THE RELATIONSHIP BETWEEN THE LEVEL OF LIPIDEMIA AND THE MACROVASCULAR COMPLICATIONS OF DIABETES

363 diabeitics in Beijing and Tianjin and 602 non-diabetics served as control were tested for the serum lipids and lipoproteins, including to- tal serum cholesterol, triglyceride, HDL-chole- sterol (HDL-C), rat.io of HDLrC to LDL-.Cihole- sterol (LDL-C). The occurrence rate of hyperlipoproteina.e- mia in the diabetic gro'up (21.7To) was s.ignificant-- ly higher than that in the control group (8.3To, p相似文献   

血浆葡萄糖,胰岛素比值是可靠的胰岛素敏感性指数吗？

本文５０８例资料显示，国内、外文献中常用的空腹血糖（ＦＰＧ）与胰岛素（ＦＩＮＳ）比值——Ｇ／Ｉ不能对非糖尿病人群的胰岛素敏感性（ＩＳ）做出正确评估：（１）在ＩＳ逐渐降低表现为ＦＰＧ及ＦＩＮＳ水平都依次递增的各组中，Ｇ／Ｉ判定的ＩＳ在相应各组间差异无显著性；（２）在ＩＳ降低表现为ＦＩＮＳ水平相似而ＦＰＧ较高的各组中，Ｇ／Ｉ值对ＩＳ做出与实际完全相反的判断。表明在ＩＳ降低表现为ＦＰＧ、ＦＩＮＳ同步升高者，Ｇ／Ｉ完全丧失正确判定ＩＳ的能力。在ＩＳ降低仅表现为血糖水平升高而β细胞不能代偿性增加ＦＩＮＳ者，Ｇ／Ｉ也不是评价ＩＳ的可靠指数。     

CLONING OF APOPROTEIN AI GENE AND OBSERVATIN ON DNA POLYMORPHISM OF APOPROTEIN AI/CII GENE-LOCIIN GENOMIC LIBRARY FROM A LIVER OF CHINESE

For the research on the structure and function of the HDL apoproteins, we have successfully constructed a complete genomic library, in self-prepared EMBL3 lambda vector and the packaging extracts of lysogenic strains BHB2688, BHB2690, from a Chinese fetal liver, which will be widely used in the research on the structure and function of apoproteins. In this study, a DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst1 and hybridization with an apoprotein AI cDNA probe, has been shown to be located at apoAI/CIII gene-loci. Three gene related fragments (5.7 Kb, 4.0 Kb and 3.0 Kb) were detected. The 5.7 Kb fragment is common and the polymorphism is demonstrated by the presence of either a 4.0 Kb fragment (S1 allele) or the 3.0 Kb fragment (S2 allele). Individuals were genotyped S1S1 or S1S2. Our result showed that the frequency of genotype S1S2 was higher in hypertriglyceridemic subjects than that in normolipidemic subjects.     

直流气体放电活化反应蒸发沉积SnO_x超微粒子薄膜

制得的SnO_x薄膜,用扫描电子显微镜和X射线衍射仪分析,显示为平均颗粒小于50nm的超微粒子薄膜。其中组成颗粒的晶粒大小平均为5.0～8.0nm。讨论了沉膜过程中基底温度、氧气分压、放电电压、蒸发源温度和反应蒸镀时间对薄膜结构和性质的影响。得到了制备SnO_2相含量较高,且接近无色透明的超微粒子薄膜的最佳工艺条件。     

在中国和美国非胰岛素依赖型糖尿病人和对照组中血浆脂蛋白和载脂蛋白的比较

中国10名女性和8名男性对照组载脂蛋白A-Ⅰ(APOA-Ⅰ)水平(平均值分别为146、158mg％)高于美国15名女性和33名男性对照组(分别为130、124mg％,P=0.01)。中国男性糖尿病13人APO A-Ⅰ(147mg％)高于美国男性糖尿病13人(104mg％,P<0.01)和男性对照组(P=0.01)。中国女性糖尿病10人APO A-Ⅰ(142mg％)高于美国女性对照组(130mg％,P=0.02),也较美国女性糖尿病者(136mg％)为高。     

糖尿病鼠胰岛素治疗后血压升高机制及探讨

雄性Ｗｉｓｔａｒ大鼠以含０．３％氯化钠饲料喂养，用ＳＴＺ６５ｍｇ／ｋｇ制成ＤＭ模型，予胰岛素８～１２Ｕ／ｄ治疗，使血糖控制在正常水平，这时糖尿病组血浆胰岛素水平（３８．６±２．４Ｕ／Ｌ）明显高于对照组（１５．４±１．８Ｕ／ｕ），表明ＤＭ鼠模型已产生医源性高胰岛素血症，测血压、心率、血去甲肾上腺素、２４小时尿ＶＭＡ（三甲基四羟基苦杏仁酸）均明显高于对照组（２１．３±２．７ｋＰａ，４４５±１５次／分，０．５２±０．０３ｎｍｏｌ／２４ｈ，１．４７±０．０３μｍｏｌ／２４ｈ对１４．１±２．０ｋＰａ，３６０±１５次／分，０．３１±０．０２ｎｍｏｌ／２４ｈ，０．５４±０．０４μｍｏｌ／２４ｈ），但２４小时尿钠（０．５０±０．０８ｍｍｏｌ，ｋｇ－１／２４ｈ）明显低于对照组（１．２０±０．１２ｍｍｏｌ·ｋｇ－２／２４ｈ），二组间血醛固酮无差异，表明高胰岛素能引起血压升高，可能与体内钠潴留和交感神经活性增强有关，而与醛固酮关系不明显。     

糖耐量异常患者ApoE表型与高脂血症关系

本文对92例糖尿病病人,174例糖耐量低减病人及124例糖耐量正常人的ApoE表型与高脂血症关系的研究表明,糖耐量异常患者ApoE表型异常主要表现为E_(3/3)明显减少、E_(2/3)显著升高。高脂血症主要与血糖的升高呈正相关,但反映遗传基因不同的ApoE表型也与高脂血症有关。     

糠尿病系列知识之五——糖尿病的胰岛素治療

什么情况要用胰岛素 胰岛素依赖型糖尿病人如果不用胰岛素,就有发生酮症酸中毒的危险,甚至危及生命。非胰岛素依赖型糖尿病人如有下列情况,需用胰岛素治疗。①合理的饮食及口服降糖药治疗仍不能很好地控制血糖、尿糖者,血浆胰岛素水平确实较低者,不用胰岛素有时出现酮症酸中毒者;②糖尿病伴有肝病、肾病者以及发生感染或手术后;③妊娠期糖尿病患者:④严重胰腺疾病所致的糖尿病;⑤最初表现为非胰岛素依赖型糖尿病,而实质上是胰岛素依赖型糖