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81.
This paper explores a hybrid wavelet, bootstrap and neural network (WBNN) modeling approach for daily (1, 3 and 5 day) urban water demand forecasting in situations with limited data availability. This method was tested using 3 years of daily water demand and meteorological data for the city of Calgary, Alberta, Canada. The performance of the WBNN method was compared to that of three other methods: traditional neural networks (NN), wavelet NNs (WNN), and bootstrap-based NN (BNN) models. While the hybrid WBNN and WNN models equally provided 1-day lead-time forecasts of greater accuracy than those obtained with other methods, for longer lead-time (3- or 5-day) forecasts the WBNN model alone outperformed the other models. The confidence bands generated using the WBNN model displayed the uncertainty associated with the forecasts. 相似文献
82.
A lot of research on nanomaterials has been carried out in recent years. However, there is still a lack of nanostructures that have a combination of superior properties; both efficient electron transport and high surface area. Here, the authors have tried to develop hybrid α-Fe(2)O(3) flower-like morphology which exhibits both superior electron transport and high surface area. Intrigued by the unique properties of Fe(2)O(3) at the nanoscale and its abundance in nature, we have demonstrated a facile template-free solution based synthesis of hybrid α-Fe(2)O(3) comprising nanopetals nucleating radially from a 3D core. Due to its simplicity, the synthesis process can be easily reproduced and scaled up. We carried out in-depth studies on gas sensing and dye-sensitized solar cell (DSSC) device characterization so as to gain an understanding of how surface area and transport properties are affected by variation in morphology. The hybrid α-Fe(2)O(3) nanostructures are studied as potential candidates for gas sensors and for the first time as a working electrode for DSSC. 相似文献
83.
Antagonism of microRNA function in zebrafish embryos by using locked nucleic acid enzymes (LNAzymes) 总被引:1,自引:0,他引:1
Suryawanshi H Lalwani MK Ramasamy S Rana R Scaria V Sivasubbu S Maiti S 《Chembiochem : a European journal of chemical biology》2012,13(4):584-589
MicroRNAs (miRNAs) have crucial functions in many cellular processes, such as differentiation, proliferation and apoptosis; aberrant expression of miRNAs has been linked to human diseases, including cancer. Tools that allow specific and efficient knockdown of miRNAs would be of immense importance for exploring miRNA function. Zebrafish serves as an excellent vertebrate model system to understand the functions of miRNAs involved in a variety of biological processes. We designed and employed a strategy based on locked nucleic acid enzymes (LNAzymes) for in vivo knockdown of miRNA in zebrafish embryos. We demonstrate that LNAzyme can efficiently knockdown miRNAs with minimal toxicity to the zebrafish embryos. 相似文献
84.
85.
Jaiswal MK Mallers TM Larsen B Kwak-Kim J Chaouat G Gilman-Sachs A Beaman KD 《Reproduction (Cambridge, England)》2012,143(5):713-725
Various mechanisms exist to prevent a potentially deleterious maternal immune response that results in compromising survival of semiallogeneic fetus. In pregnancy, there is a necessary early preimplantation inflammatory stage followed by a postimplantation anti-inflammatory stage. Thus, there is a biphasic 'immune response' observed during the course of pregnancy. We provide the evidence that capacitation of sperm induced the expression of a2 isoform of V-ATPase (ATP6V0A2 referred to as a2V), leukemia inhibitory factor (Lif), Il1b, and Tnf in the sperm. Capacitated sperm also released cleaved N-terminal domain of a2V-ATPase (a2NTD), which upregulates the gene expression of Lif, Il1b, Tnf, and monocyte chemotactic protein-1 (Ccl2 (Mcp1)) in the uterus. Unfertilized eggs had low a2V expression, but after fertilization, the expression of a2V increased in zygotes. This increased level of a2V expression was maintained in preimplantation embryos. Seminal plasma was necessary for upregulation of a2V expression in preimplantation embryos, as mating with seminal vesicle-deficient males failed to elicit an increase in a2V expression in preimplantation embryos. The infiltration of macrophages into the uterus was significantly increased after insemination of both sperm and seminal plasma during the preimplantation period of pregnancy. This dynamic infiltration into the uterus corresponded with the uterine a2V expression through the induction of Ccl2 expression. Furthermore, the polarization ratio of M1:M2 (pro-inflammatory/anti-inflammatory) macrophages in the uterus fluctuated from a ratio of 1.60 (day 1) to 1.45 (day 4) when female mice were inseminated with both sperm and seminal plasma. These data provide evidence that exposure to semen may initiate an inflammatory milieu by inducing a2V and cytokine/chemokine expression, which triggers the influx of macrophages into the preimplantation uterus during the onset of pregnancy and ultimately leads to successful pregnancy outcome. 相似文献
86.
P. C. Mukesh Kumar J. Kumar R. Tamilarasan S. Sendhil Nathan S. Suresh 《Journal of Mechanical Science and Technology》2014,28(5):1841-1847
In this experimental investigation, the heat transfer and pressure drop analysis of a shell and helically coiled tube heat exchanger by using Al2O3 / water nanofluids have been carried out under turbulent flow condition. The Al2O3/ water nanofluids of 0.1%, 0.4%, and 0.8% particle volume concentration have been prepared by using two step method. The tube side experimental Nusselt number of 0.1%, 0.4% and 0.8% nanofluids were found to be 28%, 36% and 56%, respectively higher than water. These enhancements are due to higher thermal conductivity of nanofluid, better fluid mixing and strong secondary flow formation in coiled tube. The pressure drop of 0.1%, 0.4% and 0.8% were found to be 4%, 6%, and 9%, respectively higher than water. The increase in pressure drop is due to increase in nanofluid viscosity while adding nanoparticles. The measurement of nanofluid thermal performance factor is found to be greater than unity. It is concluded that the Al2O3 nanofluid can be applied as a coolant in helically coiled tube heat exchanger to enhance heat transfer with negligible pressure drop. 相似文献
87.
Naidu BS Pandey M Sudarsan V Ghatak J Vatsa RK 《Journal of nanoscience and nanotechnology》2011,11(4):3180-3190
Nano-ribbons and very small nanoparticles (size 2-5 nm) of SbPO4 doped with lanthanide ions (Ce3+ and Tb3+) are prepared at a relatively low temperature of 120 degrees C based on a solution method. Detailed vibrational and luminescence studies on these samples establish that these lanthanide ions are incorporated at Sb3+ site of the SbPO4 lattice. The excitation spectrum corresponding to the Tb3+ emission and the excited state lifetime of the 5D4 level of Tb3+ ions in the sample confirm the energy transfer from Ce3+ to Tb3+ ions in the SbPO4 host. The extent of energy transfer from Ce3+ to Tb3+ in these samples is found to be around 60%. Dispersion of these nanomaterials in silica matrix effectively shields the lanthanide ions at the surface of the nano-ribbons/nanoparticles from the stabilizing ligands resulting in the reduction in the vibronic quenching of the excited state. Our results show significant reduction in the surface contribution in the decay curve corresponding to the 5D4 level of the Tb3+ ions after incorporating the nano-ribbons/nanoparticles in silica. These nanomaterials incorporated in silica matrix can have potential applications in bio-assays and bio-imaging. 相似文献
88.
89.
Mukesh K. Pandey Rahul Tyagi Ke Yang Clark K. Colton Virinder S. Parmar Eric Aiazian 《Polymer》2011,52(21):4727-4735
Since decades, varieties of amphiphilic polymers have been widely investigated for improving aqueous solubility and bioavailability of the hydrophobic drugs. The upcoming approach is to develop more efficient advanced nano-carrier molecules capable of more than drug delivery. Herein, we report the design and synthesis of some novel carrier molecules with multiple applications including drug encapsulation, drug delivery and diagnosis (imaging). Copolymers were synthesized using dimethyl 5-hydroxy/aminoisophthalate, poly(ethylene glycols) and Candida antarctica lipase (CAL-B, Novozym 435). CAL-B selectively catalyses the trans esterification reaction under solvent less condition using primary hydroxyls of poly(ethylene glycols) and leaving behind phenolic hydroxyl for post polymerization modifications. The obtained copolymers were further tethered with perfluorinated aliphatic chains to make them amphiphilic. The synthesized materials were investigated for their micellar behavior, temperature dependent stability (in aqueous solution), encapsulation capacity, and imaging potential by measuring the sensitivity of these perfluorinated materials towards 19F NMR in NMR tube. It was observed that perfluorinated amphiphilic copolymers could encapsulate up to 14% (by wt) of hydrophobic drug and showed decent 19F NMR signals even at a very low concentration. Therefore, these perfluorinated copolymers hold considerable potential for further investigation as advanced nano-carrier molecules for biomedical applications. 相似文献
90.
Total 360 samples (of 8 h each) of PM2.5 were collected from six sampling sites for summer and winter seasons in Kanpur city, India. The collected PM2.5 mass was subjected to chemical speciation for: (1) ionic species (NH+ 4, SO2– 4, NO– 3, and Cl–), (2) carbon contents (EC and OC), and (3) elemental contents (Ca, Mg, Na, K, Al, Si, Fe, Ti, Mn, V, Cr, Ni, Zn, Cd, Pb, Cu, As, and Se). Primary and secondary components of PM2.5 were assessed from speciation results. The influence of marine source to PM2.5 was negligible, whereas the contribution of crustal dust was significant (10% in summer and 7% in winter). A mass reconstruction approach for PM2.5 could distinctly establish primary and secondary components of measured PM2.5 as: (1) Primary component (27% in summer and 24% in winter): crustal, elemental carbon, and organic mass, (2) Secondary component (45% in summer and 50% in winter): inorganic and organic mass, and (3) others: unidentified mass (27% in summer and 26% in winter). The secondary inorganic component was about 34% in summer (NH+ 4: 9%; SO2– 4: 16%; NO– 3: 9%) and 32% in winter (NH+ 4: 8%; SO2+ 4: 13%; NO– 3: 11%). The secondary organic component was 12% in summer and 18% in winter. In conclusion, secondary aerosol formation (inorganic and organic) accounted for significant mass of PM 2.5 (about 50%) and any particulate control strategy should also include control of primary precursor gases. 相似文献