An Object-oriented Environment for Developing Finite Element Codes for Multi-disciplinary Applications

The objective of this work is to describe the design and implementation of a framework for building multi-disciplinary finite element programs. The main goals are generality, reusability, extendibility, good performance and memory efficiency. Another objective is preparing the code structure for team development to ensure the easy collaboration of experts in different fields in the development of multi-disciplinary applications.     

Modification of isoprene rubber by in situ silica generation

BACKGROUND: The reinforcement of elastomers by the addition of fillers is one of the most important aspects in rubber science and technology. In order to optimise the filler–polymer interface, innovative in situ generation of silica within isoprene rubber was carried out by means of a bottom‐up approach through a sol–gel process starting from tetraethoxysilane as silica precursor. The main aim was the study of the effect of the silica concentration and of the presence of coupling agent on the morphology and the dynamic mechanical behaviour of the composites. RESULTS: The in situ generated silica particles were homogeneously dispersed in the vulcanised rubber with dimensions from a few nanometres to the submicrometre scale. In the presence of coupling agent a good polymer–filler adhesion was observed. The dynamic mechanical behaviour was nonlinear for silica contents higher than 20 wt%. In this range of compositions silica exerted a marked reinforcement on the low‐amplitude storage modulus, which is related to the silica content according to the Huber–Vilgis model. CONCLUSION: Isoprene rubber can be effectively reinforced by the in situ generation of silica for silica contents higher than 20 wt%, and the interaction at the silica–rubber interface can be optimised by using suitable coupling agents. Copyright © 2009 Society of Chemical Industry     

Performance Evolution of Mobile Web-Based Services

The mobile Web's widespread diffusion opens many interesting design and management issues about server infrastructures that must satisfy present and future client demand. Future mobile Web-based services will have growing computational costs. Even requests for the same Web resource will require services to dynamically generate content that takes into account specific devices, user profiles, and contexts. The authors consider the evolution of the mobile Web workload and trends in server and client devices with the goal of anticipating future bottlenecks and developing management strategies.     

Attachment concept for the “multi module segments” in a pulsed DEMO reactor

The pulsed thermonuclear demonstration reactor (DEMO) features challenging operational conditions such as high neutron fluxes, high temperatures, and significant thermo-mechanical stresses. These conditions do not require only a selection of advanced structural materials, but also the development of reliable means to assemble the in-vessel components together; allowing thermal expansions, disassembly, and maintenance in attractive scenarios. Over the course of DEMO lifetime, the materials are subjected to embrittlement by neutron irradiation, swelling, considerable thermo-mechanical fatigue and creep. Traditional joining methods may be rarely used in the harsh fusion environment to assemble different components. In addition any proposed layout should cope with the limited space available inside the vacuum vessel (VV).The objective of this study is to review the proposed attachment systems (developed within the latest European DEMO Conceptual Study) for the vertical segmentation concept called “multi module segments” (MMS). In order to find some place to house the attachments the blanket is cut respecting the Tritium Breeding Ratio limit for tritium self sufficiency. The conditions, neutronic and thermal, in which the attachments are supposed to operate, are calculated. The effects of pulsed operations have also been taken into account. The design of the attachments with the available structural materials with and without an active cooling system is analysed and a new concept for plug/unplug attachments is also suggested.     

Inhibition of Ceramide Synthesis Reduces α-Synuclein Proteinopathy in a Cellular Model of Parkinson’s Disease

Parkinson’s disease (PD) is a proteinopathy associated with the aggregation of α-synuclein and the formation of lipid–protein cellular inclusions, named Lewy bodies (LBs). LB formation results in impaired neurotransmitter release and uptake, which involve membrane traffic and require lipid synthesis and metabolism. Lipids, particularly ceramides, are accumulated in postmortem PD brains and altered in the plasma of PD patients. Autophagy is impaired in PD, reducing the ability of neurons to clear protein aggregates, thus worsening stress conditions and inducing neuronal death. The inhibition of ceramide synthesis by myriocin (Myr) in SH-SY5Y neuronal cells treated with preformed α-synuclein fibrils reduced intracellular aggregates, favoring their sequestration into lysosomes. This was associated with TFEB activation, increased expression of TFEB and LAMP2, and the cytosolic accumulation of LC3II, indicating that Myr promotes autophagy. Myr significantly reduces the fibril-related production of inflammatory mediators and lipid peroxidation and activates NRF2, which is downregulated in PD. Finally, Myr enhances the expression of genes that control neurotransmitter transport (SNARE complex, VMAT2, and DAT), whose progressive deficiency occurs in PD neurodegeneration. The present study suggests that counteracting the accumulation of inflammatory lipids could represent a possible therapeutic strategy for PD.     

Dose-dependent inhibition of cell proliferation induced by lipid peroxidation products in rat hepatoma cells after enrichment with arachidonic acid

Polyunsaturated fatty acids (PUFA) are important constituents of membrane phospholipids, whose levels are decreased in some tumor cells. This deficiency may cause alterations in signal transduction and an interruption of normal cellular events. The enrichment of tumor cells with PUFA may stimulate or inhibit tumor growth, probably depending on the type of PUFA and the cellular concentration of aldehydes derived from restored lipid peroxidation. We examined the effect of several doses of prooxidant on the growth of hepatoma cells with different aldehyde dehydrogenase activities, enriched with arachidonic acid. Two doses of prooxidant were sufficient to reduce growth of hepatoma cells with low aldehyde dehydrogenase activity, whereas three doses were necessary for those with high enzyme activity. In both cases, lipid peroxidation products blocked the cells in the S phase.     

Transport in silicon nanowires: role of radial dopant profile

We consider the electronic transport properties of phosphorus (P) doped silicon nanowires (SiNWs). By combining ab initio density functional theory (DFT) calculations with a recursive Green’s function method, we calculate the conductance distribution of up to 200 nm long SiNWs with different distributions of P dopant impurities. We find that the radial distribution of the dopants influences the conductance properties significantly: surface doped wires have longer mean-free paths and smaller sample-to-sample fluctuations in the cross-over from ballistic to diffusive transport. These findings can be quantitatively predicted in terms of the scattering properties of the single dopant atoms, implying that relatively simple calculations are sufficient in practical device modeling.     

Pulmonary veins: Magnetic resonance angiography anatomy

Objective: to optimize magnetic resonance angiography technique for the selective study of the anatomy of pulmonary veins. Materials and methods: twenty consecutive patients (13 males and seven females; mean age 30.5 years) prospectively studied were enrolled. Magnetic resonance angiography was performed using a 1 T superconductive magnet and three dimensional time of flight technique (3D TOF). Imaging with steady-state free precession sequence during intravenous infusion of contrast medium (Gd DTPA 0.2 mmol kg^-1) administration was employed using the following parameters: FA 20°, TR 58 ms, TE 6 ms, MA 192 x 256, NEX 1, slice thickness 4 mm and slice orientation on the Z and F planes. Results: in the right lung magnetic resonance angiography well visualized 124 venous vessels on the coronal plane versus 106 venous vessels on the sagittal plane, whereas in the left lung magnetic resonance angiography visualized 96 vessels on the coronal plane versus 44 visualized on the sagittal plane. Our data suggest that 3D time of flight with contrast medium is a promising evaluation technique for pulmonary veins, and that combined evaluation of acquisitions on coronal and sagittal planes allows the visualization of a higher number of venous vessels. Conclusion: 3D time of flight with contrast medium and without breath-hold permits to visualize a venous vascular map of the lungs. © 1998 Elsevier Science B.V. All rights reserved.     

On the use of CrN/Cr and CrN interlayers in hot filament chemical vapour deposition (HF-CVD) of diamond films onto WC-Co substrates

CrN/Cr-based films were deposited using PVD-arc technique onto Co-cemented tungsten carbide (WC-Co) substrates and, then, seeded with diamond powder suspension or mechanically treated by Fluidized Bed Peening (FBP) of brittle diamond powders. Multilayered coatings were obtained from the superimposition of 4 µm-thick diamond coatings, deposited on the PVD interlayer using hot filament chemical vapour deposition (HFCVD). The effectiveness of fluidized bed peened CrN/Cr interlayers on the adhesion enhancement of diamond on WC-Co substrates was studied and compared to diamond coated WC-Co substrates with unpeened CrN/Cr or CrN interlayers, or pre-treated with two-step chemical etching (Murakami's reagent and Caro's acid, MC-treatment).In particular, growth, morphology, wear endurance and adhesion of the CVD deposited diamond films onto peened CrN/Cr interlayer were looked into. Diamond coatings on peened CrN/Cr interlayers exhibited a rougher surface morphology than as-prepared CrN/Cr films as a result of the surface roughening of the ductile Cr layer produced by the repeated impacts on it of the diamond powders during FBP. FBP was found to be a necessary step in improving the scarce adhesion of CVD diamond onto CrN/Cr-interlayer.However, the use of FB peened CrN/Cr interlayer did not represent the best way to pre-treat WC-Co substrates, as the unpeened single-layer CrN, or the use of MC pretreatment, was found to ensure better adhesion and wear endurance.