Towards locally and globally shape-aware reverse 3D modeling

The process of re-creating CAD models from actual physical parts, formally known as digital shape reconstruction (DSR) is an integral part of product development, especially in re-design. While, the majority of current methods used in DSR are surface-based, our overarching goal is to obtain direct parameterization of 3D meshes, by avoiding the actual segmentation of the mesh into different surfaces. As a first step towards reverse modeling physical parts, we extract (1) locally prominent cross-sections (PCS) from triangular meshes, and (2) organize and cluster them into sweep components, which form the basic building blocks of the re-created CAD model. In this paper, we introduce two new algorithms derived from Locally Linear Embedding (LLE) (Roweis and Sauk, 2000 [3]) and Affinity Propagation (AP) (Frey and Dueck, 2007 [4]) for organizing and clustering PCS. The LLE algorithm analyzes the cross-sections (PCS) using their geometric properties to build a global manifold in an embedded space. The AP algorithm, then clusters the local cross sections by propagating affinities among them in the embedded space to form different sweep components. We demonstrate the robustness and efficiency of the algorithms through many examples including actual laser-scanned (point cloud) mechanical parts.     

Modeling and Simulation of Variable-Reluctance Step Motors with Application to a High-Performance Printer System

Basic information on modeling and digital computer simulation of variable-reluctance (VR) step motors is provided. The nonlinear equations of the system are derived, and a method for implementing them on a digital computer is presented. As an example, a typical printer with a step motor is designed with this approach. The problem is defined by giving the desired system performance criteria and the step motor parameters and characteristics. The specification of the control schemes determined the design. Computer simulation runs are made to determine the optimal control parameters of the system. The case study demonstrates the advantages of the computer-aided design, before the physical construction of the experimental system.     

Predicting Future Antisocial Personality Disorder in Males From a Clinical Assessment in Childhood.

It is essential to identify childhood predictors of adult antisocial personality disorder (APD) to target early prevention. It has variously been hypothesized that APD is predicted by childhood conduct disorder (CD), attention-deficit/hyperactivity disorder (ADHD), or both disorders. To test these competing hypotheses, the authors used data from a single childhood diagnostic assessment of 163 clinic-referred boys to predict future APD during early adulthood. Childhood Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; American Psychiatric Association, 1987) CD, but not ADHD, significantly predicted the boys' subsequent APD. An interaction between socioeconomic status (SES) and CD indicated that CD predicted APD only in lower SES families, however. Among children who met criteria for CD, their number of covert but not overt CD symptoms improved prediction of future APD, controlling for SES. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Formation of Quasicrystals and Related Structures in Systems of Aluminum with Transition Metals. Part 1. Binary Systems Formed by Aluminum with 3d Metals

Quasiperiodic phases (quasicrystals) with symmetries forbidden by classic crystallography have been observed in systems of aluminum with transition metals. In binary systems, these phases are metastable; they were obtained for the first time by rapid solidification of melts. We consider the formation of the quasicrystals and we refine the phase diagrams for binary systems A – 3d-M (from V to Ni) in which quasicrystals have been observed.     

Microscopy under pressure--an optical chamber system for fluorescence microscopic analysis of living cells under high hydrostatic pressure

High hydrostatic pressure (HHP) becomes more and more interesting for life science research, since it can be employed to inactivate various cells. To directly monitor "cells under pressure," the development of an optical high-pressure chamber is required. Therefore, an optical pressure chamber that can be used for up to 300 MPa was constructed. This chamber has already been described as a tool for in situ observation of dynamic changes of microscopic structures in bright field as well as phase contrast. In combination with an inverted microscope, we obtained brilliant microscopic color pictures with an optical resolution more than 0.56 microm. Here, we demonstrate the capabilities of the HHP cell, in combination with epifluorescence microscopy. Using a nonadherent human B-cell line (Raji, ATCC CCL 86), stained with the fluorescent dyes propidium iodide, Hoechst 33342, or dihexyloxacarbocyanine iodide, we were able to show that the system is suitable to perform fluorescence microscopic analyses, with pressures up to 300 MPa, with viable mammalian cells.     

Fitting in and feeling fine: Conformity and coping motives as mediators of the relationship between social anxiety and problematic drinking.

The present research was conducted to clarify the relationships among social anxiety, alcohol consumption, alcohol-related problems, and negative-reinforcement drinking motives among college students. Heavy drinking students (N = 316, 53.80% female) completed self-report measures of social anxiety, alcohol consumption, alcohol-related problems, and drinking motives. Findings indicated that students higher in social anxiety consumed less alcohol but experienced more negative consequences. Moreover, the relationship between social anxiety and negative consequences was mediated by coping and conformity drinking motives in addition to alcohol consumption. In the context of social anxiety, the current research demonstrates the importance of examining problematic drinking as distinct constructs: alcohol consumption and negative consequences. Findings are also discussed in terms of implications for interventions with socially anxious students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

利用汉字二元语法关系解决汉语自动分词中的交集型歧义

本文提出了一种利用句内相邻之间的互信息及ｔ－测试差这两个统计量解决汉语自动分词中交集型歧义切分字段的方法。初步的实验结果显示，可以正确处理９０．３％的交集字段。     

Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis

Systemic sclerosis (SSc) is characterised by progressive multiple organ fibrosis leading to morbidity and mortality. Lysyl oxidases play a vital role in the cross-linking of collagens and subsequent build-up of fibrosis in the extracellular matrix. As such, their inhibition provides a novel treatment paradigm for SSc. A novel small molecule pan-lysyl oxidase inhibitor, PXS-5505, currently in clinical development for myelofibrosis treatment was evaluated using in vivo rodent models resembling the fibrotic conditions in SSc. Both lysyl oxidase and lysyl oxidase-like 2 (LOXL2) expression were elevated in the skin and lung of SSc patients. The oral application of PXS-5505 inhibited lysyl oxidase activity in the skin and LOXL2 activity in the lung. PXS-5505 exhibited anti-fibrotic effects in the SSc skin mouse model, reducing dermal thickness and α-smooth muscle actin. Similarly, in the bleomycin-induced mouse lung model, PXS-5505 reduced pulmonary fibrosis toward normal levels, mediated by its ability to normalise collagen/elastin crosslink formation. PXS-5505 also reduced fibrotic extent in models of the ischaemia-reperfusion heart, the unilateral ureteral obstruction kidney, and the CCl4-induced fibrotic liver. PXS-5505 consistently demonstrates potent anti-fibrotic efficacy in multiple models of organ fibrosis relevant to the pathogenesis of SSc, suggesting that it may be efficacious as a novel approach for treating SSc.     

Photothermal self-oscillation and laser cooling of graphene optomechanical systems

By virtue of their low mass and stiffness, atomically thin mechanical resonators are attractive candidates for use in optomechanics. Here, we demonstrate photothermal back-action in a graphene mechanical resonator comprising one end of a Fabry-Perot cavity. As a demonstration of the utility of this effect, we show that a continuous wave laser can be used to cool a graphene vibrational mode or to power a graphene-based tunable frequency oscillator. Owing to graphene's high thermal conductivity and optical absorption, photothermal optomechanics is efficient in graphene and could ultimately enable laser cooling to the quantum ground state or applications such as photonic signal processing.