Raman spectroscopy as process analytical tool in downstream processing of biotechnology

Downstream processing or product recovery plays a vital role in the development of bioprocesses. To improve the bioprocess efficiency, some unconventional methods are much required. The continuous manufacturing in downstream processing makes the Process Analytical Technologies (PATs) as an important tool. Monitoring and controlling bioprocess are an essential factor for the principles of PAT and quality by design. Spectroscopic methods can apply to monitor multiple analytes in real-time with less sample processing with significant advancements. Raman spectroscopy is an extensively used technique as an analytical and research tool owing to its modest process form, non-destructive, non-invasive optical molecular spectroscopic imaging with computer-based analysis. Generally, its application is essential for the analysis and characterization of biological samples, and it is easy to operate with minimal sample. The innovation on various types of enhanced Raman spectroscopy was designed to enhance the Raman analytical technique. Raman spectroscopy could couple with chemometrics to provide reliable alternative analysis method of downstream process analysis. Thus, this review aims to provide useful insight on the application of Raman spectroscopy for PAT in downstream processing of biotechnology and Raman data analysis in biological fields.     

CSTR+MBR+双膜法工艺在水泥窑协同处理垃圾项目中的工程应用

介绍了溧水天山垃圾协同处置项目中良浆的主要工程设计,采用“CSTR+MBR+双膜法”处理技术。处理规模为3600t/d。运行情况表明该组合工艺COD出水浓度<60 mg/L,BOD5出水浓度<10 mg/L、NH3-N出水浓度<10 mg/L,去除率达99%以上。出水水质达到了《GB/T 19923—2005城市污水再生利用工业用水水质》中敞开式循环冷却水系统补充水标准要求。     

气流中液化天然气液滴破碎数值模拟研究

基于流体体积法和k-ε湍流模型对液化天然气单液滴在气流中的变形破碎情况进行模拟研究.研究不同We对液滴形态和破碎模式的影响,分析液滴形态变化过程中速度、加速度和阻力系数随时间的变化趋势,并研究不同流场下液滴变形破碎情况.结果表明,不同的We下,液滴呈现出不同的破碎模式,液滴发生剪切破碎的临界We为80左右,同一We下不...     

火炮动态模拟试验机内弹道数值模拟

在介绍火炮动态模拟试验机工作原理的基础上，分析了模拟试验机的内弹道特点，利用经典内弹道学和系统动力学理论，建立了模拟试验机的内弹道理论计算模型，给出了实例，结果表明，计算结果与实测结果具有较好的一致性。     

AWG波分复用器的多频调制色散特性

通过对弯曲阵列波导的优化设计 ,讨论了阵列波导光栅 (AWG)作波分复用器传输多频线性调制信号时的色散特性 ,得到其传输功率与波长的关系。分析表明 :对于优化弯曲波导 ,脉冲展宽波长Δλ≤ 0 .5nm ,插入损耗为 6± 1dB     

3G移动数据业务商业运营模式初探

移动数据业务对3G运营商至关重要.运营商经营移动数据业务的基本原则是:自主建设基本应用平台,对于数据应用需要与应用/内容提供商合作提供,独立提供应用单一的数据业务,自主建设数据应用支撑系统.不同移动数据业务的商业运营模式不同,根据市场、业务、伙伴关系、运营商自身等因素,可以将移动数据业务的商业运营模式分为四种类型:直销型、主动型、认证型、转售型.移动运营商要针对每类商业模式,制定具体的游戏规则.     

IntServ与DiffServ在VoIP QoS中的应用分析

介绍了VoIP QoS技术,针对当前两大主流QoS模型IntServ和DiffServ,论述了各自的工作原理及其在VoIP应用中的特点,并通过分析两种模型各自的优缺点,对一种结合两者优势的VolP的QoS模型方案作了探讨。     

风洞模型表面压力分布三维显示技术

风洞模型表面压力分布三维图形显示系统采用VisualStudio软件开发。通过读取X格式的模型文件,设置模型表面压力孔分布点位置,导入试验中测量压力的原始数据,对数据范围进行颜色设置,并对模型表面压力进行图形绘制着色处理。该系统能够较好地展示出模型表面压力数据分布,使用人员能够直观观察出模型表面压力的大小。     

Solute Segregation to Grain Boundaries in Al: A First-Principles Evaluation

Solute-induced grain boundary(GB) strengthening is eff ective in improving the toughness and tensile strength of polycrystalline alloys. In this work, GB segregation behaviors of solute elements in Al alloys and their potential eff ects on GB binding have been systematically investigated from fi rst-principles energetics. The low-energy Σ3(111) and Σ11(113) are immune to vacancy segregation, while high-energy Al GBs, such as Σ13(320), Σ9(221), Σ5(210), and Σ5(310), can attract both vacancies and...     

装甲车辆齿轮箱故障诊断中的信息增强技术

利用时域平均技术完成对周期信号的提取，通过对信号的内插处理、解调分析、重新抽样和时域平均，完成对轴频信号和啮频信号的提取；通过对故障信号特点的研究，提出了故障信息增强方法，给出了故障敏感因子。通过对装甲车辆齿轮传动箱振动加速度信号测试结果分析，得到了良好的效果。与未采用故障信息增强方法相比，不仅提高了信号的信噪比，而且提高了故障信息。