法莫替丁与H1受体拮抗剂联合治疗慢性荨麻疹124例疗效观察

124例单用H1受体拮抗剂治疗疗效差的慢性荨麻疹患，联合应用法莫替丁治疗4周，结果显示临床痊愈率和显效分别为85．4％和10．5％，表明法莫替丁与H1受体拮抗剂联合用于这类H1受体拮抗剂不能奏效的慢性荨麻疹患是一种有效的治疗方法。     

Differentiation of human epidermal stem cells into fibroblasts induced by TGF-β1 in vitro

Objective To investigate the correlation between human epidermal stem cell (hESCs) and hypertrophic scar or keloid. Methods Improved collagen Ⅳ-coated adhesion methods was used to isolate and culture the epidermal stem cells after neutral protease selectively digested the dermo-epidermal junctions. After the cells were cultured and expanded in vitro, and passage 3 hESCs were induced by different concentrations of TGF-β1 (0.1, 5.0, and 10.0 ng/ml). Morphological fea-tures and identification of these cells were meseasured by HE, Masson, immunohistochemical staining on the days 3 and 7, respectively. Results After induced by TGF-β1 for 3 and 7 days, the morpholo-gy of the epidermal stem cell (hESCs) was changed into fusiform shape, similar to fibroblasts. 70 % ofthe cell which was induced by TGF-β1 were blue stained in the cytoplasm by Masson stain, which is the distinctive method for collagen, suggesting collagen appeared or increased in the cells. The collagen concentrations in supernatants of hESCs were 0.4150±0.0014, 0.3380±0. 0020, and 0.3870±0.0020, much higher than that in control group (0.0780±0.0025) and normal skin fibro-blast group (0.15004±0.0051) (P<0.05). Immunohistochemical staining revealed that positive rates of these cells for anti-vimentin staining were more than (95.00±1.20)% in experiments and (5.70±0.20)% in control group. Conclusion The differentiantion of hESCs induced by TGF-β1 into fibro-blasts indicates that hESCs may play a role in the pathogenesis of hypetrophic scar and keloid.     

口腔颌面部鳞癌术前平阳霉素化疗的疗效分析

我国独创的抗癌抗菌素──平阳霉素问世10多年来,通过大量的临床实践,业已证明对头颈部鳞癌有显著疗效。作者自1979年6月～1991年6月采用单一平阳霉素术前给药加根治性手术切除共治疗口腔颌面部鳞癌100例,总结分析如下:资料和方法1.病例本组病例未加特殊选择,100例中男性66例;女性34例。年龄20～76岁;中位年龄47岁。初发病例72例;复发病例28例,均已经过手术或放疗治疗。发病部位:唇16例、舌23例、牙龈15例、颊粘膜25例、口底6例、软腭4例、口咽6例、硬腭5例。初     

以高钙性肾病为突出表现的原发性甲状旁腺功能亢进1例

以高钙性肾病为突出表现的原发性甲状旁腺功能亢进１例大连医科大学附属第二医院肾内科（１１６０２３）尹永红麻军患者男，４２岁。以多饮、多尿２年，恶心、呕吐３个月为主诉入院。２年前出现烦渴、多饮，每日饮水量７５００～１００００ｍｌ，多尿、夜尿增多。未介意。...     

老年冠心病患者血清维生素C水平及脂质,脂质过氧化关系的研究

老年冠心病患者血清维生素Ｃ水平及脂质、脂质过氧化关系的研究张景云路方红阮景纯吴坚美张善同（山东省医学科学院心血管病研究室，济南２５００６２）氧自由基及脂质过氧化反应与冠状动脉疾病（ＣＡＤ）的发生和发展密切相关〔１，２〕。维生素Ｃ（ＶＣ）作为体内主要的...     

人表皮生长因子在大肠杆菌中的融合表达与活性分析

人表皮生长因子在大肠杆菌中的融合表达与活性分析赵忠良路凡陈南春柴玉波陈苏民（第四军医大学生物化学与分子生物学教研室西安７１００３３）关键词人表皮生长因子基因表达融合蛋白大肠杆菌中图号Ｑ７７４表皮生长因子为一小分子多肽生长因子，能促进多种上皮细胞的分化...     

松节油合成的杀虫增效剂

杀虫增效剂是指对昆虫没有或者很少有杀虫效果的一类化学品,但当它与某些杀虫剂混合使用,能提高杀虫剂的药效,从而达到减少杀虫剂用量,降低成本,减少环境污染的目的。同时,随着长时间的用药,许多害虫对一些杀虫剂均有不同程度的抗性,加入增效剂也是减少抗性的手段之一。 松节油是松脂加工后得到的萜烯类物质,     

东莨菪碱与复方丹参针治疗高血压病92例疗效观察

我院从1991年元月～1993年12月用复方丹参与东莨菪碱治疗高血压病92例,效果满意,汇集如下:     

犬环杓后肌电起搏参数

双侧喉返神经(RLN)损伤可致气道梗阻,选择性切除喉内组织或声带外移恢复呼吸功能的几种手术均不太理想。有报道对喉返神经麻痹采用电刺激喉内肌改善喉功能,但电起搏的许多参数尚不清楚,作者介绍一组试验并确定一组参数。将杂种成年犬分成两组,Ⅰ组RLN紧急切断术(对照组),Ⅱ组RLN切断加静脉注射巴夫龙(0.1mg/kg),旨在消除对神经的直接刺激。分离暴露环杓后肌(PCA),将两个特制的针电极间距2mm平行插入PCA,垂直于肌纤维,电极间所产生的椭圆形电场与肌纤维