Comparison of aspirin with a thromboxane antagonist for patients with prolonged chest pain and ST segment depression

AIM: To compare a thromboxane antagonist (GR3219) with aspirin in patients with prolonged chest pain and ST segment depression to see if the frequency of attacks of chest pain was reduced. METHODS: The trial was part of a study comparing GR3219 with aspirin, and streptokinase with placebo and comprised the GR3219/aspirin leg. Thirty one patients were randomly assigned to GR3219 80 mg twice daily and 28 to aspirin 300 mg daily. The patients were under the age of 76 and admitted to a coronary care unit within 6 hours of continuous chest pain. The ECG showed at least 1 mm of flat or down-going ST segment. The patients kept diaries of their pain over the subsequent 31 days. RESULTS: Seventy percent of patients developed further chest pain. There was no difference between the pattern of recurrent chest pain according to which drug was used. CONCLUSIONS: The hypothesis that specific thromboxane A blockade with GR3219 would be more efficacious than aspirin was not supported by these results.     

Sensory and objective characteristics of broiler meat from commercial broilers fed rendered whole-hen meal

A 40-year-old Japanese man with psoriatic arthritis (PA) involving the spine, sacroiliac and peripheral joints presented with dyspnoea and ankle oedema. Blood pressure was 180/110 and 114/80 mmHg in the right and left upper arms, respectively. Examinations showed left ventricular dilatation and diffuse hypokinesis of the left ventricle, with no involvement of the coronary arteries. Aortography detected total occlusion of the left subclavian artery and stenosis of the origin at the right renal artery. Dilated cardiomyopathy and Takayasu's arteritis associated with PA was diagnosed. A few cases of PA have been reported in association with cardiovascular diseases, but the association of these three diseases has not been documented in the literature to date. Dermatologists need to be aware of cardiovascular manifestations in patients with PA, because cardiovascular diseases are not rare in other seronegative spondyloarthropathies.     

Measurements of the suitability of large rock salt formations for radio detection of high-energy neutrinos

We have investigated the possibility that large rock salt formations might be suitable as target masses for detection of neutrinos of energies about 10 PeV and above. In neutrino interactions at these energies, the secondary electromagnetic cascade produces a coherent radio pulse well above ambient thermal noise via the Askaryan effect. We describe measurements of radio-frequency attenuation lengths and ambient thermal noise in two salt formations. Measurements in the Waste Isolation Pilot Plant, located in an evaporite salt bed in Carlsbad, NM yielded short attenuation lengths, 3–7 m over 150–300 MHz. However, measurements at United Salt's Hockley mine, located in a salt dome near Houston, Texas yielded attenuation lengths in excess of 250 m at similar frequencies. We have also analyzed early ground-penetrating radar data at Hockley mine and have found additional evidence for attenuation lengths in excess of several hundred meters at 440 MHz. We conclude that salt domes, which may individually contain several hundred cubic kilometer water-equivalent mass, provide attractive sites for next-generation high-energy neutrino detectors.     

Measurement and nonmeasurement processes with negative affectivity and employee attitudes.

The partial-correlation approach to investigating negative affectivity (NA) is discussed, and 2 alternative latent-variable techniques are presented. The results of these 3 analytic techniques were compared using a data set consisting of NA, job satisfaction, affective commitment, role stressors, leader-member exchange, and job complexity. The findings using the partial-correlation technique supported a biasing effect of NA on relationships between the substantive variables. Alternatively, although 2 latent-variable approaches provided evidence consistent with the measurement contamination and substantive influences of NA, relationships between the predictors and outcomes were not biased by NA. Both the measurement and substantive relationships effects of NA found in this study and implications for future research on self-reports are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of exogenous testosterone on prostate volume, serum and semen prostate specific antigen levels in healthy young men

PURPOSE: We investigate and define the effects of exogenous testosterone on the normal prostate. MATERIALS AND METHODS: A total of 31 healthy volunteers 21 to 39 years old were randomized to receive either 100, 250 or 500 mg. testosterone via intramuscular injection once a week for 15 weeks. Baseline measurements of serum testosterone, free testosterone and prostate specific antigen (PSA) were taken at week 1. Semen samples were also collected for PSA content and prostate volumes were determined by transrectal ultrasound before testosterone injection. Blood was then drawn every other week before each testosterone injection for the 15 weeks, every other week thereafter until week 28 and again at week 40. After the first 15 weeks semen samples were again collected, and prostate volumes were determined by repeat transrectal ultrasound. RESULTS: Free and total serum testosterone levels increased significantly in the 250 and 500 mg. dose groups. No significant change occurred in the prostate volume or serum PSA levels at any dose of exogenous testosterone. Total semen PSA levels decreased following administration of testosterone but did not reach statistical significance. CONCLUSIONS: Despite significant elevations in serum total and free testosterone, healthy young men do not demonstrate increased serum or semen PSA levels, or increased prostate volume in response to exogenous testosterone injections.     

Paradoxes of GP fundholding: contracting for community health services in the British National Health Service

The expansion of GP fundholding (GPFH) is central to the British government's attempt to maintain the revolution under way in the National Health Service (NHS). Evaluations of the NHS reforms have portrayed GPFH as an important mechanism for competition, and GPFH's bargaining power is reported to have secured significant changes in health service provision. However, these developments have been acknowledged to be less applicable in relation to community health services (CHS) than acute hospital services. On the basis of case studies of the process of contracting for CHS, GPFHs are shown to display ambivalent and sometimes contradictory views which have to be related to broader policy developments in general practice and primary care. Although this paper focuses on the British situation, many of the issues raised by reforms in primary and community health services have implications for developments in other Western health care systems.     

Size does matter!: The mass of information collected by US researchers has enabled the development of an economic simulation model for powder injection moulding…

There are around 150 variables in powder injection moulding (PIM) production so developing an economic model to help the designer understand PIM production costs will provide a great boost to PIM producers in making informed decisions on the viability, or otherwise, of targeted components.