Structural and optical properties of Co-doped ZnS nanoparticles synthesized by a capping agent

Cobalt-doped Zinc sulfide (ZnS) nanoparticles were prepared by a simple chemical method using alkyl hydroxyl ethyl dimethyl ammonium chloride (YH) as capping agent. The structural and optical properties of prepared cobalt-doped ZnS nanoparticles have been characterized. X-ray diffraction patterns and transmission electron microscope images reveal pure cubic ZnS phase with size of about 5–2 nm for all cobalt-doped ZnS nanoparticles. The lattice constant of the samples decreases slightly by the introduction of Co²⁺ The absorption edge of the ZnS:Co²⁺ nanoparticles is blue-shifted as compared with that of bulk ZnS, indicating the quantum confinement effect. The photoluminescence emission band exhibits a blue shift for Co-doped ZnS nanoparticles as compared to the ZnS nanoparticles.     

Inhibition of Aluminum Alloy Corrosion in 0.5 M Nitric Acid Solution by 4-4-Dimethyloxazolidine-2-thione

The corrosion inhibition of Al-Alloy (Al2024) in 0.5 M nitric acid solution at 30 °C was achieved using 4-4-dimethyloxazolidine-2-thione (DMT) as a corrosion inhibitor. The electrochemical performance of the DMT was studied by electrochemical impedance spectroscopy (EIS), potentiodynamic polarization measurements, and scanning electron microscopic study (SEM). The results indicated that DMT acts as an inhibitor for Al2024 in 0.5 M nitric acid. Polarization curves indicated that DMT was a mixed-type inhibitor. Inhibition efficiencies were observed to be increased with an increase in DMT concentration and attains approximately to 93.4% at 2 mM of DMT in 0.5 M nitric acid. The adsorption of DMT model on Al2024 surface obeyed in accordance with Langmuir adsorption isotherm model. The value of the free energy of adsorption ΔG _ads indicated that the adsorption of DMT molecule was a spontaneous process and was typical of physical and chemical adsorption.     

Woven hybrid composites: Tensile and flexural properties of oil palm-woven jute fibres based epoxy composites

In this research, tensile and flexural performance of tri layer oil palm empty fruit bunches (EFB)/woven jute (Jw) fibre reinforced epoxy hybrid composites subjected to layering pattern has been experimentally investigated. Sandwich composites were fabricated by hand lay-up technique in a mould and cured with 105 °C temperatures for 1 h by using hot press. Pure EFB and woven jute composites were also fabricate for comparison purpose. Results showed that tensile and flexural properties of pure EFB composite can be improved by hybridization with woven jute fibre as extreme woven jute fibre mat. It was found that tensile and flexural properties of hybrid composite is higher than that of EFB composite but less than woven jute composite. Statistical analysis of composites done by ANOVA-one way, it showed significant differences between the results obtained. The fracture surface morphology of the tensile samples of the hybrid composites was performed by using scanning electron microscopy.     

Performance analysis of a double-pass photovoltaic/thermal (PV/T) solar collector with CPC and fins

The use of PV/T in combination with concentrating reflectors has a potential to significantly increase power production from a given solar cell area. A prototype double-pass photovoltaic-thermal solar air collector with CPC and fins has been designed and fabricated and its performance over a range of operating conditions was studied. The absorber of the hybrid photovoltaic/thermal (PV/T) collector under investigation consists of an array of solar cells for generating electricity, compound parabolic concentrator (CPC) to increase the radiation intensity falling on the solar cells and fins attached to the back side of the absorber plate to improve heat transfer to the flowing air. Energy balance equations have been developed for the various nodes of the system. Both thermal and electrical performance of the collector are presented and discussed.     

Feasibility of Kelvin probe force microscopy to measure the surface potential decay of polystyrene film due to relative humidity

The feasibility of measuring the surface potential decay of polystyrene (PS) film is investigated at room temperature by using Kelvin probe force microscopy (KPFM). The PS film was charged by an ion injection method utilizing Bruker's atomic force microscope (AFM) Nanoman module with a pulse duration of 1 ms, SCM-PIT electrically conductive probe, and a voltage pulse of −250 mV. The surface potential decayed linearly on a semi-log scale with time, where the time decay constant was quantified for relative humidity (RH) = 5% by KPFM at room temperature. The surface potential decayed due to the interaction of the PS film with the hydronium ions available in the environment. Furthermore, the effect of the material forms (film vs. microspheres) on the time decay constant at RH = 5% was investigated. The time decay constants measured using different methods exhibited excellent correlation with the AFM-KPFM. This also confirmed that the results are independent of the material form (microspheres vs. film form). As a result, the proposed method can be used to measure the effect of RH for any PS surface (i.e., particles of various sizes and films) exposed to these environmental conditions.     

Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma

Simple SummaryMembrane-associated PCNA is expressed on the surface of human MM cell lines and primary MM cells. Mab 14-25-9 interacts with membrane-associated PCNA and blocks its binding to NK-expressed NKp44, thus activating NK function. We showed that mAb 14-25-9 can serve as an immune checkpoint blocker, enhancing the function of NK cells on target human MM cell lines and primary cells.AbstractMultiple Myeloma (MM) is a devastating malignancy that evades immune destruction using multiple mechanisms. The NKp44 receptor interacts with PCNA (Proliferating Cell Nuclear Antigen) and may inhibit NK cells’ functions. Here we studied in vitro the expression and function of PCNA on MM cells. First, we show that PCNA is present on the cell membrane of five out of six MM cell lines, using novel anti-PCNA mAb developed to recognize membrane-associated PCNA. Next, we stained primary bone marrow (BM) mononuclear cells from MM patients and showed significant staining of membrane-associated PCNA in the fraction of CD38⁺CD138⁺ BM cells that contain the MM cells. Importantly, blocking of the membrane PCNA on MM cells enhanced the activity of NK cells, including IFN-γ-secretion and degranulation. Our results highlight the possible blocking of the NKp44-PCNA immune checkpoint by the mAb 14-25-9 antibody to enhance NK cell responses against MM, providing a novel treatment option.     

A basic program for calculating subsurface water temperatures using chemical geothermometers-implication to geothermal reservoir estimation

GEOTHERM is a computer program written in BASIC language to estimate geothermal reservoir temperature using the well-known chemical gèothermometers. The empirical equations used in the program were obtained from the literature. Three different chemical geothermometers are included in the program: Na-K, Na-K-Ca, and silica geothermometers; this gives the user the opportunity not only to select the most reliable geothermometer in estimating subsurface temperature, but also to select the type of geothermometer according to available data. A sample input file of geothermal waters obtained from Iceland has been tested, so as to show the applicability and usefulness of the program.     

Dynamic Analysis of Truss‐Beam System

As the manned exploration of space continues, many complex structural components are being developed to construct the orbital platforms that will be used to house communication hardware, personnel, and manufacturing complexes. These components are extremely flexible and complex in their behavior. There is a need for a simple method for determining the dynamic characteristics of these space structures with a minimum of effort. A mathematical model of one of these structural elements, an articulating truss beam, has been developed to predict its dynamic response. Assumptions of the force interaction between the beam elements and the joints have been made for using this model. Algorithms are provided to determine the flexibility matrix of the truss beam for use in the equation of motion. The natural frequencies obtained from using this method are compared with those obtained by the finite element method. An experimental procedure is planned to validate the results from the theoretical method.     

Immune and Anticancer Responses Elicited by Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccines Modified by a TLR2 or TLR9 Agonist

The mucin MUC1 is overexpressed and aberrantly glycosylated by many epithelial cancer cells manifested by truncated O‐linked saccharides. Although tumor‐associated MUC1 has generated considerable attention because of its potential for the development of a therapeutic cancer vaccine, it has been difficult to design constructs that consistently induce cytotoxic T‐lymphocytes (CTLs) and ADCC‐mediating antibodies specific for the tumor form of MUC1. We have designed, chemically synthesized, and immunologically examined vaccine candidates each composed of a glycopeptide derived from MUC1, a promiscuous T_helper peptide, and a TLR2 (Pam₃CysSK₄) or TLR9 (CpG‐ODN 1826) agonist. It was found that the Pam₃CysSK₄‐containing compound elicits more potent antigenic and cellular immune responses, resulting in a therapeutic effect in a mouse model of mammary cancer. It is thus shown, for the first time, that the nature of an inbuilt adjuvant of a tripartite vaccine can significantly impact the quality of immune responses elicited against a tumor‐associated glycopeptide. The unique adjuvant properties of Pam₃CysSK₄, which can reduce the suppressive function of regulatory T cells and enhance the cytotoxicity of tumor‐specific CTLs, are likely responsible for the superior properties of the vaccine candidate 1 .     

Prothrombotic states associated with retinal venous occlusion in young adults

BACKGROUND: The etiology of retinal venous occlusion in young patients is not well understood although thrombosis does occur histologically. A search for the risk factors that may lead to thrombosis is highly desirable may contribute to our understanding of the pathogenesis of this complication and may improve our therapeutic strategies. METHODS: We studied 17 patients with retinal venous occlusion. All patients were under 45 years of age (mean 37.8 +/- 7.1). Antiphospholipid antibodies (APAs) and certain hemostatic factors were determined. The results obtained in these patients were compared to those of normal controls. RESULTS: We found APAs in 8 out of 17 patients compared to 5 out of 60 controls (p = 0.0002). In patients with major trunk occlusion, there was a trend for the presence of APAs in those with poor visual acuity at presentation. Deficiencies of the coagulation inhibitor proteins C and S and antithrombin III activities were detected in 6 patients, and reduced levels of Factor XII were found in 4 patients. Levels of hematocrit, erythrocyte sedimentation rate. Fibrinogen, alpha 1-globulin, and alpha 2-globulin were significantly higher in patients compared to the controls (p = 0.019; 0.014; 0.0001; 0.011; 0.047), indicating increased blood viscosity in patients with retinal venous occlusion. CONCLUSION: Prothrombotic changes in the form of APAs and/or deficiencies of coagulation inhibitors and Factor XII may contribute to the etiology of retinal venous occlusion in young adults. Young patients with retinal venous occlusion should be evaluated for these prothrombotic states.