Pharmacological studies of dopamine transporter imaging agent ~(125/131)I-β-CIT

1 INTRODUCTIONParldnson's diseases axe frequent1y Observed in old people. The postmotem studiesof the patients demonstrated the degeneration of dopndnergic neurons in the substaniaulgra, which leads to a reduction of neuronal projections to the striatum and conse-qUenly a siedcan reduction of the dOPtalne transporters (DAT) which was presy-naPticthe located in st.iatum.[11 In the patients with Alzhefor's diseases, the sndlarphenomenon can also be .b,....d.I1] Thus, the decrease of the…     

Critical Heat Flux (CHF) Correlations for Subcooled Water Flow Boiling at High Pressure and High Heat Flux

The subcooled water flow boiling is beneficial for removing the high heat flux from the divertor in the fusion reactor,for which an accurate critical heat flux(CHF)correlation is necessary.Up to now,there are many CHF correlations mentioned for subcooled water flow boiling in the open literatures.However,the CHF correlations’accuracies for the prediction of subcooled water flow boiling are not satisfactory at high heat flux and high pressure for reactor divertor.The present paper compiled 1356 CHF experimental data points from 15 independent open literatures and evaluated 10 existing CHF correlations in subcooled water flow boiling.From the evaluation,the W-2 CHF correlation performs best for the experimental CHF data in all existing critical heat flux correlations.However,the predicted mean absolute error(MAE)of the W-2 correlation is not very ideal for all database and the MAE of the W-2 correlation is from 30%to 50%for some database.In order to enhance the CHF prediction accuracy in subcooled water flow boiling at high heat flux and high pressure,the present paper developed a new CHF correlation.Compared with other existing CHF correlations,the new CHF correlation greatly enhances the prediction accuracy over a broad range of pressures and heat fluxes which are desired in the cooling of high heat flux devices,such as those in the fusion reactor divertor.The validation results show that the new correlation has a MAE of 10.05%and a root mean squared error(RMSE)of 16.61%,predicting 68.1%of the entire database within±10%and 81.5%within±15%.The MAE of the new CHF correlation is 7.4%less than that of the best existing one(W-2 correlation),further confirming its superior prediction accuracy and reliability.Besides,the new CHF correlation works well not only for a uniform power profile but also for a non-uniform power profile in subcooled water flow boiling at high pressure and high heat flux.     

基于多源信息的TM遥感图像计算机分类

本文以榆林市城区及其周边范围为实验区,以TM遥感图像的第一主成分纹理信息、归一化植被指数和MNF变换得到的四个波段为数据源,采用支持向量机方法进行分类,并与最大似然法分类和单纯利用光谱信息的基于SVM分类结果进行比较.试验结果表明,将纹理分析方法应用于图像分类中可区分光谱混淆的地类;和传统的分类方法相比,采用支持向量机技术.使用光谱与纹理特征结合的分类方法可以获得更高的分类精度.     

Inhibition of heterocyclic aromatic amine formation in fried ground beef patties by garlic and selected garlic-related sulfur compounds

The effects of garlic and selected organosulfur compounds (diallyl disulfide, dipropyl disulfide, diallyl sulfide, allyl methyl sulfide, allyl mercaptan, cysteine, and cystine) on the formation of heterocyclic aromatic amines (HAAs) in fried ground beef patties were evaluated. Minced garlic cloves (ca. 4.8 to 16.7%, wt/wt) or organosulfur compounds (0.67 mmol) were added directly to ground beef. Patties (100 g) were fried at 225 degrees C (surface temperature) for 10 min per side. Two patties were fried for each replication, and five replicates were analyzed for each treatment. For each replicate, four subsamples were analyzed (two unspiked subsamples for concentration and two spiked subsamples for the recovery of HAA standards). The volatile sulfur compounds significantly (P < 0.05) reduced concentrations of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by reductions of 46 to 81%, while average reductions of 35, 22, and 71%, were achieved with cystine, cysteine, and whole garlic, respectively. The volatile sulfur compounds reduced concentrations of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by 34 to 67%, while reductions of 25, 19, and 63% (P < 0.05) were achieved with cystine, cysteine, and whole garlic, respectively. These studies confirm that garlic and some organosulfur compounds have the potential to reduce HAA formation incooked beef patties.     

南通市大气PM2.5中元素特征及重金属健康风险评价

通过分析南通市颗粒物组分网采样得到的PM2.517种金属浓度结果进行分析,并对所检出的重金属存在的风险、人体暴露和潜在生态风险健康进行评价。结果表明南通市PM2.5中重金属浓度均处于中等水平,检出的有毒重金属仅有Ni。重金属主要来源于土壤风沙灰尘,有毒重金属主要来源于金属冶炼、燃煤、汽车排放等。南通市环境空气PM2.5中重金属不同途径暴露强度是：直接摄入>皮肤接触摄入>呼吸摄入。儿童的暴露量在各个途径均高于成人。重金属Si暴露量最强,应予以重视。     

An optimal online algorithm for halfplane intersection

The intersection of N halfplanes is a basic problem in computational geometry and computer graphics,The optimal offline algorithm for this problem runs in time O(N log N).In this paper,an optimal online algorithm which runs also in time O(N log N) for this problem is presented.The main idea of the algorithm is to give a new definition for the left side of a given line,to assign the order for the opoints of a convex polygon.and then to use binary search method in an ordered vertex set.The data structure used in the algorithm is no more complex than array.     

计算机辅助椭圆齿轮的实体造型

采用椭圆齿轮节曲线上齿形中心的曲率半径作为当量齿轮的分度圆半径,从而直接引用圆柱齿轮齿形的设计方法,建立椭圆齿轮齿廓的齿形方程.通过VC编程,输入齿数、模数、偏心率后,实现椭圆齿轮其余参数、齿廓坐标值的自动计算和轮廓图形显示,并输出Pro/E实体造型所需的.ibl文件.借助于Pro/E强大的实体造型功能,完成椭圆齿轮的实体造型.     

INTERNAL FRICTION OF GRAIN BOUNDARIES IN Fe-P AND Fe-P-La ALLOYS CONTAINING TRACE Cu

The grain boundary internal friction(GBIF)in Fe-P and Fe-P-La alloys containing traceCu has been studied.It is found that an addition of 0.584—0.722 wt-% La obviously reducesthe IF,shifts grain boundary peaks towards higher temperatures,and produces a small addi-tional peak at even higher temperature.The mechanism of GBIF is explained as the movementof defects of atomic size,namely point defects,at gram boundaries and/or their clusters un-der stress.     

Irregular Characteristics of Bond Interface Formation in Ultrasonic Wire Wedge Bonding

The mechanism of ultrasonic wire wedge bonding, one of the die/chip interconnection methods, was investigated based on the characteristics of the ultrasonic wire bonding joints. The Al-1%Si wire of 25 μm in diameter was bonded on Au/Ni/Cu pad and the joint cross-section was analyzed by scanning electron microscopy （SEM） and energy-dispersive X-ray spectroscopy （EDX）. The results indicated that it is irregular for the ultrasonic bond formation, non-welded at the centre but joining well at the periphery, especially at the heel and toe of the joint. Furthermore, the diffusion and/or reaction at the cross-section interface are not clear at C-zone, while there exists a strip layer microstructure at P-zone, and the composition is 78.96 at. pct Al and 14.88 at. pct Ni, close to the Al3Ni intermetallic compound. All these observations are tentatively ascribed to the plastic flow enhanced by ultrasonic vibration and repeated cold deformation driving interdiffusion between AI and Ni at bond interface.     

A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

The main goal of the present study was to evaluate the long-term effects of a perinatal palatable high-fat diet on the food intake and cholesterol profile of adult rats. Male Wistar rats (aged 22 days) were divided into two groups according to their mother’s diet during gestation and lactation (C _p, n = 10; pups from control mothers; and HL_p n = 10; pups from mothers fed a palatable high-fat diet). At the 76th day, pups were housed individually for 14 days, and daily food consumption was determined during a period of 6 days. Blood from 100-day-old rats was sampled by cardiac puncture. Fasting (12 h) serum glucose, total cholesterol, LDL-C, HDL-C, triglycerides (TG), and VLDL-C levels were determined. The measurement of food intake was higher in the animals submitted to a hyperlipidic diet during the perinatal period. Serum total cholesterol, LDL-C, HDL-C, TG, VLDL-C and glycemia were increased in the HL_p group compared to the control group. Our findings show that an early life environment with a high-fat diet can contribute to metabolic disease in later life.