Diagnosis and treatment of aortic valve stenosis

The present review has attempted to summarize the classic symptoms and signs of aortic valve stenosis, especially in an adult. It is emphasized that all the classic signs rarely are present and their absence may mislead an unwary clinician. The diagnostic help provided by noninvasive tests, including echocardiography and phonocardiography, has been emphasized. A need for cardiac catheterization and angiography in most patients prior to corrective surgery is stressed. The natural history of the disease without operative intervention is dim and a significant risk of sudden death exists. The current surgical approach with immediate and long-term results is summarized. Finally, attention has been drawn to the special clinical circumstances when the aortic valve stenosis provides a strinkingly different clinical picture. We cannot find a better way to end this review than by quoting a warning note given by Thomas Lewis in 1920: "It is the faint cry of an anguished and fast failing muscle, which, when it comes, all should strain to hear, for it is not long repeated. A few months, a few years at most, and the end comes."     

Improving Water Supply Outlook in Korea with Ensemble Streamflow Prediction

Abstract

The purpose of this study is to propose an alternative forecasting approach for improving the current water supply outlook in Korea. Using a rainfall-runoff model, the existing technique for the water supply outlook in Korea produces monthly low, average, and high runoff forecasts. The proposed technique is called Ensemble Streamflow Prediction (ESP), and is currently implemented by the National Weather Service in the U.S.A. ESP appears particularly valid in Korea where the historical rainfall record is much more comprehensive than the historical streamflow record. This study applies ESP to runoff forecasting for a river basin in Korea to examine its applicability. An ensemble of one-month ahead runoff forecasts at the Gongju gauging station in the Keum River basin, Korea, was generated for each month. The resulting ESP forecasts were compared with the corresponding observed runoff data as well as the existing forecasts. Although this study is limited to one case study, the following conclusions can be made: (1) the ESP technique dominates the existing forecasting techniques in terms of both systematic and random errors; and (2) ESP is more accurate when high flows occur.     

Part-based spatio-temporal model for multi-person re-identification

In this paper we propose an adaptive part-based spatio-temporal model that characterizes person’s appearance using color and facial features. Face image selection based on low level cues is used to select usable face images to build a face model. Color features that capture the distribution of colors as well as the representative colors are used to build the color model. The model is built over a sequence of frames of an individual and hence captures the characteristic appearance as well as its variations over time. We also address the problem of multiple person re-identification in the absence of calibration data or prior knowledge about the camera layout. Multiple person re-identification is a open set matching problem with a dynamically evolving and open gallery set and an open probe set. Re-identification is posed as a rectangular assignment problem and is solved to find a bijection that minimizes the overall assignment cost. Open and closed set re-identification is tested on 30 videos collected with nine non-overlapping cameras spanning outdoor and indoor areas, with 40 subjects under observation. A false acceptance reduction scheme based on the developed model is also proposed.     

Electron Acoustic Solitons

Electron acoustic solitons in collisionless and weakly relativistic plasmas are studied. The Krylov–Bogoliubov–Mitropolsky perturbative technique is employed to obtain the nonlinear Schrodinger wave equation. We have numerically investigated modulational instability for different values of the streaming velocity. Graphs have been plotted to see the change in amplitude and inverse width by varying different plasma parameters.     

Determining driver visual attention with one camera

This paper presents a system for analyzing human driver visual attention. The system relies on estimation of global motion and color statistics to robustly track a person's head and facial features. The system is fully automatic, it can initialize automatically, and reinitialize when necessary. The system classifies rotation in all viewing directions, detects eye/mouth occlusion, detects eye blinking and eye closure, and recovers the three dimensional gaze of the eyes. In addition, the system is able to track both through occlusion due to eye blinking, and eye closure, large mouth movement, and also through occlusion due to rotation. Even when the face is fully occluded due to rotation, the system does not break down. Further the system is able to track through yawning, which is a large local mouth motion. Finally, results are presented, and future work on how this system can be used for more advanced driver visual attention monitoring is discussed.     

Editorial

Machine Vision and Applications -     

Tri-view morphing

This paper presents an efficient image-based approach to navigate a scene based on only three wide-baseline uncalibrated images without the explicit use of a 3D model. After automatically recovering corresponding points between each pair of images, an accurate trifocal plane is extracted from the trifocal tensor of these three images. Next, based on a small number of feature marks using a friendly GUI, the correct dense disparity maps are obtained by using our trinocular-stereo algorithm. Employing the barycentric warping scheme with the computed disparity, we can generate an arbitrary novel view within a triangle spanned by three camera centers. Furthermore, after self-calibration of the cameras, 3D objects can be correctly augmented into the virtual environment synthesized by the tri-view morphing algorithm. Three applications of the tri-view morphing algorithm are demonstrated. The first one is 4D video synthesis, which can be used to fill in the gap between a few sparsely located video cameras to synthetically generate a video from a virtual moving camera. This synthetic camera can be used to view the dynamic scene from a novel view instead of the original static camera views. The second application is multiple view morphing, where we can seamlessly fly through the scene over a 2D space constructed by more than three cameras. The last one is dynamic scene synthesis using three still images, where several rigid objects may move in any orientation or direction. After segmenting three reference frames into several layers, the novel views in the dynamic scene can be generated by applying our algorithm. Finally, the experiments are presented to illustrate that a series of photo-realistic virtual views can be generated to fly through a virtual environment covered by several static cameras.     

From template to image: reconstructing fingerprints from minutiae points

Most fingerprint-based biometric systems store the minutiae template of a user in the database. It has been traditionally assumed that the minutiae template of a user does not reveal any information about the original fingerprint. In this paper, we challenge this notion and show that three levels of information about the parent fingerprint can be elicited from the minutiae template alone, viz., 1) the orientation field information, 2) the class or type information, and 3) the friction ridge structure. The orientation estimation algorithm determines the direction of local ridges using the evidence of minutiae triplets. The estimated orientation field, along with the given minutiae distribution, is then used to predict the class of the fingerprint. Finally, the ridge structure of the parent fingerprint is generated using streamlines that are based on the estimated orientation field. Line integral convolution is used to impart texture to the ensuing ridges, resulting in a ridge map resembling the parent fingerprint. The salient feature of this noniterative method to generate ridges is its ability to preserve the minutiae at specified locations in the reconstructed ridge map. Experiments using a commercial fingerprint matcher suggest that the reconstructed ridge structure bears close resemblance to the parent fingerprint     

Molecular Pathways in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension is a multifactorial, chronic disease process that leads to pulmonary arterial endothelial dysfunction and smooth muscular hypertrophy, resulting in impaired pliability and hemodynamics of the pulmonary vascular system, and consequent right ventricular dysfunction. Existing treatments target limited pathways with only modest improvement in disease morbidity, and little or no improvement in mortality. Ongoing research has focused on the molecular basis of pulmonary arterial hypertension and is going to be important in the discovery of new treatments and genetic pathways involved. This review focuses on the molecular pathogenesis of pulmonary arterial hypertension.     

Novel Systemic Treatment Modalities Including Immunotherapy and Molecular Targeted Therapy for Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers worldwide. More than half of patients with HNSCC eventually experience disease recurrence and/or metastasis, which can threaten their long-term survival. HNSCCs located in the oral cavity and larynx are usually associated with tobacco and/or alcohol use, whereas human papillomavirus (HPV) infection, particularly HPV16 infection, is increasingly recognized as a cause of oropharyngeal HNSCC. Despite clinical, histologic, and molecular differences between HPV-positive and HPV-negative HNSCCs, current treatment approaches are the same. For recurrent disease, these strategies include chemotherapy, immunotherapy with PD-1-inhibitors, or a monoclonal antibody, cetuximab, that targets epidermal growth factor; these therapies can be administered either as single agents or in combination. However, these treatment strategies carry a high risk of toxic side effects; therefore, more effective and less toxic treatments are needed. The landscape of HNSCC therapy is changing significantly; numerous clinical trials are underway to test novel therapeutic options like adaptive cellular therapy, antibody-drug conjugates, new targeted therapy agents, novel immunotherapy combinations, and therapeutic vaccines. This review helps in understanding the various developments in HNSCC therapy and sheds light on the path ahead in terms of further research in this field.