全国卫生工作会议综述

在举国上下认真贯彻党的十四大精神,加快改革,扩大开放的大好形势下,1993年全国卫生工作会议于元月中旬在北京举行。会议的主要议题是学习贯彻党的十四大精神,总结交流卫生改革与发展的经验,进一步解放思想,统一认识,研究部署1993年的卫生工作任务。会议在听取卫生部的工作报告和15个省、市的经验交流之后,主要围绕着解放思想,更新观念,卫生事业发展如何同市场经济相适应,如何用好关于第三产业的有关政策,深化卫生改革如何与落实农村卫生、预防保健结合起来,如何坚持两     

抑郁发作自杀未遂患者脑源性神经营养因子水平及其相关因素研究

Objective To investigate the possible role of brain-derived neurotrophic factor(BDNF)in the pathophysiology of attempted suicide in depressive episode patients.Methods The subjects were 23 depressive episode patients who had recently attempted suicide.24 depressive episode patients without suicide attempt.and 30 sex-age-and education matched healthy controls.The Hamihon Depression Rating Scale-24 items(HAMD24),Beck Helpless Rating Scale(BHS)and Self-rating Idea of Suicide Scale (SIOSS)was used to evaluate the severitv of symptoms.The seruln level of BDNF was detected with sandwich ELISA.Pearson correlation coefficients wag used to measure the correlations between serum BDNF and the related illness variables.Results There were significant difierences in the serum level of BDNF between patients with attempted suicide,pailents without suicide attempt and normal controls(F=21.927,P＜0.05).Post hoc analysis showed the serum BDNF levels in patients with attempted suicide [(57 ±16)ng/L]were lower than that in patients without[(75±28)ns/L;P＜0.05],and were lower in patients without suicide attempt[(75 ±28)ng/L]than that in normal controls[(111 ±39)ng/L;P＜0.01].In patients with attempted suicide,the serum BDNF was negatively correlated to the duration of depressive episode(r=-0.541,P=0.008),the mean BHS score(r=-0.494,P=0.017)and the mean SIOSSscore(r=-0.754.P=0.000).Conclusion The results suggest that the decreased serum brain-derived neurotrophic factor is related to the pathophysiology of attempted suicide in depressive episode patients.     

宫颈癌疫苗试验取得可喜结果

如果人类试验能取得与动物试验相同的好结果,可能在3年内获得一种抗宫颈癌疫苗。英国Glasgow大学研究人员研制出一种增强免疫系统以杀伤癌前期肿瘤的疫苗。在有限的试验中发现,此种疫苗能治愈牛肿瘤,这是类似于妇女患宫颈癌之前的肿瘤。     

唾液幽门螺杆菌抗原检测与慢性胃炎活动性及癌前病变关系的研究

目的 评价唾液幽门螺杆菌（Helicobacterpylori，Hp）抗原与慢性胃炎活动性以及胃黏膜癌前病变肠上皮化生与不典型增生的相关性。方法 应用酶联免疫吸附法（ELISA），对2004年6月至2005年6月浙江大学医学院附属第二医院消化内科246例接受胃镜检查患者的唾液标本进行幽门螺杆菌抗原检测，分别比较不同胃病患者唾液中Hp抗原的阳性检出率。结果 慢性活动性胃炎组唾液中Hp抗原阳性检出率为74．29％（26／35）．明显高于慢性非活动性胃炎组46．92％（99／211）（P〈0．05）。慢性胃炎组患者唾液中Hp抗原的阳性检出率为45.98％（80／174），慢性胃炎伴轻度肠上皮化生（肠化）组唾液中Hp抗原阳性检出率为52.63％（20／38），慢性胃炎伴中重度肠化组唾液中Hp抗原阳性检出率为68．18％（15／22），慢性胃炎伴不典型增生组唾液中Hp抗原阳性检出率为83．33％（10／12），结果显示．慢性胃炎伴中重度肠化或不典型增生组与慢性胃炎组相比，差异有统计学意义（P〈0．05）。结论 唾液中存在高Hp检出率现象，1：3腔可能为Hp的重要寄居地．1：3腔内Hp感染程度与胃炎活动程度及部分胃黏膜癌前病变有关，慢性活动性胃炎或伴中重度肠化或不典型增生患者口腔内Hp检出率明显增高，口腔内Hp是否需行根除治疗，值得今后进一步研究探讨。     

应用和推广烧伤皮肤再生医疗技术的体会(二)

目的：通过临床实践总结、分析、认识干细胞与再生医学理论在烧伤创疡中的作用与效果；方法：应用MEBT／MEBO观察烧伤创疡创面的再生修复变化。结果：MEBT／MEBO治疗77种创疡疾病冶愈率达92％以上，有效率达100％。结论：MEBT／MEN)治疗慢性体表性溃疡及皮肤病性皮肤损伤、感染性溃疡效果满意。     

1995～2000年参加全国微生物室间质评活动分析

目的 就我室1995－2000年参加全国微生物室间质评活动进行总结分析，以利于进一步提高我室微生物检验的总体水平。方法 对卫生部临检中心发放的质控菌株按其要求进行分离检测，对我室结果进行分析。结果 1995－2000年我室接收质控菌75株，9株菌未转种成功，鉴定正确 61株，误检菌5株。结论 我室对革兰阳性球菌、非发酵菌、革兰阳性杆菌、革兰阴性球菌鉴定正确率较高。但应加强对培养基质量的控制，以提高对荷养菌的分离和鉴定率。     

水泥型羟基磷灰石人工骨的制备及性能分析

Objective: To prepare hydroxyapatite cement (or calcium phosphate cement,CPC) and analyze its capability. Methods: Tetracalcium phospluge (TTCP ) was prepared by the method of high heat. TTCP reacted with in simulated body situation and produced CPC. Its capability was analyzed by scanning electron microscopy ( SEM), X-ray diffraction( XRD). Its density, absorbing water coefficient, macroporosity and compressive strength were measured also. Results: The main element of CPC is hydroxyapatile (HA), its microstructure comprised of petal crys-tals. The diameter of micropore was 4-10μm, density was 1. 922 g/cm^3, macroporosity was 29. 777%, absorbing coefficient was 15. 503%, compressive strength was 42.70 Mpa. Conclusion: This CPC has three-dimensional spatial structure, its strength meets the need of cancellous bone grafting.     

水泥型羟基磷灰石人工骨的制备及性能分析(英文)

目的:制备水泥型羟基磷灰石人工骨,并进行性能分析。方法:高温法制备出磷酸四钙,然后在模拟体内环境下将其与无水磷酸氢钙发生水化固化反应,合成水泥型羟基磷灰石人工骨,采用X线衍射、扫描电镜观察、体积密度、吸水率、孔隙率及耐压强度测量进行性能分析。结果:该人工骨主要成分为低结晶度的羟基磷灰石;微观结构呈针状或花瓣状晶体构成,微孔直径约4-10 μm,孔隙相互交通;平均体积密度为1.922 g·cm~(-3);平均吸水率为15.503％;孔隙率为29.777％;耐压强度为42.70 MPa。结论:本研究所制人工骨具有三维空间结构,力学性能符合人体非负重骨植骨要求。