How old is the Web? Characterizing the age and the currency of the European scientific Web

The aim of this paper is to model and study the age of the Web using a sample of about four million of web pages from the 16 European Research Area countries obtained during 2004 and 2005. Web page time-stamp (date when the web pages were created or last changed for last time), format and size in bytes data have been analysed. Several indicators are introduced to measure longitudinal aspects of the Web. Half-age is proposed as a measure of the age distribution because this is found to be exponential. “Web Update Index” and “Lifespan Index” are introduced to measure the changing rate of a small sample over time. Results show that the British Web space has the youngest Web pages while the Greek and Belgian ones have the oldest. The study also compared Web pages topics and found that Biology pages are more stable than Physics pages.     

A log-extended Weibull regression model

A bathtub-shaped failure rate function is very useful in survival analysis and reliability studies. The well-known lifetime distributions do not have this property. For the first time, we propose a location-scale regression model based on the logarithm of an extended Weibull distribution which has the ability to deal with bathtub-shaped failure rate functions. We use the method of maximum likelihood to estimate the model parameters and some inferential procedures are presented. We reanalyze a real data set under the new model and the log-modified Weibull regression model. We perform a model check based on martingale-type residuals and generated envelopes and the statistics AIC and BIC to select appropriate models.     

Interconnection and damping assignment passivity-based control of mechanical systems with underactuation degree one

Interconnection and damping assignment passivity-based control is a new controller design methodology developed for (asymptotic) stabilization of nonlinear systems that does not rely on, sometimes unnatural and technique-driven, linearization or decoupling procedures but instead endows the closed-loop system with a Hamiltonian structure with a desired energy function-that qualifies as Lyapunov function for the desired equilibrium. The assignable energy functions are characterized by a set of partial differential equations that must be solved to determine the control law. We prove in this paper that for a class of mechanical systems with underactuation degree one the partial differential equations can be explicitly solved. Furthermore, we introduce a suitable parametrization of assignable energy functions that provides the designer with a handle to address transient performance and robustness issues. Finally, we develop a speed estimator that allows the implementation of position-feedback controllers. The new result is applied to obtain an (almost) globally stabilizing scheme for the vertical takeoff and landing aircraft with strong input coupling, and a controller for the pendulum in a cart that can swing-up the pendulum from any position in the upper half plane and stop the cart at any desired location. In both cases we obtain very simple and intuitive position-feedback solutions.     

Stabilization of a class of underactuated mechanical systems via interconnection and damping assignment

We consider the application of a formulation of passivity-based control (PBC), known as interconnection and damping assignment (IDA) to the problem of stabilization of underactuated mechanical systems, which requires the modification of both the potential and the kinetic energies. Our main contribution is the characterization of a class of systems for which IDA-PBC yields a smooth asymptotically stabilizing controller with a guaranteed domain of attraction. The class is given in terms of solvability of certain partial differential equations. One important feature of IDA-PBC, stemming from its Hamiltonian formulation, is that it provides new degrees of freedom for the solution of these equations. Using this additional freedom, we are able to show that the method of "controlled Lagrangians"-in its original formulation-may be viewed as a special case of our approach. As illustrations we design asymptotically stabilizing IDA-PBCs for the classical ball and beam system and a novel inertia wheel pendulum.     

Component-Based Derivation of a Parallel Stiff ODE Solver Implemented in a Cluster of Computers

A component-based methodological approach to derive distributed implementations of parallel ODE solvers is proposed. The proposal is based on the incorporation of explicit constructs for performance polymorphism into a methodology to derive group parallel programs of numerical methods from SPMD modules. These constructs enable the structuring of the derivation process into clearly defined steps, each one associated with a different type of optimization. The approach makes possible to obtain a flexible tuning of a parallel ODE solver for several execution contexts and applications. Following this methodological approach, a relevant parallel numerical scheme for solving stiff ODES has been optimized and implemented on a PC cluster. This numerical scheme is obtained from a Radau IIA Implicit Runge–Kutta method and exhibits a high degree of potential parallelism. Several numerical experiments have been performed by using several test problems with different structural characteristics. These experiments show satisfactory speedup results.     

The adjuvants aerosil 200 and Gelita-Sol-P influence on the technological characteristics of spray-dried powders from Passiflora edulis var. flavicarpa

Passiflora edulis (passionflower) is a plant widely used in the Brazilian popular medicine and phytopharmaceutical industry for its sedative activity. This work refers to the development of spray-dried powders (SDPs) from the 40% ethanolic extractive solution of P. edulis aerial parts. The SDPs were prepared with a Büchi 190 Mini-spray dryer using as drying adjuvants Aerosil 200 alone (SDP1), an Aerosil 200: Gelita-Sol-P (1:1) mixture (SDP2) and an Aerosil 200:Gelita-Sol-P (1:3) mixture (SDP3). All the powders were obtained using 40 parts adjuvant and 60 parts extract dried residue. The comparison criteria applied were particle size distribution, hygroscopicity at 95%, 60%, and 35% relative humidity (RH), as well as the flavonoid process recovery. The particle size distributions were analyzed by way of (a) normal distribution parameters, (b) the RRSB grid and (c) considering diameter values in terms of an equivalent sphere. All the powders presented nonnormal distribution, and the RRSB analysis appeared to be, therefore, the analysis method of choice. The total flavonoid recovery was around 80%, and it was practically not affected by the SDP1, SDP2, and SDP3 compositions. At the 60% and 90% RH atmospheres, the SDP3 and SDP2 moisture uptakes were higher than that of the SDP1. All the formulations were, on the contrary, stable at 35% RH, showing a slight moisture loss tendency. The results showed in sum that the SDP prepared using Aerosil 200 as the drying adjuvant alone presented the best technological characteristics of all.     

Treatment of Ph1-positive chronic myelogenous leukemia in children: comparison between allogeneic bone marrow transplantation and conventional chemotherapy. Spanish Working Party for BMT in Children (GETMON)

BACKGROUND AND OBJECTIVE: To compare the estimated survival and disease-free survival between children with Ph1-positive chronic myeloid leukemia treated with allogeneic bone marrow transplantation or conventional chemotherapy. DESIGN AND METHODS: In this retrospective study we compared the results obtained in a group of 14 children who received allogeneic bone marrow transplantation (BMT) between 1983 and 1993, and another group of 27 children treated with busulfan, hydroxyurea or alpha-interferon during the same time period. Patients were transplanted at a median of 7 months from diagnosis and all except one were in their first chronic phase. Conditioning consisted in total body irradiation and cyclophosphamide in 12 cases, and busulfan was added in two. RESULTS: Of the 14 patients treated with BMT, two died of transplant-related complications and two relapsed 18 and 48 months after the BMT. Ten children remain alive and disease free at a median follow up of 60 months. The probability of DFS at 5 years is 70%. Of the 27 patients treated with chemotherapy, 22 have died at a median of 36 months from diagnosis. The probability of survival at 5 years is 5% versus 83% for the BMT group (p = 0.001). INTERPRETATION AND CONCLUSIONS: Allogeneic BMT is a safe and very effective treatment for Ph-positive CML in children. Patients who have an HLA-identical sibling donor must receive a transplant as soon as possible after being diagnosed.     

Convectively driven polymerase chain reaction thermal cycler

We have fabricated a low-cost disposable polymerase chain reaction thermal chamber that uses buoyancy forces to move the sample solution between the different temperatures necessary for amplification. Three-dimensional, unsteady finite element modeling and a simpler 1-D steady-state model are used together with digital particle image velocimetry data to characterize the flow within the device. Biological samples have been amplified using this novel thermal chamber. Time for amplification is less than 30 min. More importantly, an analysis of the energy consumption shows significant improvements over current technology.     

Mobile Learning

Works in progress from selected papers presented at the 2006 IADIS International Conference on Mobile Learning provide an overview of the diverse research being conducted in this field.