Simultaneous Determination of Caffeine and Paracetamol in Commercial Formulations Using Greener Normal-Phase and Reversed-Phase HPTLC Methods: A Contrast of Validation Parameters

There has been no assessment of the greenness of the described analytical techniques for the simultaneous determination (SMD) of caffeine and paracetamol. As a result, in comparison to the greener normal-phase high-performance thin-layer chromatography (HPTLC) technique, this research was conducted to develop a rapid, sensitive, and greener reversed-phase HPTLC approach for the SMD of caffeine and paracetamol in commercial formulations. The greenness of both techniques was calculated using the AGREE method. For the SMD of caffeine and paracetamol, the greener normal-phase and reversed-phase HPTLC methods were linear in the 50–500 ng/band and 25–800 ng/band ranges, respectively. For the SMD of caffeine and paracetamol, the greener reversed-phase HPTLC approach was more sensitive, accurate, precise, and robust than the greener normal-phase HPTLC technique. For the SMD of caffeine paracetamol in commercial PANEXT and SAFEXT tablets, the greener reversed-phase HPTLC technique was superior to the greener normal-phase HPTLC approach. The AGREE scores for the greener normal-phase and reversed-phase HPTLC approaches were estimated as 0.81 and 0.83, respectively, indicated excellent greenness profiles for both analytical approaches. The greener reversed-phase HPTLC approach is judged superior to the greener normal-phase HPTLC approach based on numerous validation parameters and pharmaceutical assays.     

An Integrated Fuzzy Analytic Hierarchy Process (AHP) Model for Studying Significant Factors Associated with Frequent Lane Changing

Frequent lane changes cause serious traffic safety concerns, which involve fatalities and serious injuries. This phenomenon is affected by several significant factors related to road safety. The detection and classification of significant factors affecting lane changing could help reduce frequent lane changing risk. The principal objective of this research is to estimate and prioritize the nominated crucial criteria and sub-criteria based on participants’ answers on a designated questionnaire survey. In doing so, this paper constructs a hierarchical lane-change model based on the concept of the analytic hierarchy process (AHP) with two levels of the most concerning attributes. Accordingly, the fuzzy analytic hierarchy process (FAHP) procedure was applied utilizing fuzzy scale to evaluate precisely the most influential factors affecting lane changing, which will decrease uncertainty in the evaluation process. Based on the final measured weights for level 1, FAHP model estimation results revealed that the most influential variable affecting lane-changing is ‘traffic characteristics’. In contrast, compared to other specified factors, ‘light conditions’ was found to be the least critical factor related to driver lane-change maneuvers. For level 2, the FAHP model results showed ‘traffic volume’ as the most critical factor influencing the lane changes operations, followed by ‘speed’. The objectivity of the model was supported by sensitivity analyses that examined a range for weights’ values and those corresponding to alternative values. Based on the evaluated results, stakeholders can determine strategic policy by considering and placing more emphasis on the highlighted risk factors associated with lane changing to improve road safety. In conclusion, the finding provides the usefulness of the fuzzy analytic hierarchy process to review lane-changing risks for road safety.     

Simultaneous electron-photon excitation of hydrogen and helium

Total and differential cross sections for simultaneous excitation of H(2s), H(3s) and He(1s 2s) by electron impact in the presence of a photon field have been calculated in second-order perturbation theory. The characteristics of the results are interpreted in terms of their physical origin. The off-shell excitation cross section for the He(1s 2s) state is found to be one order of magnitude smaller than that for excitation of the H(2s) state. This is consistent with our expection that atoms with higher dipole-polarisability should favour larger off-shell cross sections for transitions betweens-states.     

Analysis and finite element approximation of a Ladyzhenskaya model for viscous flow in streamfunction form

In this paper we consider a model for the motion of incompressible viscous flows proposed by Ladyzhenskaya. The Ladyzhenskaya model is written in terms of the velocity and pressure while the studied model is written in terms of the streamfunction only. We derived the streamfunction equation of the Ladyzhenskaya model and present a weak formulation and show that this formulation is equivalent to the velocity–pressure formulation. We also present some existence and uniqueness results for the model. Finite element approximation procedures are presented. The discrete problem is proposed to be well posed and stable. Some error estimates are derived. We consider the 2D driven cavity flow problem and provide graphs which illustrate differences between the approximation procedure presented here and the approximation for the streamfunction form of the Navier–Stokes equations. Streamfunction contours are also displayed showing the main features of the flow.     

The structure of a metallic glass system using EXELFS and EXAFS as complementary probes

The short-range atomic order around all three constituent atoms in a prototypical bulk metallic glass (BMG) system was probed in a complementary way, using extended X-ray absorption fine structure for neighborhood of the higher atomic number elements, and extended energy loss fine structure (EXELFS) for the lower atomic number ones. The Pd_xNi_(80−x)P₍₂₀₎ system is a prototype for a whole class of BMG formers which are 80% transition metal and 20% metalloid. We find that the structure of these BMGs could be explained in terms of those of glasses at the end of the BMG range, namely, Pd₆₀Ni₂₀P₂₀ and Pd₃₀Ni₅₀P₂₀. The binary phosphide crystals near x=0 and 80 are found to be simulate very well the local atomic structure of Pd₃₀Ni₅₀P₂₀ and Pd₆₀Ni₂₀P₂₀ glasses, respectively. The best glass former in this series, Pd₄₀Ni₄₀P₂₀, is best described by a weighted average of Pd₃₀Ni₅₀P₂₀ and Pd₆₀Ni₂₀P₂₀ structures.     

Interpretation of momentum distribution of recoil ions from laser induced nonsequential double ionization

We show that the recently reported momentum distribution of recoil ions from laser induced nonsequential double ionization can be interpreted as a combined effect of interelectron correlation and final state field interaction ("Volkov dressing") of the two outgoing electrons. We also find a cutoff formula for the recoil momentum that gives the maximum momenta observed in the experiments.     

Exact solution of the AF coherent pulse propagation equations

The exact solution of the adiabatic following pulse propagation equations describing coherent propagation of a single-photon quasi-resonant short pulse of arbitrary shape and phase is reported.     

S-matrix analysis of coincident measurement of two-electron energy distribution for double ionization of He in an intense laser field

Analyses of two mechanisms of double ionization of He in an intense femtosecond laser pulse are made within the S-matrix theory. Their contributions are compared with each other and with the recent data of coincidence measurements for two-electron energy distributions. It is found that the correlated energy-sharing mechanism reproduces the data remarkably well and also confirms the so-called "excessive production" of hot electrons in the process. In contrast, the shakeoff mechanism is found to fail completely to account for either the strength or the trend of the data and is therefore ruled out.     

NHC–Silver(I) Complexes as Chemical Nucleases; Synthesis,Crystal Structures,and Antibacterial Studies

A series of N‐heterocyclic carbene (NHC) precursors, 1‐methoxylethyl‐3‐allylimidazolium hexafluorophosphate ( 1 ), 1‐ethyl‐3‐allylimidazolium hexafluorophosphate ( 2 ), and 1‐pentyl‐3‐allylimidazolium hexafluorophosphate ( 3 ) were synthesized. These salts were treated with Ag₂O to afford their corresponding mononuclear Ag(I)‐NHC complexes, namely 1‐methoxylethyl‐3‐allylimidazolium silver(I) hexafluorophosphate ( 4 ), 1‐ethyl‐3‐allylimidazolium silver(I) hexafluorophosphate ( 5 ), and 1‐pentyl‐3‐allylimidazolium silver(I) hexafluorophosphate ( 6 ), respectively. These compounds were characterized by physicochemical and spectroscopy techniques. Compounds 4 and 5 were structurally characterized by single crystal X‐ray diffraction, and their stability in solution was investigated and found to be acceptable for the antibacterial studies. These new NHC precursors and their respective Ag–NHC complexes were screened for their antibacterial activities against Staphylococcus aureus (ATCC 12600) and Escherichia coli (ATCC 25922). Compounds 1–3 showed no inhibition, whereas 4–6 inhibited the growth of these bacteria. The nuclease activities of the reported compounds against plasmid DNA and RNA were assessed by gel electrophoresis, and the results indicate that complexes 5 and 6 can degrade both DNA and RNA in the absence of an oxidant.     

A Facile and Rapid Method for Preparation of Thiazine and Thiadiazine Derivatives by Sonication Technique

Ultrasound accelerated synthesis of 2,3-(substituted)benzo-1,4-thiazino[5,6-b]-4H-9H-7- methyl-10-oxoquinolines (4), 7-substituted-2,2-dimethyl-2,3-dihydro-1H,10H-phenothiazin- 4-one (5), 4-substituted-3,9, 10-trihydro-11-oxo-quinolino[2,3-b]-1,3,4-thiadiazino[2,3-d]- 1,2,4-triazole (6), and 7,7-dimethyl-7,8-dihydro-3H,5H,6H-1,2,4-triazolo[3,4-b][1,3,4] benzothiadiazin-9-one (7) from carbostyril and dimedone using sulfur powder and iodine as a catalyst in THF is reported. The structures of the compounds have been elucidated on the basis of spectral and elemental analysis.