Signal and noise theory for a dc SQUID amplifier

A theory is presented for the gain and noise in an amplifier based on a dc SQUID. In the lumped circuit approximation, the total inductance of the input circuitL _T is coupled to the SQUID inductanceL via a mutual inductanceM _ii = _e (LL _T )^1/2 and is in series with a voltage source with a resistanceR _i and a capacitanceC _i . The results are expressed in terms of parameters for a SQUID with reduced inductance (1– _e ² )L. The voltage gain of the amplifier at frequency /2 isM _i V ^r /Z _T ^* (), while the total voltage noise at the output of the SQUID isV _N ^r ()+M _i ² V ^r J _N ^r () (R _i + 1/jC _i )/L _TZ _T ^* (). Here,Z _T ^* ()=Z _T ()–J ^r M _i ² (R _i + 1/jC _i )/L _i , whereZ _T () is the total impedance of the unloaded input circuit,V ^r andJ ^r are the flux-to-voltage and flux-to-circulating current transfer functions of the reduced SQUID, andV _N ^r () andJ _N ^r () are the noise voltage and noise current of the reduced SQUID.     

Frequency multiplexed superconducting quantum interference device readout of large bolometer arrays for cosmic microwave background measurements

A technological milestone for experiments employing transition edge sensor bolometers operating at sub-Kelvin temperature is the deployment of detector arrays with 100s-1000s of bolometers. One key technology for such arrays is readout multiplexing: the ability to read out many sensors simultaneously on the same set of wires. This paper describes a frequency-domain multiplexed readout system which has been developed for and deployed on the APEX-SZ and South Pole Telescope millimeter wavelength receivers. In this system, the detector array is divided into modules of seven detectors, and each bolometer within the module is biased with a unique ～MHz sinusoidal carrier such that the individual bolometer signals are well separated in frequency space. The currents from all bolometers in a module are summed together and pre-amplified with superconducting quantum interference devices operating at 4 K. Room temperature electronics demodulate the carriers to recover the bolometer signals, which are digitized separately and stored to disk. This readout system contributes little noise relative to the detectors themselves, is remarkably insensitive to unwanted microphonic excitations, and provides a technology pathway to multiplexing larger numbers of sensors.     

Optimization of dc SQUID voltmeter and magnetometer circuits

We calculate the signal-to-noise ratio in a dc SQUID system as a function of source impedance, taking into account the effects of current and voltage noise sources in the SQUID. The optimization of both tuned and untuned voltmeters and magnetometers is discussed and typical sensitivities are predicted using calculated noise spectra. The calculations are based on an ideal symmetric dc SQUID with % MathType!MTEF!2!1!+-% feaafeart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4baFfea0dXde9vqpa0lb9% cq0dXdb9IqFHe9FjuP0-iq0dXdbba9pe0lb9hs0dXda91qaq-xfr-x% fj-hmeGabaqaciGacaGaaeqabaWaaeaaeaaakeaacqaHYoGycqGH9a% qpcaaIYaacbaGaa8htaiaa-LeadaWgaaWcbaacbiGaa4hmaaqabaGc% caGGVaGaeuOPdy0aaSbaaSqaaiaa+bdaaeqaaOGaeyypa0JaaGymaa% aa!3D23!\[\beta = 2LI_0 /\Phi _0 = 1\] and moderate noise rounding % MathType!MTEF!2!1!+-% feaafeart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4baFfea0dXde9vqpa0lb9% cq0dXdb9IqFHe9FjuP0-iq0dXdbba9pe0lb9hs0dXda91qaq-xfr-x% fj-hmeGabaqaciGacaGaaeqabaWaaeaaeaaakeaaiiGacqWFOaakcq% WFtoWrcqWF9aqpcqWFYaGmcqaHapaCcaWGRbWaaSbaaSqaaiaadkea% aeqaaGqaaOGaa4hvaiaac+cacaGFjbWaaSbaaSqaaerbbjxAHXgaiu% GacaqFWaaabeaakiab-z6agnaaBaaaleaacaqGGaacbiGaaWhmaaqa% baGccqGH9aqpcaaIWaGaaiOlaiaaicdacaaI1aGaaiykaaaa!471A!\[(\Gamma = 2\pi k_B T/I_0 \Phi _{{\rm{ }}0} = 0.05)\], where ₀ is the flux quantum, T is the temperature, L is the SQUID inductance, and I ₀ is the critical current of each junction. The optimum noise temperatures of tuned and untuned voltmeters are found to be 2.8(L/R)T and 8(L/R)T (1 + 1.5² + 0.7⁴)^1/2/² respectively, where /2 is the signal frequency, assumed to be much less than the Josephson frequency, and is the coupling coefficient between the SQUID and its input coil. It is found that tuned and untuned magnetometers can be characterized by optimum effective signal energies given by (16k _B TLE/² R)[1 + (1 + 1.5² + 0.7²)^1/2 + 0.75²] and 2k_B T _iR_iB/² L _p respectively, where B is the bandwidth, R _i is the resistance representing the losses in the tuned circuit at temperature T _i and L _p is the inductance of the pickup coil.This work was supported by the Division of Materials Sciences, Office of Basic Energy Sciences, U.S. Department of Energy, and by the U.S. Office of Naval Research.Guggenheim Fellow.     

Very low-noise ENG amplifier system using CMOS technology.

In this paper, we describe the design and testing of a system for recording electroneurographic signals (ENG) from a multielectrode nerve cuff (MEC). This device, which is an extension of the conventional nerve signal recording cuff, enables ENG to be classified by action potential velocity. In addition to electrical measurements, we provide preliminary in vitro data obtained from frogs that demonstrate the validity of the technique for the first time. Since typical ENG signals are extremely small, on the order of 1 1 microV, very low-noise, high-gain amplifiers are required. The ten-channel system we describe was realized in a 0.8 microm CMOS technology and detailed measured results are presented. The overall gain is 10 000 and the total input-referred root mean square (rms) noise in a bandwidth 1 Hz-5 kHZ is 291 nV. The active area is 12 mm(2) and the power consumption is 24 mW from +/-2.5 V power supplies.     

Radio frequency identification (RFID) performance: the effect of tag orientation and package contents

The objective of this research was to determine the relationship between different product types and tag orientations on the readability of RFID tags on shipping containers in a palletload that is driven through a portal type reader. This research finds that the content of packages can dramatically reduce the read rate. Only 25% of the tags on shipping containers containing water‐filled bottles could be read. Rice‐filled jars had a higher read rate (80.6%). Even empty boxes did not have a 100% read rate. For the variables without appreciable package contents, only 74–79% of loads had all of their tags read. The orientation of the tag does make a difference, especially when coupled with a filled package between it and the reader antennae. Tags facing outwards, towards the reader antennae, had the highest likelihood of a successful read. When tags for the boxes of water‐filled bottles were all facing downwards, no tags were read. Supply chain managers need to understand these limitations of the technology and find ways to overcome them before RFID can be successfully implemented in supply chains. Copyright © 2005 John Wiley & Sons, Ltd.     

21世纪初ICRP建议书草案

在过去的几年中，国际放射防护委员会鼓励对其计划将于2005年发表的下一个建议书表述辐射防护理念的最佳方式开展讨论。现在的建议书是由1990年发表的第60号出版物提出的，而且得到过去12年里发表的其它出版物的补充。现在显然委员会有必要总结在大约10个报告中推荐的数值数量的完整性。本文将完成这项工作，并由此而表明前进方向，提出一个简明且比较一致的21世纪初防护理念的表述。当然并不意在进行根本的修改，而是建议对现行政策做出连贯一致的表述，对其应用进行简化。     

Automated Compositional Abstraction Refinement for Concurrent C Programs: A Two-Level Approach

The state space explosion problem in model checking remains the chief obstacle to the practical verification of real-world distributed systems. We attempt to address this problem in the context of verifying concurrent (message-passing) C programs against safety specifications. More specifically, we present a fully automated compositional framework which combines two orthogonal abstraction techniques (operating respectively on data and events) within a counterexample-guided abstraction refinement (CEGAR) scheme. In this way, our algorithm incrementally increases the granularity of the abstractions until the specification is either established or refuted. Our explicit use of compositionality delays the onset of state space explosion for as long as possible. To our knowledge, this is the first compositional use of CEGAR in the context of model checking concurrent C programs. We describe our approach in detail, and report on some very encouraging preliminary experimental results obtained with our tool MAGIC.     

Quality of Service Networking for High Performance Grid Applications

This paper reports on different efforts to provide quality of service (QoS) Networking to Grid applications done in the context of the MB-NG, GRS and DataTAG EU projects. These are leading edge network research projects involving more that 50 researchers in the UK, Europe and North America, concerned with the development and testing of protocols and standards for the next generation of high speed networks. We have implemented and tested the Differentiated Services Architecture (DiffServ) in a multi-domain, 2.5 Gbits/s network (the first such deployment) defining appropriate Service Level Agreements (SLAs) to be used between administrative domains to guarantee end-to-end Quality of Service. We characterised several hardware implementations of DiffServ and concluded on their appropriateness for several network scenarios. Since current and future Grid applications will have to use modified mechanisms of congestion control we have evaluated old and new TCP implementations over a Differentiated Services Networks. These quality of service tests have also included innovative MPLS (Multi-Protocol Label Switching) experiments to establish guaranteed bandwidth connections to Grid applications in a fast and efficient way. We have also developed a software based bandwidth broker architecture for Grids based on IETF standards which allows applications to transparently request dynamic and advanced reservations and implemented it in a real experimental network. We finally report on experiences delivering Quality of Service networking to high performance applications like Particle Physics data transfer and High Performance Computation. This includes quantitative results on the performance improvements that QoS brought to real data transfers in the context of High Performance Computing.     

Retailers' tagging practices: a potential liability?

This study investigates the coverage of federally mandated information on over‐the‐counter (OTC) drug labels by electronic article surveillance (EAS) tags applied to the exterior of cartons. Using adult‐strength analgesics containing acetaminophen as a case study, researchers investigated the issue in Houston, Texas (24 stores) and Lansing, Michigan (33 stores). The information obscured by EAS tags was identified and classified for a total of 849 packages using a standardized data collection instrument. The results indicated that 293 packages examined, or 34.5%, had information mandated by the US Food and Drug Administration (US FDA) fully or partially obscured by the EAS tags. Retailers and manufacturers should be aware of such practices to reduce potential liability. Recommendations for improving EAS tag usage on OTC products are presented. Copyright © 2004 John Wiley & Sons, Ltd.     

Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer

Endocrine therapy, targeting the oestrogen receptor pathway, is the most common treatment for oestrogen receptor-positive breast cancers. Unfortunately, these tumours frequently develop resistance to endocrine therapies. Among the strategies to treat resistant tumours are sequential treatment (in which second-line drugs are used to gain additional responses) and intermittent treatment (in which a ‘drug holiday’ is imposed between treatments). To gain a more rigorous understanding of the mechanisms underlying these strategies, we present a mathematical model that captures the transitions among three different, experimentally observed, oestrogen-sensitivity phenotypes in breast cancer (sensitive, hypersensitive and independent). To provide a global view of the transitions between these phenotypes, we compute the potential landscape associated with the model. We show how this oestrogen response landscape can be reshaped by population selection, which is a crucial force in promoting acquired resistance. Techniques from statistical physics are used to create a population-level state-transition model from the cellular-level model. We then illustrate how this population-level model can be used to analyse and optimize sequential and intermittent oestrogen-deprivation protocols for breast cancer. The approach used in this study is general and can also be applied to investigate treatment strategies for other types of cancer.