Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence?

Lipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery. Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects after demolitive or conservative breast cancer surgery and different procedures have been developed to improve the survival of transplanted fat graft. The regenerative potential of LF is attributed to the multipotent stem cells found in large quantity in adipose tissue. However, a growing body of pre-clinical evidence shows that adipocytes and adipose-derived stromal cells may have pro-tumorigenic potential. Despite no clear indication from clinical studies has demonstrated an increased risk of cancer recurrence upon LF, these observations challenge the oncologic safety of the procedure. This review aims to provide an updated overview of both the clinical and the pre-clinical indications to the suitability and safety of LF in breast oncological surgery. Cellular and molecular players in the crosstalk between adipose tissue and cancer are described, and heterogeneous contradictory results are discussed, highlighting that important issues still remain to be solved to get a clear understanding of LF safety in breast cancer patients.     

On requirement verification for evolving Statecharts specifications

Software development processes have been evolving from rigid, pre-specified, and sequential to incremental, and iterative. This evolution has been dictated by the need to accommodate evolving user requirements and reduce the delay between design decision and feedback from users. Formal verification techniques, however, have largely ignored this evolution and even when they made enormous improvements and found significant uses in practice, like in the case of model checking, they remained confined into the niches of safety-critical systems. Model checking verifies if a system’s model \(\mathcal{M}\) satisfies a set of requirements, formalized as a set of logic properties \(\Phi\) . Current model-checking approaches, however, implicitly rely on the assumption that both the complete model \(\mathcal{M}\) and the whole set of properties \(\Phi\) are fully specified when verification takes place. Very often, however, \(\mathcal{M}\) is subject to change because its development is iterative and its definition evolves through stages of incompleteness, where alternative design decisions are explored, typically to evaluate some quality trade-offs. Evolving systems specifications of this kind ask for novel verification approaches that tolerate incompleteness and support incremental analysis of alternative designs for certain functionalities. This is exactly the focus of this paper, which develops an incremental model-checking approach for evolving Statecharts. Statecharts have been chosen both because they are increasingly used in practice natively support model refinements.     

Effect of Enameling on the Strength and Dynamic Fatigue of Soda–Lime–Silica Float Glass

The effect of a glass enamel coating on the strength and fatigue behavior of float glass was investigated. Commercially available enamel that was comprised of Cu₂Cr₂O₄ pigment particles in a bismuth-zinc borosilicate glass matrix was applied to a soda–lime–silica float glass via screen printing, followed by fusion at elevated temperature. Strengths of the enameled specimens were evaluated in biaxial flexure using a ring-on-ring (ROR) test geometry, and the data were analyzed using a conventional two-parameter Weibull distribution. Enameling was found to significantly degrade the strength of the float glass. There was no statistical difference in the characteristic strengths of samples enameled on the air side (66 MPa) compared with samples enameled on the tin side (61 MPa) of the float glass. Fractographic analysis revealed that the failures in the enameled float glass samples initiated at pores and pigment aggregates in the enamel, whereas failures in float glass samples initiated solely from surface flaws. Dynamic fatigue tests were performed on enameled float glass and indented float glass samples to determine the effect of the enamel on the stress corrosion behavior of the enameled components. There was no statistically significant difference between the stress corrosion exponents for the float glass and enameled float glass specimens.     

Practical and theoretical molecular weights in polyaddition reactions of ethylene and propylene oxide

The addition reactions of ethylene oxide and/or propylene oxide catalyzed by KOH and initiated with compounds containing free hydroxyls are followed by secondary reactions which vary the expected molecular weight. By using ethylene oxide, diols are formed and by using propylene oxide, both diols and unsaturated monofunctional compounds are formed. These products are usually characterized by their hydroxyl number. The average molecular weight is found by taking into consideration the starter functionality only. There are often some behavioral differences among similar products owing to the different quantity and chain length of the secondary products contained therein. The secondary products are analyzed and the quantity of the secondary products were determined from the hydroxyl number values and from the unsaturation of reagents and products. In the case of monofunctional adducts using the calculation method, the results have been experimentally confirmed.     

Lecithin-protein interaction in the GTP-dependent acyl-CoA synthase

The enzymic activity of the GTP-dependent acyl-CoA synthase isolated from rat liver mitochondria is affected by removal and addition of lecithin (3). Purified preparations of this enzyme contain bound lecithin. In this presentation the nature of the lecithin-protein interaction is examined. From binding measurements at different temperatures it is possible to postulate which type of secondary valence bonds is holding the protein and lecithin together. Presented at AOCS Meeting, Chicago, October 1967.     

Effects of acid leaching treatment of soda-lime silicate glass on crack initiation and fracture

Water or acid soaking surface treatments have been shown to increase the mechanical strength of soda-lime silicate (SLS) glasses. This increase in strength has traditionally been attributed to effects related to residual stress or changes in fracture resistance. In this work, we report experimental data that cannot be explained based on the existing knowledge of glass surface mechanics. In dry environments, annealed and acid-leached SLS surfaces have comparable crack initiation stress and fracture stress as measured by Hertzian indentation and biaxial bending tests, respectively. Yet, in the presence of humidity, acid-leached surfaces have higher failure stress than the annealed surfaces. This apparent enhancement in the crack resistance of the acid-leached surface of SLS glass in humid environments supports the hypothesis that acid-leached surface chemistry can lower the transport kinetics of molecular water to critical flaws.     

Mocking Ads through Mobile Web Services

The need for creativity is ubiquitous, and mobile devices connected to Web services can help us. Linguistic creativity is widely used in advertisements to surprise us, to get our attention, and to stick concepts in our memory. However, creativity can also be used as a defense. When we walk in the street, we are overwhelmed by messages that try to get our attention with any persuasive device at hand. As messages get ever more aggressive, often our basic cognitive defenses—trying not to perceive those messages—are not sufficient. One advanced defensive technique is based on transforming the perceived message into something different (for instance, making use of irony or hyperbole) from what was originally meant in the message. In this article, we describe an implemented application for smartphones, which creatively modifies the linguistic expression in a virtual copy of a poster encountered on the street. The mobile system is inspired by the subvertising practice of countercultural art.     

Recommending multimedia visiting paths in cultural heritage applications

The valorization and promotion of worldwide Cultural Heritage by the adoption of Information and Communication Technologies represent nowadays some of the most important research issues with a large variety of potential applications. This challenge is particularly perceived in the Italian scenario, where the artistic patrimony is one of the most diverse and rich of the world, able to attract millions of visitors every year to monuments, archaeological sites and museums. In this paper, we present a general recommendation framework able to uniformly manage heterogeneous multimedia data coming from several web repositories and to provide context-aware recommendation techniques supporting intelligent multimedia services for the users—i.e. dynamic visiting paths for a given environment. Specific applications of our system within the cultural heritage domain are proposed by means of real case studies in the mobile environment related both to an outdoor and indoor scenario, together with some results on user’s satisfaction and system accuracy.     

Conceptual aspects of geometric quantum computation

Geometric quantum computation is the idea that geometric phases can be used to implement quantum gates, i.e., the basic elements of the Boolean network that forms a quantum computer. Although originally thought to be limited to adiabatic evolution, controlled by slowly changing parameters, this form of quantum computation can as well be realized at high speed by using nonadiabatic schemes. Recent advances in quantum gate technology have allowed for experimental demonstrations of different types of geometric gates in adiabatic and nonadiabatic evolution. Here, we address some conceptual issues that arise in the realizations of geometric gates. We examine the appearance of dynamical phases in quantum evolution and point out that not all dynamical phases need to be compensated for in geometric quantum computation. We delineate the relation between Abelian and non-Abelian geometric gates and find an explicit physical example where the two types of gates coincide. We identify differences and similarities between adiabatic and nonadiabatic realizations of quantum computation based on non-Abelian geometric phases.