排序方式: 共有102条查询结果,搜索用时 15 毫秒
21.
Objective To explore the expression and the value of HIF-1α,and ET-1 in judging the prognosis of gastrointestinal stromal tumors (GISTs). Methods The expression of HIF-1α, and ET-1 protein was examined in 76 GISTs by immunohistochemistry S -P methods. Results There was a positive correlation between the expression of HIF-1 α and ET-1 ( P < 0.05 ). The positive expression rate of HIF-1 α and ET-1 was 73.68% (50/76) ,and 65.79% (50/76) respectively,which was related with histologicial grade, tumor diameter, infiltration and metastasis, nuclear division rating of GISTs ( P < 0.05 ), but had no relationship with patients' age, gender, initial position of the tumor ( P > 0.05 ). There was statistically sig-nificant difference in the expression of HIF-1 α and ET-1 in the following groups:among the three classes of very low-risk and low-risk, middle-risk, high-risk, bewteen the diameter < 2 cm and > 5 cm (P < 0.05). The more malignant degree and larger diameter, the more highly positive expression rate ( P < 0.05 ). The positive expression in the groups with infiltration and metastasis, and nuclear division ≥5/50 HP was sig-nificantly higher than the groups without infiltration and metastasis, and nuclear division < 5/50 HP (P < 0.05). Conclusion The expression of HIF-1α had a significant correlation with ET-1. HIF-1α,and ET-1 expression was closely related with the prognosis of GISTs,and can serve as important predictors for survival. 相似文献
22.
目的:探讨胃癌组织mi R-137的表达及其与胃癌细胞侵袭能力间的关系。方法:用q RT-PCR检测胃癌组织与癌旁组织mi R-137的表达,分析mi R-13表达与胃癌临床病理特征的关系;分别用q RT-PCR与Transwell侵袭实验检测3种胃癌细胞(AGS、SGC7901、BGC823)及正常胃黏膜细胞(GES1)mi R-137的表达与穿膜。结果:胃癌组织中mi R-137表达量明显低于癌旁组织(P<0.05),mi R-137表达与胃癌患者T分期有关,T分期越高mi R-137表达量越低(P<0.05);各胃癌细胞mi R-137表达量均低于正常胃黏膜细胞,且胃癌细胞侵袭力越强胃癌细胞mi R-137表达量越低(P<0.05);穿膜细胞数与mi R-137表达量之间呈明显负相关(r=-0.8881,P<0.05)。结论:胃癌组织mi R-137表达降低,且mi R-137表达量越低提示胃癌细胞侵袭能力越强。 相似文献
23.
24.
Objective To explore the expression and the value of HIF-1α,and ET-1 in judging the prognosis of gastrointestinal stromal tumors (GISTs). Methods The expression of HIF-1α, and ET-1 protein was examined in 76 GISTs by immunohistochemistry S -P methods. Results There was a positive correlation between the expression of HIF-1 α and ET-1 ( P < 0.05 ). The positive expression rate of HIF-1 α and ET-1 was 73.68% (50/76) ,and 65.79% (50/76) respectively,which was related with histologicial grade, tumor diameter, infiltration and metastasis, nuclear division rating of GISTs ( P < 0.05 ), but had no relationship with patients' age, gender, initial position of the tumor ( P > 0.05 ). There was statistically sig-nificant difference in the expression of HIF-1 α and ET-1 in the following groups:among the three classes of very low-risk and low-risk, middle-risk, high-risk, bewteen the diameter < 2 cm and > 5 cm (P < 0.05). The more malignant degree and larger diameter, the more highly positive expression rate ( P < 0.05 ). The positive expression in the groups with infiltration and metastasis, and nuclear division ≥5/50 HP was sig-nificantly higher than the groups without infiltration and metastasis, and nuclear division < 5/50 HP (P < 0.05). Conclusion The expression of HIF-1α had a significant correlation with ET-1. HIF-1α,and ET-1 expression was closely related with the prognosis of GISTs,and can serve as important predictors for survival. 相似文献
25.
目的:从切除的人小肠间质瘤(gastrointestinal stromal tumors, GIST)组织建立一株间质瘤细胞系,初步鉴定其生物学特性。方法:取人小肠间质瘤组织切成小块,置于含10%胎牛血清、青霉素、链霉素和庆大霉素的RPMI 1640培养基中进行培养,待细胞长满90%汇合面后消化传代培养,并进行形态学、生长动力学、免疫组织化学(免疫组化)及致瘤性等生物学特性研究。结果:成功建立GIST细胞系,命名为GIST-H1 细胞系。该细胞系已在体外培养生存1年,传60余代。免疫组织化学分析显示该细胞CD117(+),SMA(+),dog-1(+),CD34(-)及S-100(-);该细胞系体外生长的倍增时间为47.5 h;软琼脂集落形成率为24.8%;透射电镜下可观察到该细胞富含线粒体和内质网,多数细胞表面无绒毛,胞核呈卵圆形;染色体核型分析为非整倍体,众数为60~98条;该细胞接种至裸鼠皮下后致瘤性为100%。结论:间质瘤细胞系在体外长期培养后已永生化,形成了可连续传代的细胞系,且具有明显的间质瘤细胞恶性表型特征。 相似文献
26.
目的:探讨大肠癌患者外周血淋巴细胞粘着斑激酶(FAK)的表达及其临床意义。方法 结果 结论 方法:应用流式细胞仪(flow cytometry, FCM)检测40例大肠癌患者及20例正常人外周血淋巴细胞中FAK的表达。结果:大肠癌患者外周血淋巴细胞FAK阳性表达率为60.0%,与正常人(25.0%)比较,差异有显著性意义(P<0.05)。并且外周血淋巴细胞FAK表达与大肠癌临床分期、组织学分化程度、淋巴转移有关。结论:大肠癌患者外周血淋巴细胞FAK异常表达与荷瘤状况有关,对大肠癌的早期诊断、临床分期、组织学分型、淋巴转移的预测等可能有一定帮助。 相似文献
27.
28.
目的系统评价腹腔镜与开腹手术治疗进展期胃癌的疗效。方法检索PubMed、EMBASE、The Cochrane Library和中国期刊全文数据库(CNKI)及中国生物医学期刊文献数据库(CMCC)收录2003年7月至2013年7月发表的有关腹腔镜手术与开腹手术治疗进展期胃癌疗效比较的文献。评估文献质量并提取数据资料,应用Review Manager5.0软件对其进行Meta分析。采用I^2对异质性进行定量分析。采用固定或随机效应模型合并数据。计数资料采用优势比(OR)及95%可信区间(95%CI)表示。结果共纳入文献12篇,其中1篇中文文献,11篇英文文献;1篇随机对照研究,11篇回顾性非随机对照研究。全体研究样本量合计2079例进展期胃癌,其中腹腔镜组882例,开腹组1197例。Meta分析结果显示:腹腔镜组与开腹组的手术时间、术中出血量、术后肛门排气时间、术后经口进食时间、术后住院时间比较,差异有统计学意义(WMD=41.33,-106.00,-0.55,-0.76,-2.62,95%CI:25.44-57.21,-120.71—-91.29,-0.80—-0.29,-1.29—-0.23,-4.05—-1.18,P〈0.05);淋巴结清扫数目及术后并发症发生率比较,差异无统计学意义(WMD=0.22,OR=0.82,95%CI:-1.48~1.93,0.62~1.08,P〉0.05)。结论腹腔镜手术可以运用于进展期胃癌的根治性治疗,与开腹手术比较,在近期疗效上可以获益。 相似文献
29.
30.
腹腔镜胆囊切除术中转小切口胆囊切除术临床应用 总被引:3,自引:0,他引:3
目的探讨腹腔镜胆囊切除术(LC)中转小切口胆囊切除术(MC)临床应用。方法对2 235例LC中转56例MC作回顾分析,LC改MC主要技术是将原剑突下斜行10 mm戳孔沿肋缘下向右延长至5~6 cm进行直视下小切口操作。结果 56例LC例中转为MC操作后均比较顺利切除胆囊,仅4例急性胆囊炎炎症明显,出血量300~400 mL,全组无严重并发症。结论 LC中转MC后操作容易、安全,而且不失微创的理念,对患者有利。 相似文献