A multiscale parallel computing architecture for automated segmentation of the brain connectome

Several groups in neurobiology have embarked into deciphering the brain circuitry using large-scale imaging of a mouse brain and manual tracing of the connections between neurons. Creating a graph of the brain circuitry, also called a connectome, could have a huge impact on the understanding of neurodegenerative diseases such as Alzheimer's disease. Although considerably smaller than a human brain, a mouse brain already exhibits one billion connections and manually tracing the connectome of a mouse brain can only be achieved partially. This paper proposes to scale up the tracing by using automated image segmentation and a parallel computing approach designed for domain experts. We explain the design decisions behind our parallel approach and we present our results for the segmentation of the vasculature and the cell nuclei, which have been obtained without any manual intervention.     

Polycarbonate films metalized with a single component molecular conductor suited to strain and stress sensing applications

The paper reports all-organic strain and stress sensitive films that use electrical monitoring approach. The films were prepared by self-metallizing polycarbonate films with the single component molecular conductor [Au(α-tpdt)₂]⁰ (tpdt = 2,3-thiophenedithiolate). It was shown that [Au(α-tpdt)₂]⁰ by its nature is able to form metallic solid material with low crystallinity. Electromechanical tests demonstrated that the developed films are strain-resistive materials with advanced elastic properties: their electrical resistance varies linearly with uniaxial elongation up to relative strain being of 1.0% that is about five times larger than that for conventional metals. The gauge factor of the films is 4.4 and stress sensitivity is 30 Ω/bar. The processing characteristics of polycarbonate films, self-metalized with a metallic [Au(α-tpdt)₂]⁰-based layer, make them potentially useful for engineering flexible, lightweight, strain and pressure sensors. Due to electromechanical characteristics these films are suited to strain sensing applications requiring miniature strain control in a wide deformation range.     

西班牙毛革两用服装革加工理论及工艺技术应用

通过系统介绍具有国际领先水平的西班牙毛革两用服装革的加工原理及工艺技术应用 ,具体阐明了其漫长而复杂的生产流程 ,以及每道工序应如何做和这样做的理论依据。强调以绵羊皮为原料加工生产毛革两用服装革鞣制前脱脂的重要性。只有前期好的脱脂 ,才有好的鞣制 ,最终才有所要的理想的各种产品风格。     

西班牙毛革两用服装革加工理论及工艺技术应用(续)

通过系统介绍具有国际领先水平的西班牙毛革两用服装革的加工原理及工艺技术应用 ,具体阐明了其漫长而复杂的生产流程 ,以及每道工序应如何做和这样做的理论依据。强调以绵羊皮为原料加工生产毛革两用服装革鞣制前脱脂的重要性。只有前期好的脱脂 ,才有好的鞣制 ,最终才有所要的理想的各种产品风格。     

Key role of the resin layer thickness in the lability of complexes measured by DGT

Analysis of the dynamic features of diffusion gradients in thin film devices (DGT) indicates that the penetration of complexes into the resin layer dramatically increases their lability. This should be taken into account when interpreting DGT measurements in terms of the dynamics of solution speciation. The experimental accumulation of Cd by DGT sensors in Cd-NTA systems confirmed these theoretical analyses. A computational code, which allows a rigorous digital simulation of the diffusion-reaction processes in the gel and resin layers, was used to model the results and to demonstrate the effect of the complex penetration into the resin layer on the lability degree. These findings suggest that DGT renders all complexes much more labile than if the resin-diffusive gel interface was considered as a perfect planar sink, explaining why DGT often measures a high proportion of the metal in a natural water. This information is relevant since some studies have stressed the importance of labile complexes as a source of bioaccumulated metal.     

Formation of giant protein vesicles by a lipid cosolvent method

This paper describes a method to create giant protein vesicles (GPVs) of ≥10 μm by solvent-driven fusion of large vesicles (0.1-0.2 μm) with reconstituted membrane proteins. We found that formation of GPVs proceeded from rotational mixing of protein-reconstituted large unilamellar vesicles (LUVs) with a lipid-containing solvent phase. We made GPVs by using n-decane and squalene as solvents, and applied generalized polarization (GP) imaging to monitor the polarity around the protein transmembrane region of aquaporins labeled with the polarity-sensitive probe Badan. Specifically, we created GPVs of spinach SoPIP2;1 and E. coli AqpZ aquaporins. Our findings show that hydrophobic interactions within the bilayer of formed GPVs are influenced not only by the solvent partitioning propensity, but also by lipid composition and membrane protein isoform.     

Stability and performance analysis of networks supporting elasticservices

We consider the stability and performance of a model for networks supporting services that adapt their transmission to the available bandwidth. Not unlike real networks, in our model, connection arrivals are stochastic, each has a random amount of data to send, and the number of ongoing connections in the system changes over time. Consequently, the bandwidth allocated to, or throughput achieved by, a given connection may change during its lifetime as feedback control mechanisms react to network loads. Ideally, if there were a fixed number of ongoing connections, such feedback mechanisms would reach an equilibrium bandwidth allocation typically characterized in terms of its “fairness” to users, e.g., max-min or proportionally fair. We prove the stability of such networks when the offered load on each link does not exceed its capacity. We use simulation to investigate performance, in terms of average connection delays, for various fairness criteria. Finally, we pose an architectural problem in TCP/IPs decoupling of the transport and network layer from the point of view of guaranteeing connection-level stability, which we claim may explain congestion phenomena on the Internet