High drive current NMOS with Si-SiGe heterostructure low electric field channel

A drive-current enhancement in NMOS with a compressively strained SiGe structure, which had been a difficult challenge for CMOS integration with strained SiGe high-hole-mobility PMOS, was successfully achieved using a Si-SiGe heterostructure low electric field channel of optimum thickness. A 4-nm-thick Si low-field-channel NMOS with a 4-nm-thick Si/sub 0.8/Ge/sub 0.2/ layer improved drive current by 10% with a 20% reduction in gate leakage current compared with Si-control, while suppressing threshold-voltage rolloff characteristic degradation, and demonstrated excellent I/sub on/--I/sub off/ characteristics of I/sub on/ = 1 mA//spl mu/m for I/sub off/ = 100 nA//spl mu/m. These results are the best in ever reported NMOS with a compressively strained SiGe structure and indicate that a Si-SiGe heterostructure low-field-channel NMOS integrated with a compressively strained SiGe channel PMOS is a promising candidate for high-speed CMOS in 65-nm node logic technology.     

Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2

ALG-2, a 22-kDa penta-EF-hand protein, is involved in cell death, signal transduction, membrane trafficking, etc., by interacting with various proteins in mammalian cells in a Ca²⁺-dependent manner. Most known ALG-2-interacting proteins contain proline-rich regions in which either PPYPXnYP (type 1 motif) or PXPGF (type 2 motif) is commonly found. Previous X-ray crystal structural analysis of the complex between ALG-2 and an ALIX peptide revealed that the peptide binds to the two hydrophobic pockets. In the present study, we resolved the crystal structure of the complex between ALG-2 and a peptide of Sec31A (outer shell component of coat complex II, COPII; containing the type 2 motif) and found that the peptide binds to the third hydrophobic pocket (Pocket 3). While amino acid substitution of Phe⁸⁵, a Pocket 3 residue, with Ala abrogated the interaction with Sec31A, it did not affect the interaction with ALIX. On the other hand, amino acid substitution of Tyr¹⁸⁰, a Pocket 1 residue, with Ala caused loss of binding to ALIX, but maintained binding to Sec31A. We conclude that ALG-2 recognizes two types of motifs at different hydrophobic surfaces. Furthermore, based on the results of serial mutational analysis of the ALG-2-binding sites in Sec31A, the type 2 motif was newly defined.     

Control scheme for micro/macro/megacell-overlaying cellular systemincluding an LEO satellite system

A flexible radio resource management technique is proposed for multilayered cellular systems that consist of megacells using LEO satellites, and macrocell and microcell overlaid terrestrial cellular systems. In the proposed system, the radio spectra for microcell and macrocell terrestrial systems are adaptively and autonomously shared according to the traffic conditions of each microcell. Moreover, the radio resource for a satellite system is also dynamically shared by a temporarily unused satellite band. Computer simulation confirms that the proposed system can achieve high system capacity by reusing the radio resource allocated for the satellite band     

A framework for constructing databases for supervisory control systems

This paper presents a framework for constructing databases for supervisory control systems. The proposed framework utilizes a generation-based approach and object-oriented framework libraries. In this framework, a database is designed for the target system from a design template, and the software for the database system is generated from the database design. The generated database system includes a domain-specific object system and a diagram and plant data editor, which provides effective data input functions. © 1998 Scripta Technica, Electr Eng Jpn, 123(1): 32–42, 1998     

Effect of Support Materials on the Selective Methanation of CO over Ru Catalysts

Selective methanation of CO in the reformate gas (CO/CO₂/H₂/H₂O = 0.175/17.9/70.9/11.1) proceeded over Ru catalysts supported on metal oxides and zeolites. CO was selectively methanated at wide temperature ranges (200–275 °C) over Ru/γ-Al₂O₃, Ru/TiO₂ Ru/H-Y and Ru/H-beta catalysts. Higher Ru contents in Ru/γ-Al₂O₃ improved the selective CO methanation rate.     

Detection of hepatitis C virus RNA in the liver by in situ hybridization

To examine HCV infection histologically, we attempted non-radioactive in situ hybridization of HCV-RNA in the liver. We amplified cDNA probe (360 base pairs) by PCR using the primers deduced from the core region of the HCV genome. The probe was labelled with digoxigenin by PCR and used for in situ hybridization on paraformaldehyde-fixed frozen liver sections. The hybrids were visualized immunohistochemically with alkaline-phosphatase-conjugated anti-digoxigenin and alkaline-phosphatase substrates. HCV-RNA-cDNA hybrids were detected in 21 of 24 patients with positive serum HCV markers, whereas there were no positive signals in the liver of 12 cases without HCV infection. The signal intensity of HCV-RNA-cDNA hybrids was abolished after RNase treatment. Various other specificity experiments also verified specific hybridization of HCV-RNA-cDNA. HCV-RNA was visualized in liver cells and most of them were regarded as hepatocytes from their characteristic features. The infected hepatocytes were frequently associated with mononuclear cell infiltration. Hepatocytes positive for HCV-RNA were sometimes binuclear and distributed in various patterns among cases tested. The present in situ hybridization of HCV RNA is highly sensitive and specific and the results suggest the host immune response to HCV-infected cells.