Development and application of VPG simulation technique based on equivalent virtual road profile

A Virtual Proving Ground (VPG) is a vehicle simulation environment used for evaluating durability of the suspension elements. Among the components that comprise the VPG system, the tire model with its complex nonlinear characteristics has most significant impact on the credibility of the estimated durability. This research proposes a method for generating an equivalent road profile as a way to compensate for the limits involved in modeling details of the tire characteristics. The method first identifies the frequency response function from the road heights to the spindle forces, which would contain rich information on the tire’s effect on the vehicle dynamics. Then it back-calculates a road profile using this model and the spindle force measurement. Finally the solution is updated iteratively until it yields the spindle forces close to their measured values. Using the proposed method, an equivalent road profile was successfully generated from a spindle force measurement collected from a physical durability test. In order to investigate validity of the proposed method, durability analysis was performed for a suspension component — a lower control arm. From the preliminary VPG simulation results, it was confirmed that the estimated fatigue life agreed well with the estimation based upon the force measurement.     

Short-term synergistic effect of fruit extracts with red-ginseng on forced swimming endurance capacity in ICR mice

This study was designed to evaluate the effect of the oral administration of fruit extracts (lemon and Japanese apricot) combined with red-ginseng on the endurance and availability of metabolic substrates in ICR mice. Administration of the fruit extracts and red-ginseng (RG) (1:1) significantly increased swimming capacity, by 40%, with increased expenditures of non-esterified fatty acids and triglycerides in the plasma of the mice after 1 week of feeding. There was no significant increase in swimming capacity with the fruit extract alone. These results suggest that the fruit extract could synergistically elevate the effects of red-ginseng on swimming capacity in the mice by increasing fat utilization and reducing the consumption of stored glucose.     

Continuous-Wave Laser Patterning of Three-Dimensional Microstructure in Glasses Containing Silver Nanoparticles

A method is reported that uses visible continuous-wave laser to directly fabricate micropatterns in glasses containing silver (Ag) nanoparticles. Ag nanoparticles were formed in the glass using thermal treatment. Upon laser irradiation, Ag nanoparticles with their surface plasmon in resonance with the laser beam were partially melted and decreased in size due to the temperature increase induced by the excited Ag nanoparticles. Three-dimensional patterns were achieved by scanning the laser beam through the thickness of the glass.     

A Novel Two-Step Channel-Prediction Technique for Supporting Adaptive Transmission in OFDM/FDD System

This paper introduces a novel channel-prediction technique for an orthogonal frequency-division multiplexing (OFDM)/frequency-division duplex (FDD) system to support an adaptive-modulation and coding (AMC) scheme over a rapidly time-varying multipath fading channel. Most channel-prediction techniques assume that there is no channel variation in the predefined time duration, e.g. the slot. As a result, those techniques cannot compensate for the degradation of packet-error-rate (PER) performance, resulting from the rapid channel variation over the slot duration. In this paper, we propose a novel two-step channel-prediction technique that considers the time-varying nature of a channel over the duration of interest. Simulation results show that the AMC scheme of the OFDM/FDD system utilizing the proposed channel-prediction technique can guarantee the target PER of 1% without any loss of system throughput compared with a case supported by a conventional channel prediction under ITU-R Veh A 30 km/h.     

A Fast Computation Method in Frequency Domain for Power Ground Plane Impedance Calculation Using the Mobius Transform

A new method to reduce the computation time in power/ground-plane analysis is proposed. The proposed method is based on an approximation of impedance in the frequency domain using Mobius transform. The power/ground plane impedance is transformed by Mobius transform and is more linear than the raw impedance, which ensures that a simple approximation is possible. After the approximation, an inverse Mobius transform is applied to predict the power/ground plane impedance. This method displays the high speed of computing with good accuracy. In the case of impedance calculation for a 17.78 cm times 10.16 cm printed circuit board (PCB) board, the proposed method has shown to be 12 times faster than conventional methods. This method can be applied to the analysis and design of power/ground-plane where complex computation is needed.     

Neuronal cell protective and antioxidant effects of phenolics obtained from Zanthoxylum piperitum leaf using in vitro model system

In order to obtain basic data for the utilisation of Zanthoxylum piperitum leaf as a functional substance in the food industry, the antioxidative and neuronal cell protective effects of silica-gel open column chromatographic fractions, obtained from Z. piperitum leaf, were examined. ABTS and FRAP assays indicated that the ZP4 fraction (eluted with methanol/chloroform, 1:4, v/v) of Z. piperitum leaf was a more potent radical-scavenger and reducing agent than the other five fractions. The ZP4 fraction also presented protective effects against H₂O₂-induced neurotoxicity in a dose-dependent manner. Therefore, our study verified that the ZP4 fraction has strong antioxidative and neuronal protective effects which are correlated with its high level of phenolics, particularly quercitrin, afzelin, and hyperoside. These phenolics of Z. piperitum leaf can be utilised as effective and safe functional food substances, i.e., natural antioxidants, and may reduce the risk of neurodegenerative disorders.     

Cyclic Peptide Mimotopes for the Detection of Serum Anti–ATIC Autoantibody Biomarker in Hepato-Cellular Carcinoma

Tumor-associated (TA) autoantibodies have been identified at the early tumor stage before developing clinical symptoms, which holds hope for early cancer diagnosis. We identified a TA autoantibody from HBx-transgenic (HBx-tg) hepatocellular carcinoma (HCC) model mouse, characterized its target antigen, and examined its relationship to human HCC. The mimotopes corresponding to the antigenic epitope of TA autoantibody were screened from a random cyclic peptide library and used for the detection of serum TA autoantibody. The target antigen of the TA autoantibody was identified as an oncogenic bi-functional purine biosynthesis protein, ATIC. It was upregulated in liver cancer tissues of HBx-tg mouse as well as human HCC tissues. Over-expressed ATIC was also secreted extracellularly via the cancer-derived exosomes, which might cause auto-immune responses. The cyclic peptide mimotope with a high affinity to anti-ATIC autoantibody, CLPSWFHRC, distinguishes between serum samples from HCC patients and healthy subjects with 70.83% sensitivity, 90.68% specificity (AUC = 0.87). However, the recombinant human ATIC protein showed a low affinity to anti-ATIC autoantibody, which may be incompatible as a capture antigen for serum TA autoantibody. This study indicates that anti-ATIC autoantibody can be a potential HCC-associated serum biomarker and suggests that autoantibody biomarker’s efficiency can be improved by using antigenic mimicry to native antigens present in vivo.     

Evolution of the linkage structure of ICT industry and its role in the economic system: the case of Korea*

ABSTRACT

When assessing the structural role of an industry sector within an economic system, considering its relationship to other sectors is crucial. Among others, Information and Communication Technology (ICT) industry, one of the innovation accelerators or key engines of economic growth, is evaluated. Specifically, we analyze inter-industry production inducement linkages within a qualitative input–output analysis framework, since it is useful for understanding the key structure of an economic system. Our purpose is to understand the significant spillover structure of the Republic of Korea’s ICT industry within the national production system, as it has played an important role in the national economy and grown dramatically over the years. The findings from the structural analysis, focused on changes in links, are as follows: First, ICT manufacturing showed a higher degree of heterogeneity than ICT service sectors in its sensitivity effects structure, an indication that this sector needs to be utilized in various other industries. Second, the spectrum of industries having significant production inducement linkages with the ICT industry is limited and furthermore, the influence effects of the ICT manufacturing sector diminished considerably although the ICT industry’s sensitivity effects increased. Finally, intra-industry linkages within the ICT industry are gradually strengthened especially between ICT services and manufacturing. These findings call for sustained policy efforts to promote the virtuous circle in the overall inter-industry production inducement system, by increasing the utilization of products and services from other sectors by ICT sectors (especially ICT manufacturing) as well as the application of ICT in other sectors.     

Chiral Stereoisomer Engineering of Electron Transporting Materials for Efficient and Stable Perovskite Solar Cells

A series of chiral stereoisomers of electron transporting materials with two chiral substituents is rationally designed and synthesized, and the influence of stereoisomerism on their physical and electronic properties is investigated to demonstrate highly efficient and stable perovskite solar cells (PSCs). Compared to mesomeric naphthalene diimide (NDI) derivatives, which have heterochiral side groups with centrosymmetric molecular packing of symmetric‐shaped conformers in the crystalline state, enantiomeric NDI derivatives have homochiral side groups that exhibit non‐centrosymmetric molecular packing of asymmetric‐shaped conformers in the crystalline state and exhibit better solution processability based on one order of magnitude higher solubility. A similar trend is observed in different rylene diimide stereoisomers based on larger semiconducting core perylene diimide. The PSCs based on NDI enantiomers with good film‐forming ability and a very high lowest phase transition temperature (T_lowest) of 321 °C exhibit a high and uniform average power conversion efficiency (PCE) of 19.067 ± 0.654%. These PSCs also have a high temporal device stability, with less than 10% degradation of the PCE at 100 °C for 1000 h without encapsulation. Therefore, chiral stereoisomer engineering of charge transporting materials is a potential approach to achieve high solution processability, excellent performance, and significant temporal stability in organic electronic devices.