微小胃癌及小胃癌的诊断——附18例回顾性分析

本文分析了24年中发现的6例微小胃癌和12例小胃癌的临床和病理特点。认为某些微小胃癌患者临床症状不明显,应适当放宽胃镜检查指征,特别对胃癌高危人群;对可疑病灶,内窥镜活检取材必须取准、取深,并作多块活检。病理活检胃粘膜重度异型增生两次以上可考虑手术治疗。     

MORPHOMETRIC STUDY OF GASTRIC PRECANCEROUS LESIONS: Ⅱ. QUANTITATIVE ANALYSIS OF NUCLEUS-GLAND RATIO

One handred thrity-one foci of gastric mucosa with intestinal type of lesions (including simple intestinal metaplasia 27;intestinal type dysplasia in different grades: mild 30, moderate 35, sever 20; intestinal type of gastric carcinoma 19) have been submitted to morphometric analysis using automatic image analysis system (Quantimet 900). The ratio of the area of nucleus to the area of cells per gland was measured by image analysis, and was referred as index of nucleus-gland ratio (ING) which represented the size and quantity of nuclei as well as the degree of their pseudostratification. The mean values and standard deviations of ING measured in each group were as follows: (1) simple intestinal metaplasia (as control group): 0.165-4-0.025; (2) mild dysplasia: 0.21±0.023; (3) moderate dysplasia: 0.259±0.026; (4) severe dysplasia: 0.32±0.028; (4) differentiated carcinoma: 0.371±0.052. In addition, the ING values showed a normal distribution in each group and statistically significant difference among them by t-test (P<0.01). Thus, ING is a useful parameter for the diagnosis of gastric precancerous lesions.     

MORPHOMETRIC STUDY OF GASTRIC PRECANCEROUS LESIONS: I. QUANTITATIVE DIAGNOSIS OF CELL ATYPISM IN GASTRIC BIOPSY SPECIMENS

The cell atypism is one of the important criteria for making diagnosis of precancerous lesions of gastric mucosa, in routine pathological examination, it is evaluated by the degree of atypism of cell nucleus. 5 461 cells in 50 foci of gastric mucosa with intestinal type of lesions (including simple intestinal metaplasia 10; intestinal type dysplasia in different grades: mild 10. moderate 11, severe 9; intestinal type gastric carcinoma 10) have been submitted to morphometric analysis by automatic image analysis system (Quantimet 900). 7 geometric parameters of nucleus were measured by analysis, including: (1) Area; (2) Perimeter; (3) Diameter (2. Area/π1/2; (4) Length; (5) Breadth; (6) Axis ratio (Length / Breadth); (7) Contour (Perimeter~2 / 4π·Area), these parameters represent the size and shape of nucleus. The results of measurements indicated that value of the above mentioned parameters, except the axis ratio and the contour of cell nucleus, all increased in accord with the increase of severity of the atypism in various intestinal type lesions, hence they can be used as objective criteria for quantitative evaluation of gastric precancerous lesions.     

48例下段回肠病变的内镜与病理组织学观察

下段回肠是小肠疾病的好发部位,也是大肠疾病容易波及的部位。该处病变的X线造影检出率较低,有时即使剖腹探查,也常常因未取到病理组织而难于确诊。因而长期以来,下段回肠疾病的发病机理、组织学改变及治疗方面均未深入研究。晚近,纤维小肠镜问世为小肠疾病的研究创造了条件,直视取材提高了小肠疾病的诊断率。但是,采     

胃粘膜细胞动力学研究进展

胃粘膜细胞动力学是研究胃上皮细胞群体周期性动态变化规律的科学。胃癌及其癌前病变的细胞动力学研究,有助于阐明胃癌前病变的生物学特征和转化规律,对于探讨胃癌的组织发生学和开展计划防治工作均有实际意义。     

胃浆细胞肉芽肿一例报告

胃浆细胞肉芽肿(Gastric plasma cell granuloma,GPCG)是一种极为罕见的瘤样病损,迄今世界文献中仅见3例报导。我们最近发现一例,经组织化学及电镜证     

普通变异型免疫缺陷病

普通变异型免疫缺陷病(Common va-riable immunodeficiency,CVID)是一组比较笼统的疾病范畴,根据WHO专家会议的推荐,将凡不能列入已确定的原发性免疫缺陷病(PID)的其它类型均归于本病。“普通”是指本病为常见的PID类型,具有较高的发病率。“变异”的含义很广,包括发病年龄的不定,病因发病机理的多样以及临床表现的易变。由于缺乏相应的动物模型,因而在较长的时间内对本病的本质一直认识不清。晚近,由于对淋巴细胞亚群研究的不断深入,尤其是应用单克隆技术和淋巴细胞酶生化代谢研究的开展,对本病的认识才日趋完善,现认为CVID的发病除了与原发性B细胞缺陷有关外,还与T细胞调控网络的异常密切有关,并且分出了以B细胞缺陷为主和以T细胞缺陷为主的两类基本的CVID表