Representations by Contact and Intersection of Segments

A necessary and sufficient condition is given for a connected bipartite graph to be the incidence graph of a contact family of segments and points. We deduce that any four-connected three-colorable plane graph is the contact graph of a family of segments and that any four-colored planar graph without an induced C₄ using four colors is the intersection graph of a family of straight line segments.     

流溪河灌区工程渠首枢纽计算机监控系统开发与研建

流溪河渠首枢纽计算机监控系统在自行开发的现场总线工业局域网及专用智能终端、冗余管理和故障诊断专家系统的硬件环境下，在分别由监控系统（含设备层与上位机在线监控系统）和管理系统（由离线管理与服务器上的查询服务系统组成）软件的支持下，实现了对枢纽工程3座水闸47孔闸门的运行和管理，具有自动监测、自动量水、自动控制及系统重构等功能．现已以每天24h不间断地运行了2年，顺利地完成了枢纽工程的调洪、调水等日常调度与运行工作．     

Natural and induced tolerance in an immune network model

It has been proposed that the immune system can be partitioned into central and peripheral immune systems. Recently, Carneiro et al. (1996a, b) proposed a network, model incorporating B and T lymphocytes that explicitly accounts for that partition. This model however, had some limitations that are tackled here. Two main changes were introduced: the average idiotypic connectivity is now an explicit function of time based on empirical evidence; and the activation of T lymphocytes by antigen is described by a log-bell shaped dose response curve. The new model, which also accounts for the CIS and PIS distinction, shows more reasonable results since the frequencies of tolerant, immune or autoimmune responses to an antigen are now correct. The model provides a new interpretation for tolerance induction during the neonatal period, and for the adult tolerance by low or high doses of antigen. It predicts that natural tolerance for antigens available during the neonatal period can be kept indefinitely upon their removal, while tolerance induced in the adult stages is rapidly lost upon transient removal of the antigen. A semiquantitative analysis of the model provides a simple explanation for the different results in terms of the frequency at which a limited set of canonical connectivity structures emerge during ontogenesis.     

Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid

Patients with acute promyelocytic leukemia (APL) usually relapse after all-trans retinoic acid (RA) treatment because this therapy fails to eradicate the malignant clone. Our data showed that KH 1060 and other 20-epi vitamin D3 analogs alone were potent inhibitors of clonal growth of NB4 cells, an APL cell line (ED50, approximately 5 x 10(-11) M). The combination of KH 1060 and 9-cis-RA synergistically and irreversibly enhanced this effect. Neither KH 1060 nor 9-cis-RA (10(-6) M, 3 d) were strong inducers of differentiation of NB4 cells. However, 98% of the cells underwent differentiation to a mature phenotype with features of both granulocytes and monocytes after exposure to a combination of both compounds. Apoptosis only increased after incubation of NB4 cells with 9-cis-RA alone (28%) or with a combination of 9-cis-RA plus KH1060 (32%). Immunohistochemistry showed that the bcl-2 protein decreased from nearly 100% of the wild-type NB4 cells to 2% after incubation with a combination of KH 1060 and 9-cis-RA, and the bax protein increased from 50% of wild-type NB4 cells to 92% after culture with both analogs (5 x 10(-7) M, 3 d). Western blot analysis paralleled these results. Studies of APL cells from one untreated individual paralleled our results with NB4 cells. Taken together, the data demonstrated that nearly all of the NB4 cells can be irreversibly induced to differentiate terminally when exposed to the combination of KH 1060 and 9-cis-RA.     

The effect of a two-week anti-orthostatic hypokinesia on the cardiac function and on the latter''s regulation in monkeys

Medical practice guidelines are being developed rapidly and advocated as a crucial component in transforming and improving the delivery of health care services. However, little is known about the ability of hospitals to institute guidelines outside of experimental settings. This article approaches guideline implementation from the viewpoint of process innovation assimilation and presents specific recommendations for organizational tactics leading to successful implementation of practice guidelines.     

ZH150重油钢包烘烤装置的研制与应用

ＺＨ１５０重油钢包烘烤装置具有点火方便，雾化好，燃烧稳定，燃烧效率高，火焰刚性好，调节性能好等优点，适合于钢包的烘烤，也可应用在基他工业炉窑中，该装置用蒸汽或压缩空气作为雾化介质，能燃用柴油，原油，重油，渣油等液体燃料，介绍了该装置的基本结构，工作原理，工作特点及设计对策，以及在生产中的应用情况。     

一种新的坡位定量描述方法及其与滑坡发生的关系

滑坡发生与地形因子的关系是区域滑坡静态规律研究的重点,但以往的研究多注重考虑其与反映几何形态的基本地形属性因子(几何形态属性因子)之间的关系,如坡度和坡向等。首先提出一种新的基于子流域内相对位置定量描述坡位(相对位置因子)的方法,并以温州地区瓯江流域1990~2001年发生的滑坡为研究对象,使用证据权法对比滑坡发生与两种不同类型地形因子之间的关系。结果表明,相对位置因子与滑坡发生的相关性大于滑坡危险性评价经常使用的几何形态属性因子;并且滑坡大多发生在定量坡位值较低的区域,这些地区处在下游,遭受流水侵蚀的强度更大、频率更高。