Continuous Renal Replacement Therapy (CRRT) Attenuates Myocardial Inflammation and Mitochondrial Injury Induced by Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) in a Healthy Piglet Model

In this study, we investigated the myocardial inflammation and mitochondrial function during venovenous extracorporeal membrane oxygenation (VV ECMO) and further evaluated the effects of continuous renal replacement therapy (CRRT) on them. Eighteen piglets were assigned to the control group, ECMO group, and ECMO+CRRT group. Myocardial inflammation was assessed by the activity of myeloperoxidase (MPO), myocardial concentrations, and mRNA expression of TNF-α, IL-1β, and IL-6; mitochondrial function was assessed by activities of mitochondrial complexes I–V. VV ECMO elicited a general activation of serum and myocardial inflammation and significantly decreased the activities of mitochondrial complexes I and IV. After being combined with CRRT, serum and myocardial concentrations of IL-1β and IL-6, myocardial mRNA expression of IL-6, and the activity of MPO were decreased significantly; the activities of mitochondrial complexes were increased. We conclude that myocardial inflammation was activated during ECMO therapy, inducing mitochondrial injury; moreover, CRRT reduced myocardial inflammation and partially ameliorated mitochondrial function.     

转化糖注射液对于神经外科危重症患者血糖的影响

目的比较神经外科危重症患者输注10%转化糖和10%葡萄糖溶液对于患者血糖水平的影响。方法选择该院40例神经外科危重症患者,在转入重症监护室(ICU)第1天分别给予10%转化糖(实验组)或10%葡萄糖溶液(对照组)1 000mL,间隔4h监测1次血糖值,同时纪录患者给药前后肝肾功能指标,比较两组血糖变化值的差异。结果实验组的血糖波动小于对照组,差异有统计学意义(P<0.05)。两组输液后肝肾功能无明显差异。两组均未出现过敏反应。结论 10%转化糖较10%葡萄糖更适合用于神经外科危重症患者血糖的控制。     

血液透析与腹膜透析在病人生命质量与费用方面的对比研究

随着终末期肾病病人的增加,血液透析和腹膜透析病人也越来越多,因此从透析病人生命质量及经济负担方面进行了比较总结,为病人合理选择治疗方法提供依据.     

Lipid-rich Carcinoma of the Breast: a Case Report

Lipid-rich carcinoma is a rare variant and accounts for < 2% of all breast cancer diagnoses. We report a case occurring in a 53-year-old female. The patient presented with a painless, right breast mass. Clinical examination and mammography suggested malignancy. Subsequent modified radical mastectomy revealed the diagnosis of lipid-rich carcinoma. The morphological features, differential diagnosis and treatment along with a brief review of the literature are discussed in this article.

Lipid-rich carcinoma (L-RC) is a very rare variant of breast carcinomas with an aggressive clinical course and poor prognosis. It presents only 1% to 2% of all breast cases (1,2). It is classified as a specific variety of mammary carcinoma because the tumour cells possess abundant vacuolated cytoplasm which is strongly positive when stained for neutral fat. Aboumrad (2) first described it in 1963 as lipid-secreting carcinoma. However, Ramos and Taylor (1) renamed it as lipid-rich breast carcinoma. In China, the first case was reported in 1984 (3). Herein, we report a case of lipid-rich carcinoma occurring in a 53-year-old female patient, and the literature is reviewed.     

新时代高职院校大学生美好生活认知调查研究

以赣南卫生健康职业学院为例,通过对高职院校大学生对美好生活向往认知现状进行调查分析,为高校思政教育中关于美好生活观的教育提供理论依据。     

Mitochondrial DNA control region sequences may differentiate Yanbian Koreans in China from other Asian populations

Abstract

Background: Sequence polymorphisms of mitochondrial DNA (mtDNA) are valuable in forensic medicine and anthropological genetics.

Aim: This study investigated the mtDNA control region sequences in 295 unrelated individuals living in the Yanbian Korean Autonomous Prefecture in the People’s Republic of China.

Subjects and methods: DNA was extracted from blood stained filter papers. Hypervariable regions of the mtDNA control region (HVI and HVII) were amplified and sequenced. The resulting sequences were aligned and compared with the revised Cambridge reference sequence (rCRS).

Results: A total of 182 variations were confirmed. Population comparison showed the significant difference between Yanbian Korean and other included populations.

Conclusion: These results provide useful data for human genetic studies and forensic examinations and demonstrate that the Yanbian Korean population is an endogamous Northeast Asian group.     

十二指肠结节性病变病理分型及诊断17例

目的:确定十二指肠结节性病变组织病理学特征及分型.方法:统计分析经内镜下被确诊为十二指肠结节性病变患者的资料.对其年龄、性别、类型、症状、最后诊断、相关疾病和组织病理学特点等记录进行回顾性研究.同时亦分析患者血红蛋白、平均细胞体积、血清铁蛋白、白蛋白、免疫球蛋白、腹腔自身抗体、贾第虫和粪便OVA寄生虫,ELISA分析贾第虫的特异性抗原水平.结果:筛选出17例经内镜确诊为十二指肠结节性病变的患者.诊断时平均年龄为28.1岁(17-56岁),男9例,女8例.十二指肠结节性病变中,腹痛(47%)是最常见的临床症状,胃窦结节(41%)是最常见的内镜表现.十二指肠结节性病变的组织病理学评估显示,所有患者均有慢性炎症,嗜酸性粒细胞在隐窝间和上皮内增殖占70.5%,47%的患者存在绒毛萎缩.通过组织学检查和/或特定的蓝氏贾第鞭毛虫粪便抗原阳性实验显示有6例患者感染贾第虫.患者的临床诊断显示某些特征,如腹泻、贾第虫病、分泌型IgA缺乏症和幽门螺杆菌(Helicobacter pylori,H.pylori)胃炎,并且他们中的一些与其他的有相关性.结论:十二指肠结节性病变其黏膜有明显淋巴细胞和/或嗜酸性粒细胞浸润,建议应对造成这一显著炎症反应的微生物学和免疫学病因进行进一步研究.     

Xpert MTB/RIF试验快速诊断结核病的研究进展

<正>结核病是由结核分枝杆菌(Mycobacterium tuberculosis,MTB)感染引起的慢性传染病,仍然是全世界公共卫生面临的重大威胁。据世界卫生组织统计~([1-2]),我国2014年的新发肺结核人数位居全球第三位,是22个全球结核病高负担国家之一。目前肺结核的诊断主要依靠痰涂片抗酸染色,但由于痰涂片对标本的含菌量要求高,导致其诊断结核病的敏感度较低。诊断结核病的金标准是MTB培