Highly efficient cryogenically-cooled Yb:YAG laser

A MOPA laser system for high pulse energy and high average power has been developed by using a cryogenic Yb:YAG. In the regenerative amplifier with our original TRAM architecture, the high pulse energies of 6.5 and 1.5 mJ were obtained at the repetition rate of 200 Hz and 1 kHz, respectively. An optical efficiency was as high as η_o-o = 9.3% with an excellent beam quality of M ² < 1.1, which ensured that a cryogenic Yb:YAG TRAM had a high thermal strength. The following four pass power amplifier with a cryogenic Yb:YAG rod showed 140 mJ at 100 Hz. Both a high optical efficiency of η_o-o = 30% and a high slope efficiency of η_s = 44% showed that an efficient laser operation could be realized for a power amplification with both a high pulse energy and a high average power by using a cryogenic Yb:YAG.     

Intrinsic self‐initiating thermal ring‐opening polymerization of 1,3‐benzoxazines without the influence of impurities using very high purity crystals

A phenol/aniline type monofunctional benzoxazine monomer, PH‐a , is synthesized and highly purified to study the intrinsic thermal ring‐opening polymerization of benzoxazines without the influence of any impurity. The successful synthesis of the monomer and its corresponding chemical structure are confirmed by Fourier transform infrared spectroscopy (FTIR) and ¹H nuclear magnetic resonance (¹H NMR) spectroscopy. Purity of the compound is evaluated through differential scanning calorimetry (DSC) as well as elemental analysis (EA). Moreover, the thermal behavior of benzoxazine monomer toward polymerization is also studied by DSC, indicating that the highly purified benzoxazine monomer actually polymerize upon heating. The results present evidence of an intrinsic tendency for 1,3‐benzoxazines to undergo thermally induced ring‐opening polymerization upon heating only without any impurity participating during the reaction. This reveals that polybenzoxazines can be obtained by both the traditional thermally accelerated (or activated) polymerization, where impurities or purposefully added initiators are involved in the reaction; or, by the classic thermal polymerization, where only heat is enough to initiate the reaction. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55, 3434–3445     

Total synthesis of ecteinascidin 743

The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation.     

Total synthesis of polyamine toxin HO-416b and Agel-489 using a 2-nitrobenzenesulfonamide strategy

Total synthesis of spider toxins HO-416b (1) and Agel-489 (2) was accomplished using the 2-nitrobenzenesulfonamide (Ns) group as both a protecting and activating group. In this strategy, the C-N bonds were constructed by alkylation of sulfonamides with alkyl halides or Mitsunobu reaction with the corresponding alcohol. Beginning with monoprotection of the symmetrical diamine, the construction of the backbone from diamine 3 was efficiently accomplished in 7 steps for 14 and 9 steps for 29. Removal of the Ns group while the substrate was attached to a novel solid support enabled the efficient isolation of this highly polar compound.     

Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by P and H NMR metabolic images under A 2-T magnetic field

The relationships among tissue edema, lactate accumulation, and intracellular pH in middle cerebral artery (MCA)-occluded rats were investigated with multiecho ¹H magnetic resonance imaging and spatially resolved metabolic images constructed by ¹H and ³¹P nuclear magnetic resonance (NMR) chemical shift imaging (CSI). For the effective and sensitive detection of NMR signals from the brain, outer volume suppression (OVS), reduced k-space sampling and proton irradiation were incorporated into the CSI sequences. The consecutive three measurements of calculated T₂ image, lactate image, and pH image which were required for 3.75 h were repeated for four cycles of 1–16 h after MCA occlusion. Tissue edema and lactate accumulation in the infarcted region were gradually and consistently increased during the 15-h observation period. In contrast, severe acidosis was already detected on the first pH image (2–4.7 h after MCA occlusion); thereafter, the degree of acidosis became milder and showed no further progression. The dissociation between the time courses of the lactate accumulation and pH decrease was clearly demonstrated by the NMR metabolic images. Acid-base balance in cerebral infarction might be affected not only by lactate production but also by complicated interactions with tissue edema and some other factors.     

紧拓扑半群上概率测度卷积序列的极限性质

本文讨论紧拓扑半群上概率测度卷积序列的若干重要极限性质．在第１节中，我们讨论测度集的代数结构与其支撑集代数结构的关系．第２节的定理１，通过支撑集的代数结构给出组合收敛测度序列的一个极限定理．在定理２中我们讨论独立同分布时的情形，建立了一类紧半群上的Ｋａｗａｄａ－Ｉｔ型结果．这些定理推广了紧群、紧交换半群、紧Ｌ－Ｘ半群上一些相应的结论．     

透射式GaAs光电阴极的X射线衍射研究

本文介绍了高精度多晶多反射X射线衍射仪的一种新的应用.首次将其应用于研究高灵敏度第三代微光象增强器中由掺Zn的p型GaAs/GaAlAs、玻璃组成的光电阴极的材料特性；发展了用倒格子空间衍射图方法评价光电阴级组件晶体质量的方法.通过分析得知,衍射强度在倒格子空间沿。方向展宽主要起因于晶体中的嵌镶效应的增强.文中采用衍射动力学理论的计算方法并忽略初始条件,模拟后得到的曲线与衍射强度沿ω/θ方向的投影强度曲线符合的比较好.粘接良好的阴极样品表明,GaAs/GaAlAs晶格常数的变化基本上可以消除,但粘接引起的嵌镶效应的增强却不能完全消除.