风湿性关节炎动物模型中血啉甲醚荧光强度的同步检测研究

光动力疗法的疗效依赖于治疗过程中靶组织中光敏剂的含量或浓度 ,而药物在组织中的分布特性是受动物机体调控的 ,因此 ,同一个体不同组织对光敏剂吸收的时间特性需要同时进行检测才能排除个体之间的差异。建立了一套空间三通道激光诱导荧光同步检测装置 ,并用该装置研究了活体大耳白兔风湿性关节炎模型滑膜、软骨和皮肤对血啉甲醚吸收的时间特性。研究结果表明 ,炎性滑膜组织对血啉甲醚的吸收量远大于软骨和皮肤 ,这一差别在静脉给药即刻就很明显 ,在静脉给药后 2 0min内 ,滑膜中的光敏剂药物含量约为软骨和皮肤中的 6倍。因此 ,对于借助血啉甲醚 ,用光动力疗法治疗风湿性关节炎并采用体外照射治疗方案时 ,从注药即刻开始 ,前 2 0min左右进行光照治疗可能是较好的选择。     

The correlation of the energy resolution of incident light with the measured reflectance of multilayers

This paper presents an expression for describing the correlation of the energy resolution of incident light with the measured reflectance of multilayers, and gives a new method for calculating the polychromatic-light reflectance of multilayers. Using this method we give the reflectance spectrum of some multilayers in the case in which the incident light is polychromatic. The theoretical analysis shows that for the multilayers of a given design the peak reflectance of the polychromatic light is smaller than that of the monochromatic light, but no-peak reflectance of the polychromatic light is bigger than that of the monochromatic light. Further, the measured reflectance spectrum will be a line if the energy resolution is less than a decided value. The shorter the design-wavelength of the multilayer, the stronger the effect of the energy resolution on the reflectance.     

Effect of gas atoms on X-ray optical properties of multilayers

Multilayers always dissolve some gas atoms during sputtering. In this paper, we develop a new method to study the effect of gas atoms on X-ray reflectance of the multilayer. Our theoretical analysis shows that this effect depends not only on the content of gas atom but also on the wavelength and the grazing angle. The shorter the wavelength and the bigger the grazing angle, the stronger this effect of gas atoms. We fabricated Mo/Si multilayers under various sputtering pressures and measured their small angle X-ray diffraction spectra. The measured results coincide with those calculated by our method.