窝沟封闭剂用于正畸儿童的临床观察

窝沟封闭剂用于正畸儿童的临床观察朱红马炳岿杜辉目前我国儿童的龋齿发病率仍然很高，据调查６～１２岁儿童龋齿发病率达４０～５０％，其中面窝沟龋占８０％以上．在我科接受正畸治疗的患儿中，有一半以上的孩子治疗前已出现不同程度的第一恒磨牙龋．由于戴入矫正器后...     

心外科术后患者手法辅助排痰临床护理

我们对比观察100例心外科术后患者应用手法辅助排痰技术,结果显示该技术在咳痰效果、咳痰疼痛、肺不张、胸水、低氧血症、呼吸机辅助时间上有显著性差异。现报告如下。1临床资料50例心外科手术后患者应用手法辅助护理(辅助组),男35例,女15例,2~75岁,体重10~90kg,心功能Ⅱ~Ⅳ级,其中冠状动脉搭桥术18例,瓣膜置换术23例,房室缺修补术9例,术前合并房颤8例、高血压11例,体外循环38例,非体外循环12例。另50例同类手术患者,术后应用传统的雾化吸入叩背咳痰技术(对照组)。2方法2·1上胸廓辅助治疗者的手掌,紧贴在患者两侧锁骨下前胸部,随呼气压胸廓…     

主班工作制在泌尿科临床工作中的应用

2006年10月开始上主班，通过近2个月的主班工作及与前两任主班的共同经验交流，探讨泌尿科主班工作制在临床工作中的应用，现介绍如下。     

营养性贫血的胃粘膜变化特点及其相关性

营养性贫血的胃粘膜变化特点及其相关性朱红朱玉群首都医科大学附属北京天坛医院内科北京市１０００５０Ｓｕｂｊｅｃｔｈｅａｄｉｎｇｓａｎｅｍｉａ，ｉｒｏｎｄｅｆｉｃｉｅｎｃｙ／ｃｏｍｐｌｉｃａｔｉｏｎｓ；ｇａｓｔｒｉｔｉｓ／ｅｔｉｏｌｏｇｙ；ｇａｓｔ...     

北京发现由CoxA_(16)病毒引致的一次手足口病

本文报告了1983年10月在北京一幼儿园中由CoxA_(16)肠道病毒引起的手足口病。共发病62例,发病率达32.1%。临床表现为手、足部典型的丘疹、疱疹,口腔粘膜疹和溃疡,平均病程6.46天,预后良好。从17例病人粪便中分离出7株病毒,阳性率41.2%,均为CoxA_(16)肠道病毒。5例病人双份血清有4例中和抗体效价呈4倍增长。     

彩超及CT对10例肾上腺髓样脂肪瘤的诊断对比

肾上腺肿瘤的检查方法很多，CT对于肾上腺肿瘤可获得90％以上的诊断正确率。实时超声显象诊断肾上腺肿瘤，其准确率可达84．2％，应用实时超声诊断肾上腺疾病及其对肾上腺肿瘤的定位诊断具有重要的临床意义。而对于肾上腺髓样脂肪瘤，其CT与超声诊断准确率与上述标准并不完全符合。现将我们经过超声与CT检查，并经过手术病理确诊的10例肾上腺髓样脂肪瘤报告如下。l资料与方法10例患者中，男6例，女士例，平均年龄51岁（范围犯～门岁）。4例为上腹部胀痛，基层B超发现右侧肝脏占位，我们B超诊断为右肾上腺占位，经CT证实，收入普外科手术…     

Effect of ipratropium bromide on airway and pulmonary muscarinic receptors in a rat model of chronic obstructive pulmonary disease

Objective　To observe the level of muscarinic receptors in airway and lung tissues, and the effect of inhaled ipratropium bromide on these receptors in a rat model of chronic obstructive pulmonary disease (COPD). Methods　This model was developed by exposure of rats to 250 ppm SO2 gas, 5?h/d, 5d/wk, for a period of 7 wk. The COPD rats inhaled 0.025% aerosolized iratropium bromide for 20 min, 2 times daily, in an airtight chamber. Muscarinic receptors in airway and lung tissues of normal rats, ipratropium bromide-treated COPD rats and the recovering COPD rats were measured by the radio-ligand binding assay. Results　Airway/lung pathology and pulmonary function tests showed that chronic SO2 exposure caused pathophysiologic changes similar to those observed in human COPD. The density (0.038±0.011, pmol/mg protein) and affinity (Kd, 23±11 pmol/L) of muscarinic receptors in airway and lung tissues of COPD rats were not changed compared with those of normal control rats (0.030±0.008 and 29±19, respectively, P>0.05). Densities of the muscarinic receptors were not changed after inhalation of ipratropium bromide for 5 days, but increased significantly after inhalation for 30 days, as compared with those of the untreated COPD rats. The muscarinic receptors returned the normal levels at day 6 after cessation of ipratropium bromide treatment. There were no differences among different groups of rats in equilibrium dissociation constants (Kd). Conclusion　A rat model of COPD with pathophysiologic changes similar to the human counterpart was developed using chronic SO2 exposure. There was no significant change in the number and function of muscarinic receptors in airway and lung tissues of the COPD rats, but upregulation of the muscarinic receptors was observed after long-term inhalation of ipratropium bromide.     

呼吸机相关性肺炎240例分析

呼吸机相关性肺炎 (Ｖｅｎｔｉｌａｔｏｒ＿ａｓｓｏｃｉａｔｅｄｐｎｅｕｍｏｎｉａ,ＶＡＰ）是一种病人接受机械通气之后所出现的医院获得性肺炎 ,是使危重病人并发症及死亡率增加的重要原因之一 ,诸多因素可以导致ＶＡＰ发生。如何预防和治疗ＶＡＰ ,是目前临床上治疗危重病人时所面临的一个重要课题。我科在１９９３年４月～１９９８年１２月共发生ＶＡＰ２４０例 (接受机械通气患者８５０例 ) ,现报道分析如下。１．一般资料 :２４０例中男性１６４例 ,女性７６例。年龄２７～８９岁 ,平均５６±１１岁。接受机械通气时间１１～７３天…     

妊娠合并尖锐湿疣40例临床分析

尖锐湿疣 (Coclyloma,acuminatum,CA)又称尖圭湿疣 ,生殖器疣 ,由人乳头瘤病毒 (HPV)感染所致 ,是最常见的性传播疾病之一。本院自 1996年以来用激光加用克疣王外涂创面治疗妊娠合并生殖道感染尖锐湿疣 ,取得较满意效果 ,现报告如下。1　临床资料1)　一般情况 :本组 40例 ,已婚 32例 ,未婚 8例 ,年龄最小 18岁 ,最大 36岁 ,平均年龄 2 4.5岁。年龄最小 5周 ,最大 2 4周 ,平均 12 .3周。卖淫传染 9例 ,被丈夫及男友传染 2 6例 ,原因不明 5例。2 )　临床表现 :白带增多 ,外阴瘙痒 16例 ;自觉外阴出现新生物 6例 ;无自觉症状 ,因男友有类似…     

Retrospective Study on the Efficacy and Safety of Quinacrine Sterilization

Objective To observe and evaluate the efficacy and safety of quinacrine sterilization.Methods A total of 572 cases of quinacrine sterilization preformed during the 4 years from 1993to 1997in Jiangsu and Guizhou Provinces were employed in this study. The efficacy and safety of quinacrine sterilization in those case were studied and evaluated, with 588 cases of surgical sterilization performed at the same time being the control group.Results Both groups were with identical demographic and gynecological characteristics. The result of multiple decrement life table analysis showed the 12th gross cumulative failure rates for quinacrine sterilization was 3. 13% and serious side effects occurred in only 2 cases accounting for O. 35%. One was ectopic pregnancy (20 months after treatment). The other was due to anaphylaxis in 10 minutes after the second insertion). No difference in the liver and nephic functions was detected and no suspected cancer cells or cancer cells were found in the two groups. 99. 6% of the 572 women interviewed accepted the quinacrine sterilization.Conclusions Quinacrine sterilization method is with high acceptability but comparatively low effectiveness. It has been proved to be a safe method of contraception in short-term. However, the safety of long-term still needs further study.