低温与振动联合作用对周围循环功能及神经功能的影响

Objective To study the combined effect of low temperature and vibration on function of peripheral circulation and nerve.Methods 64 rabbits were divided into control group,low temperature group,vibration group and combined effect group randomly,16 each group.The changes of concentration of ET,Ang Ⅱ,NO in plasma and SCV,amplitude of sensory nerve action potential,latency of sensory nerve action potential,MCV,distal amplitude of motor nerve,and distal latency of motor nerve were measured before and after experiment.Results After experiment,the concentration of ET,Ang Ⅱ,NO and SCV,amplitude of sensory nerve action potential,latency of sensory nerve action potential,MCV,distal amplitude of motor nerve,and distal latency of motor nerve were (68.84±14.81) pg/ml,(544.01±70.20) pg/ml,(123.73±9.58) nmol/ml,(25.36±6.96) m/s,(1.84±0.65) μV,(4.05±1.04) m/s,(27.40±6.05) m/s,(1.60±0.52) μV,(3.51±1.30) m/s respectively in low temperature group;(70.22±15.02) pg/ml,(540.77±68.25) pg/ml,(129.46±11.99) nmol/ml,(27.69±6.16) m/s,(2.19±0.53)μV,(3.86±0.89) m/s,(30.03±5.21) m/s,(1.65±0.49)μV,(3.36±1.11)m/s respectively in vibration group;(88.47±13.20) pg/ml,(687.38±101.44) pg/ml,(70.66±4.99) nmol/ml,(20.82±3.65)m/s,(1.21±0.64)μV,(5.05±0.94) m/s,(19.97±4.37) m/s,(1.09±0.49)μV,(4.49±1.26) m/s respectively in eombined effect group;compared with pre-experiment,the concentration of ET and Ang Ⅱ in low temperature group,vibration group and combined effect group were increased after experiment,and the NO was decreased (P＜0.05);the nerve conduct velocity and amplitude was decreased and the latency was delayed (P＜0.05).After experiment,the concentrations of ET and Ang Ⅱ in combined effect group were higher than low temperature group and vibration group,and the concentration of NO in combined effect group was lower than low temperature group and vibration group(P＜0.05).After experiment,the SCV and MCV in combined effect group were slower than low temperature group and vibration group;the amplitude of sensory nerve action potential and distal amplitude of moor nerve were less than low temperature group and vibration group;the latency of sensory nerve action potential and distal latency of motor nerve in combined effect group was longer than low temperature group and vibration group.The factorial analysis results indicated the synergistic effect between low temperature and vibration(P＜0.05).Conclusion Vibration-induced peripheral vascular impairment and nerve impairment would be intensified by low temperature.     

卡托普利对接振家兔神经功能的影响

目的探讨卡托普利对接振家兔神经功能的影响及意义。方法将家兔分为接振组、干预组和对照组,对接振组和干预组进行接振试验,干预组从接振第11天起给予卡托普利。于接振试验前后对各组家兔进行体感诱发电位(SEP)及坐骨神经运动传导功能(MCF)的测定。结果接振组N1波、P1波、N2波的潜伏期分别为(30.76±4.26)、(41.91±6.67)、(45.29±5.81)ms,干预组分别为(27.00±3.04)、(35.07±4.20)、(41.15±3.19)ms。与接振试验前及试验后干预组、对照组比较,接振组SEP各波潜伏时明显延长,差异有统计学意义(P<0.05,P<0.01)。接振组坐骨神经运动传导速度、远端波幅、远端潜伏时分别为(35.69±4.37)ms、(1.55±0.73)μV、(8.16±0.71)ms,干预组分别为(52.20±5.13)ms、(2.89±0.36)μV、(7.26±0.77)ms。干预组较接振组坐骨神经运动传导速度、远端波幅明显延长,远端潜伏时均明显减小,差异均有统计学意义(P<0.01)。结论卡托普利对接振家兔神经功能的损伤有一定的改善作用。     

低温与振动联合作用对周围循环功能及神经功能的影响

Objective To study the combined effect of low temperature and vibration on function of peripheral circulation and nerve.Methods 64 rabbits were divided into control group,low temperature group,vibration group and combined effect group randomly,16 each group.The changes of concentration of ET,Ang Ⅱ,NO in plasma and SCV,amplitude of sensory nerve action potential,latency of sensory nerve action potential,MCV,distal amplitude of motor nerve,and distal latency of motor nerve were measured before and after experiment.Results After experiment,the concentration of ET,Ang Ⅱ,NO and SCV,amplitude of sensory nerve action potential,latency of sensory nerve action potential,MCV,distal amplitude of motor nerve,and distal latency of motor nerve were (68.84±14.81) pg/ml,(544.01±70.20) pg/ml,(123.73±9.58) nmol/ml,(25.36±6.96) m/s,(1.84±0.65) μV,(4.05±1.04) m/s,(27.40±6.05) m/s,(1.60±0.52) μV,(3.51±1.30) m/s respectively in low temperature group;(70.22±15.02) pg/ml,(540.77±68.25) pg/ml,(129.46±11.99) nmol/ml,(27.69±6.16) m/s,(2.19±0.53)μV,(3.86±0.89) m/s,(30.03±5.21) m/s,(1.65±0.49)μV,(3.36±1.11)m/s respectively in vibration group;(88.47±13.20) pg/ml,(687.38±101.44) pg/ml,(70.66±4.99) nmol/ml,(20.82±3.65)m/s,(1.21±0.64)μV,(5.05±0.94) m/s,(19.97±4.37) m/s,(1.09±0.49)μV,(4.49±1.26) m/s respectively in eombined effect group;compared with pre-experiment,the concentration of ET and Ang Ⅱ in low temperature group,vibration group and combined effect group were increased after experiment,and the NO was decreased (P＜0.05);the nerve conduct velocity and amplitude was decreased and the latency was delayed (P＜0.05).After experiment,the concentrations of ET and Ang Ⅱ in combined effect group were higher than low temperature group and vibration group,and the concentration of NO in combined effect group was lower than low temperature group and vibration group(P＜0.05).After experiment,the SCV and MCV in combined effect group were slower than low temperature group and vibration group;the amplitude of sensory nerve action potential and distal amplitude of moor nerve were less than low temperature group and vibration group;the latency of sensory nerve action potential and distal latency of motor nerve in combined effect group was longer than low temperature group and vibration group.The factorial analysis results indicated the synergistic effect between low temperature and vibration(P＜0.05).Conclusion Vibration-induced peripheral vascular impairment and nerve impairment would be intensified by low temperature.     

局部振动对家兔血清肿瘤坏死因子浓度的影响

目的　探讨局部振动对肿瘤坏死因子 (tumornecrosisfactor,TNF)的影响及其意义。方法　将家兔随机分为A组 (接振强度 3.0 3m s2 ,每天接振 0 .5h)、B组 (接振强度 6 .13m s2 ,每天接振 1h)、C组 (接振强度 12 .2 5m s2 ,每天接振 1h)和 1个对照组 (D组 )。各接振组均进行 30d接振试验。分别于试验前、试验第 10、2 0、30天对各组家兔进行血清TNF浓度的测定及分析。结果　在试验前及试验第 10、2 0、30天 ,A组TNF浓度分别为 (3.10± 0 .39)、(3.2 7± 0 .5 8)、(3.79± 0 .5 1)、(4 .16±0 .31) μg L ,B组分别为 (3.16± 0 .4 9)、(3.5 7± 0 .4 3)、(4 .14± 0 .6 9)、(4 .4 8± 0 .4 7) μg L ,C组分别为(3.2 1± 0 .37)、(3.91± 0 .5 0 )、(4 .4 6± 0 .5 9)、(4 .88± 0 .5 4 ) μg L ,D组分别为 (3.2 4± 0 .5 8)、(3.36±0 .6 9)、(3.33± 0 .6 1)、(3.19± 0 .39) μg L。与试验前和实验相同时间对照组比较 ,接振组家兔血清TNF浓度呈增高趋势 ,且差异均有显著性 (P <0 .0 5 ,P <0 .0 1)。结论　局部振动所导致血清中TNF浓度的变化可能与振动病的发病机制有一定关系。     

低温对机体损伤作用的研究进展

工作场所中的低温因素,是常见的职业性物理因素.长期从事低温作业不仅引起机体局部的损伤如冻结、冻伤;而且还对机体神经系统、循环系统、免疫系统、以及骨关节等产生危害,并可引起相应的职业相关性疾患,甚至威胁从业工人的生命.本文结合近年来国内外有关低温对机体损伤的研究资料,对这一领域中的研究进展进行简要综述,旨在为低温对健康影响的防治研究提供一定参考.     

后肢接振对家兔脑组织血管内皮活性物质及ATP酶活力的影响

目的探讨振动对脑组织血管内皮活性物质及ATP酶活力的影响,及其与振动性神经损伤的关系。方法将24只新西兰家兔随机分为低接振强度、中接振强度、高接振强度和对照组,测定各组脑组织中血管内皮活性物质及ATP酶活力。结果随接振剂量的增大,舒张血管物质一氧化氮(NO)、一氧化氮合酶(NOS)有降低趋势,缩血管物质内皮素(ET)有升高趋势,Na -K -ATP酶和Ca2 - Mg2 -ATP酶活力有降低趋势;高强度、中强度组各指标与对照组的差异均有统计学意义(P<0．05,P< 0．01)。结论局部振动可使脑组织血管内皮活性物质及ATP酶活力发生改变,此变化与振动性神经损伤有一定关系。     

混配杀虫剂对小鼠学习记忆功能及大脑组织ATP酶活力的影响

[目的]研究混配杀虫剂对小鼠学习记忆功能的影响,初步探讨染毒后大脑组织ATP酶活力对小鼠学习记忆功能发生改变的作用。[方法]将小鼠随机分为混配杀虫剂染毒A组(丙溴磷与氰戊菊脂混配染毒组)、混配杀虫剂染毒B组(丙澳磷与灭多威混配染毒组)和1个对照组,每组10只。A、B组分别给予高、中、低3种染毒剂量,染毒前及染毒24h后进行跳台试验;应用化学比色法测定各组小鼠大脑组织中Na -K ATP酶、Ca2 -Mg2 -ATP酶的活力。[结果]①与对照组比较,A、B组的高剂量组跳台试验受电击次数分别为(2．90±1．45)次、(3．60±1．96)次,明显增多(P <0．05,P<0．01);总电击时间分别为(86．90±31．12)s、(101．30±38．74)s,明显增加(P<0．05,P<0．01);首次错误潜伏期分别为(74．20±27．88)s、(76．40±35．28)s,明显缩短(P<0．01)。②与对照组比较,A、B组的高剂量组大脑组织中Na -K -ATP酶活力分别为(5．50±2．17)、(5．50±2．97)μmol Pi／(mg prot·h),Ca2 -Mg2 -ATP酶的活力分别为(98．10±19．59)、(81．65±13．12)μmol Pi／(mg prot·h),明显降低(P<0．05,P<0．01)。③跳台试验各指标的改变及大脑组织ATP酶活力的降低,均以高剂量组更明显。[结论]混配杀虫剂能降低小鼠学习记忆功能,这种改变可能与大脑组织中Na -K - ATP酶、Ca2 -Mg2 -ATP酶的活力下降有关。     

低温与振动联合作用对周围循环功能及神经功能的影响

Objective To study the combined effect of low temperature and vibration on function of peripheral circulation and nerve.Methods 64 rabbits were divided into control group,low temperature group,vibration group and combined effect group randomly,16 each group.The changes of concentration of ET,Ang Ⅱ,NO in plasma and SCV,amplitude of sensory nerve action potential,latency of sensory nerve action potential,MCV,distal amplitude of motor nerve,and distal latency of motor nerve were measured before and after experiment.Results After experiment,the concentration of ET,Ang Ⅱ,NO and SCV,amplitude of sensory nerve action potential,latency of sensory nerve action potential,MCV,distal amplitude of motor nerve,and distal latency of motor nerve were (68.84±14.81) pg/ml,(544.01±70.20) pg/ml,(123.73±9.58) nmol/ml,(25.36±6.96) m/s,(1.84±0.65) μV,(4.05±1.04) m/s,(27.40±6.05) m/s,(1.60±0.52) μV,(3.51±1.30) m/s respectively in low temperature group;(70.22±15.02) pg/ml,(540.77±68.25) pg/ml,(129.46±11.99) nmol/ml,(27.69±6.16) m/s,(2.19±0.53)μV,(3.86±0.89) m/s,(30.03±5.21) m/s,(1.65±0.49)μV,(3.36±1.11)m/s respectively in vibration group;(88.47±13.20) pg/ml,(687.38±101.44) pg/ml,(70.66±4.99) nmol/ml,(20.82±3.65)m/s,(1.21±0.64)μV,(5.05±0.94) m/s,(19.97±4.37) m/s,(1.09±0.49)μV,(4.49±1.26) m/s respectively in eombined effect group;compared with pre-experiment,the concentration of ET and Ang Ⅱ in low temperature group,vibration group and combined effect group were increased after experiment,and the NO was decreased (P＜0.05);the nerve conduct velocity and amplitude was decreased and the latency was delayed (P＜0.05).After experiment,the concentrations of ET and Ang Ⅱ in combined effect group were higher than low temperature group and vibration group,and the concentration of NO in combined effect group was lower than low temperature group and vibration group(P＜0.05).After experiment,the SCV and MCV in combined effect group were slower than low temperature group and vibration group;the amplitude of sensory nerve action potential and distal amplitude of moor nerve were less than low temperature group and vibration group;the latency of sensory nerve action potential and distal latency of motor nerve in combined effect group was longer than low temperature group and vibration group.The factorial analysis results indicated the synergistic effect between low temperature and vibration(P＜0.05).Conclusion Vibration-induced peripheral vascular impairment and nerve impairment would be intensified by low temperature.     

振动性血管功能损伤的研究进展

手臂振动(HAV)是常见的职业危害,由其所致的周围血管损伤、神经损伤和骨-关节损伤等表现,统称为手臂振动综合征(HAVS)。在这3大表现中又以振动性血管功能损伤(VVFI)的危害最大、发病最广泛,振动性白指(VWF)是其典型表现。本文对VVFI近年来的研究进展进行综述。1VVFI与内皮素(ET)、一氧化氮(NO)ET与NO主要由血管内皮细胞合成、分泌。ET可通过与内皮细胞上的ET受体结合而产生强烈的缩血管作用,是目前已知最强的收缩血管物质,同时可促进细胞周期调节基因CDK-2及Cyclin-K的表达和血管平滑肌的增殖。KOHOUT等[1]测定严重程度不…     

尿碘和发碘中位值的差异分析

目的分析探讨尿碘和发碘的中位值范围。方法通过对2445例检测样品的检测值的统计分析，来探讨不同年龄段人群的中位值。结果不同年龄段人群的尿碘中位值不同，而发碘的中位值比较接近。结论我们根据发碘的测定值可以探讨本地区的发碘正常值范围。