Change point detection algorithms have numerous applications in areas of medical condition monitoring, fault detection in industrial processes, human activity analysis, climate change detection, and speech recognition. We consider the problem of change point detection on compositional multivariate data (each sample is a probability mass function), which is a practically important sub-class of general multivariate data. While the problem of change-point detection is well studied in univariate setting, and there are few viable implementations for a general multivariate data, the existing methods do not perform well on compositional data. In this paper, we propose a parametric approach for change point detection in compositional data. Moreover, using simple transformations on data, we extend our approach to handle any general multivariate data. Experimentally, we show that our method performs significantly better on compositional data and is competitive on general data compared to the available state of the art implementations.
Objective: This work describes the application of natural plant polysaccharide as pharmaceutical mucoadhesive excipients in delivery systems to reduce the clearance rate through nasal cavity.Methods: Novel natural polysaccharide (Hibiscus rosasinensis)-based mucoadhesive microspheres were prepared by using emulsion crosslinking method for the delivery of rizatriptan benzoate (RB) through nasal route. Mucoadhesive microspheres were characterized for different parameters and nasal clearance of technetium-99m (99mTc)-radiolabeled microspheres was determined by using gamma-scintigraphy.Results: Their Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) studies showed that the drug was stable during preparation of microspheres. Aerodynamic diameter of microspheres was in the range 13.23?±?1.83–33.57?±?3.69?µm. Change in drug and polysaccharide ratio influenced the mucoadhesion, encapsulation efficiency and in-vitro release property. Scintigraphs taken at regular interval indicate that control solution was cleared rapidly from nasal cavity, whereas microspheres showed slower clearance (p?0.005) with half-life of 160?min.Conclusion: Natural polysaccharide-based microspheres achieved extended residence by minimizing effect of mucociliary clearance with opportunity of sustained delivery for longer duration. 相似文献
A good statistical model of speckle formation is useful for designing a good adaptive filter for speckle reduction In ultrasound B-scan images. Previously, statistical models have been used, but they failed to account for the log compression of the echo envelope employed by clinical ultrasound systems. Log-compression helps in reducing the dynamic range of the B-scan Images for display on a monitor as well as enhancing weak backscatters. In this article, statistics of log-compressed echo images, using the K-distribution statistical model for the echo envelope, are used to derive a parameter that can be used to quantify the extent of speckle formation. This speckle quantification can be used with an unsharp masking filter to adaptively reduce speckle. The effectiveness of the filter is demonstrated on images of contrast detail phantoms and on in-vivo abdominal images obtained by a clinical ultrasound system with log-compression. 相似文献
With the rapid growth of the availability and popularity of interpersonal and behavior-rich resources such as blogs and other social media avenues, emerging opportunities and challenges arise as people now can, and do, actively use computational intelligence to seek out and understand the opinions of others. The study of collective behavior of individuals has implications to business intelligence, predictive analytics, customer relationship management, and examining online collective action as manifested by various flash mobs, the Arab Spring (2011) and other such events. In this article, we introduce a nature-inspired theory to model collective behavior from the observed data on blogs using swarm intelligence, where the goal is to accurately model and predict the future behavior of a large population after observing their interactions during a training phase. Specifically, an ant colony optimization model is trained with behavioral trend from the blog data and is tested over real-world blogs. Promising results were obtained in trend prediction using ant colony based pheromone classier and CHI statistical measure. We provide empirical guidelines for selecting suitable parameters for the model, conclude with interesting observations, and envision future research directions. 相似文献
In this paper, we have developed analytical stochastic communication technique for inter and intra-Networks-on-Chip (NoC)
communication. It not only separates the computation and communication in Networks-in-Package (NiP) but also predicts the
communication performance. Moreover, it will help in tracking of the lost data packets and their exact location during the
communication. Further, the proposed technique helps in building the Closed Donor Controlled Based Compartmental Model, which
helps in building Stochastic Model of NoC and NiP. This model helps in computing the transition probabilities, latency, and
data flow from one IP to other IP in a NoC and among NoCs in NiP. From the simulation results, it is observed that the transient
and steady state response of transition probabilities give state of data flow latencies among the different IPs in NoC and
among the compartments of NoCs in NiP. Furthermore, the proposed technique produces low latency as compared to the latencies
being produced by the existing topologies. 相似文献
Nanocrystalline lanthanum strontium manganite (LSM) powder has been synthesized by combustion of a transparent gel obtained by the polymerization of methylol urea and urea in a solution containing La3+, Sr2+, and Mn2+ (LSM ions). Chemistry of the transparent urea–formaldehyde (UF) polymer gel formation and structure of the gel have been proposed such that the LSM ions act in between the growing UF polymer chains by interacting through NH, OH, and CO groups by co-ordination and prevent polymer self-assembly through inter-chain hydrogen bonding as evidenced from infrared spectrum. Thermally stable structures formed by the decomposition of UF polymer below 300°C undergo combustion in the presence of nitrate oxidant in a temperature range from 350°–450°C. A perovskite LSM phase has been formed by self-sustained combustion of the dried gel initiated with little kerosene. The powder obtained after deagglomeration and calcination at 600°C for 2 h has a D 50 value of 0.19 μm, and the particles are aggregates of crystallites 10–25 nm in size. 相似文献
We address the problem of reconstructing a surface from irregularly spaced sparse and noisy range data while concurrently identifying and preserving the significant discontinuities in depth. It is well known that, starting from either the probabilistic Markov random field model or the mechanical membrane or thin plate model for the surface, the solution of the reconstruction problem can be eventually reduced to the global minimization of a certain “energy” function. Requiring the preservation of depth discontinuities makes the energy function nonconvex and replete with multiple local minima. We present a new method for obtaining discontinuity-preserving reconstruction based on the numerical solution of an appropriate Ito vector stochastic differential equation (SDE). The reconstructed surface is found by following the sample path of the (stochastic) diffusion process that solves the SDE in question. Our central contribution is the demonstration of the efficacy of the stochastic differential equation technique for solving a vision problem. Through comparisions of the results of our method to those of the two well-known existingglobalminimization based reconstruction techniques, we show a significant improvement in the final reconstructions obtained. 相似文献
The paper presents a binary relational analysis and expert system base module for maintenance and fault diagnosis of CNC wire
EDM. The module proposes a framework of integrated maintenance and fault diagnosis system. The study explores the binary coded
matrix system, which plays an important role in prediction and diagnosis of wire electrical discharge machining (WEDM) faults
on the spot by expert guidance. In this study, 15 inputs were considered to observe eight probable causes with the help of
the forward and backward propagation algorithms. Inputs and output matrices were considered in the form of a square matrix.
To explain the fault diagnosis and to realize the importance of maintenance through advice, the detection of faults is investigated
through forward and back propagation of matrix transformation on the spot. It is an integrated backup that can be individually
focused when input and output parameter do not match. It is a time saving, knowledge acquisition, easy to maintain, and capable
of self-learning system. To verify the developed framework, 120 data sets were generated for proper analyzing of acquired
output through graphical representation. The paper also presents some of the important features of maintenance schedule and
probable causes of wire breakage with remedial actions in tabular form. The developed system can help the operators, trainees,
and manufacturing engineers in achieving trouble free machining through quick detection of faults and proper maintenance of
machines in actual practice. 相似文献
The article describes a novel approach to estimate and calibrate column water vapour (CWV), a key parameter for atmospheric correction of remote-sensing data. CWV is spatially and temporally variable, and image-based methods are used for its inference. This inference, however, is affected by methodological and numeric limitations, which likely propagate to reflectance estimates. In this article, a method is proposed to estimate CWV iteratively from target surface reflectances. The method is free from assumptions for at sensor radiance-based CWV estimation methods. We consider two cases: (a) CWV is incorrectly estimated in a processing chain and (b) CWV is not estimated in a processing chain. To solve (a) we use the incorrect estimations as initial values to the proposed method during calibration. In (b), CWV is estimated without initial information. Next, we combined the two scenarios, resulting in a generic method to calibrate and estimate CWV. We utilized the hyperspectral mapper (HyMap) and airborne prism experiment (APEX) instruments for the synthetic and real data experiments, respectively. Noise levels were added to the synthetic data to simulate real imaging conditions. The real data used in this research are cloud-free scenes acquired from the airborne campaigns. For performance assessment, we compared the proposed method with two state-of-the-art methods. Our method performed better as it minimizes the absolute error close to zero, only within 8–10 iterations. It thus suits existing operational chains where the number of iterations is considerable. Finally, the method is simple to implement and can be extended to address other atmospheric trace gases. 相似文献