composite structures. Then, we propose a new damage detection system for quantitative evaluation of delamination length in CFRP laminates using Lamb wave sensing. In this system, a piezo-ceramic actuator generates Lamb waves in a CFRP laminate. After the waves propagate in the laminate, transmitted waves are received by an FBG sensor attached on or embedded in the laminate using a newly developed high-speed optical wavelength interrogation system. This system was applied to detect interlaminar delamination in CFRP cross-ply laminates. When the Lamb waves passed through the delamination, the amplitude decreased and a new wave mode appeared. These phenomena could be well simulated using a finite element analysis. From the changes in the amplitude ratio and the arrival time of the new mode depending on the delamination length, it was found that this system could evaluate the delamination length quantitatively. Furthermore, small-diameter FBG sensors were embedded in a double-lap type coupon specimen, and the debonding progress could be evaluated using the wavelet transform.     

Plan for first phase of safety demonstration tests of the High Temperature Engineering Test Reactor (HTTR)

Safety demonstration tests using the High Temperature Engineering Test Reactor (HTTR) will be conducted for the purpose of demonstrating inherent safety features of High Temperature Gas-cooled Reactors (HTGRs) as well as providing the core and plant transient data for validation of HTGR safety analysis codes. The first phase safety demonstration test items include the reactivity insertion test and the coolant flow reduction test. In the reactivity insertion test, which is the control rod withdrawal test, one pair out of 16 pairs of control rods is withdrawn, simulating a reactivity insertion event. The coolant flow reduction test consists of the partial loss of coolant flow test and the gas circulators trip test. In the partial loss of coolant flow test, primary coolant flow rate is slightly reduced by control system. In the gas circulators trip test one and two out of three gas circulators are run down, simulating coolant flow reduction events. The gas circulators trip tests, in which position of control rods are kept unchanged, are simulation tests of anticipated transients without scram (ATWS).     

Interior permanent magnet linear synchronous motor forhigh-performance drives

Permanent magnet linear synchronous motors have been developed for factory automation, transportation applications, and so on. In the rotary-type permanent magnet synchronous machines, the wide speed and constant power operation are realized by using the reluctance torque due to the saliency and the flux-weakening control. In this paper, we examine the effect of the interior permanent magnet arrangement for wide speed operation and the end effect in the linear structure     

General structure and characteristics of quick response production system

The diversification and shorter production cycles urge manufacturers to shift their production systems from “make to stock” to “make to order” or an intermediate production system between them. The present paper deals with a production system developed by some manufacturers to meet requirements in the last decade. The system, which we call “Quick response to orders production system” or in brief “quick response production system (QRPS)”, is characterized by two key factors, i.e., “acceptable response time” and “semifinished product.” An acceptable response time is decided through the explicit or implicit approval of customers beforehand and manufacturers guarantee to ship products within an acceptable response time in a stochastic sense by processing the semifinished product according to customer order. As a result, manufacturers are able to reduce the inventory of finished products, while customers are able to enjoy the diversification of products and a stable supply from manufacturers. The general structure and characteristics of QRPS are discussed primarily from a quantitative point of view and a numerical example is shown to assist in understanding the design and operation of QRPS.     

Legacy system program transformation by Lyee methodology

Based on the comparative review of several approaches to legacy system conversion and revitalization, the Lyee methodology application for the issue is presented to clarify its idea, the associated procedure, and the implemented tools. It could be said that with the tools and manual developed by ICBSM&T, the mechanical transformation of the conventional program to a Lyee-structured one becomes possible as long as the programs are made in a procedure-oriented language. In addition to the program structure conversion, the Lyee methodology permits people to choose any application language in the transformed program. At the same time, quite a new approach related to the system conversion is introduced, in which the chunk of data extracted from an old program is edited to make a new conventional structure program that has a logical sequence instead of a Lyee type of declarative program. These features can be realized through the concept of LyeeBELT, which is a set of word-information about the attributes, formulae, and conditions for an independent data item.

The overall workflow of the legacy program transformation is shown in the following.

A critical part in its implementation is the feasibility study (pre-analysis) stage where necessary information is supposed to be secured, and an appropriate plan and policy about the system to be revitalized in the new system environment should be clarified so as to customize the tools accordingly. If the initial process is completed, the mechanical legacy system conversion will be realized by registering the parameters in the tool, and the reestablishment of business knowledge in the LyeeBELT will be enabled. With the regulated business logic on the LyeeBELT, the program maintenance afterwards becomes drastically simplified and stable without the ‘spaghetti’ problem, so that software evolution can be possible.     

Semantic Web: A road to the knowledge infrastructure on the internet

In this article, I describe the basic technologies for Semantic Web and relationship between Semantic Web and Knowledge Representation in Artificial Intelligence. Semantic Web is planned as an extension of the current web in order to help cooperation between computers and humans, i.e., computers and humans are expected to understand each other in the knowledge level. I first describe the vision of the Semantic Web, then introduce the current Semantic Web technologies, i.e., RDF, RDFS, and OWL. I describe relationship between the trend of Semantic Web and Knowledge Representation, and clarify challenges and difficulties of Semantic Web from the point of view of Knowledge Representation. Hideaki Takeda: He is a professor at National Institute of Informatics (NII) and a professor in Department of Informatics at the Graduate University of Advanced Studies (Sokendai). He received his Ph.D. from the University of Tokyo in 1991. His research interest in computer science includes ontology engineering, community informatics and knowledge sharing systems.     

A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin,from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells

The seed oil of Carapa guianensis Aublet (Andiroba) has been used in folk medicine for its insect-repelling, anti-inflammatory, and anti-malarial activities. This study aimed to examine the triglyceride (TG) reducing effects of C. guianensis-derived limonoids or other commercially available limonoids in human hepatoblastoma HepG2 cells and evaluate the expression of lipid metabolism or autophagy-related proteins by treatment with 7-deacetoxy-7-oxogedunin (DAOG; 1), a principal limonoid of C. guianensis. The gedunin-type limonoids, such as DAOG (% of control at 20 μM: 70.9 ± 0.9%), gedunin (2, 74.0 ± 1.1%), epoxyazadiradione (4, 73.4 ± 2.0%), 17β-hydroxyazadiradione (5, 79.9 ± 0.6%), 7-deacetoxy-7α-hydroxygedunin (6, 61.0 ± 1.2%), andirolide H (7, 87.4 ± 2.2%), and 6α-hydroxygedunin (8, 84.5 ± 1.1%), were observed to reduce the TG content at lower concentrations than berberine chloride (BBR, a positive control, 84.1 ± 0.3% at 30 μM) in HepG2 cells pretreated with high glucose and oleic acid. Andirobin-, obacunol-, nimbin-, and salannin-type limonoids showed no effect on the intracellular TG content in HepG2 cells. The TG-reducing effect of DAOG was attenuated by the concomitant use of compound C (dorsomorphin), an AMPK inhibitor. Further investigation on the detailed mechanism of action of DAOG at non-cytotoxic concentrations revealed that the expressions of autophagy-related proteins, LC3 and p62, were upregulated by treatment with DAOG. These findings suggested that gedunin-type limonoids from Andiroba could ameliorate fatty liver, and that the action of DAOG in particular is mediated by autophagy.     

Macrophage Activation Markers Predict Liver-Related Complications in Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) has a wide variation in clinical presentation and course. There is no significant correlation between these symptoms and the disease stage, although patients with more advanced stages generally have more symptoms. It is important to develop biomarkers in order to identify patients with an increased risk of complications and end-stage liver disease. This study investigated surrogate markers for risk estimation of PBC-related complications, including a study population of 77 patients with PBC who underwent liver biopsy and were measured for serum levels of macrophage activation markers, soluble CD163 (sCD163), soluble mannose receptor (sMR), and zonulin. Patients with PBC were divided into symptomatic (Group S, n = 20) and asymptomatic (Group A, n = 57) groups. The correlations of histological stages based on both Scheuer and Nakanuma classifications with the three serum markers were investigated. The Nakanuma classification involves grading for liver fibrosis and bile duct loss. The three biomarkers were assessed for their diagnostic ability to identify patients with PBC having high risk of developing complications. The predictive factors of these complications were examined as well. Group S had significantly higher serum sMR (p = 0.011) and sCD163 (p = 0.048) levels versus Group A. A composite index of sMR and sCD163 measurements had significantly better prediction performance than sCD163 alone (p = 0.012), although not when compared to sMR alone (p = 0.129). Serum sMR was an independent factor for developing complications on both univariate (Odds ratio (OR) = 30.20, 95% confidence interval (95% CI): 3.410–267.0, p = 0.00220), and multivariate (OR = 33.70, 95% CI: 3.6600–311.0, p = 0.0019) analyses. Patients with PBC having sMR of ≥56.6 had a higher incidence of clinical complications versus those with a sMR of <56.6. Serum sMR predicts the development of complications in patients with PBC. sMR plus sCD163 showed better predictive power than either marker alone, although the addition of sCD163 did not improve the predictive power of sMR. Future prospective studies are required in order to validate the findings of the present study.