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81.
Masataka Deie Yoshio Sumen Nobuo Adachi Atsuo Nakamae Ayato Miyamoto Atsushi Kanaya Mitsuo Ochi 《Knee surgery, sports traumatology, arthroscopy》2007,15(1):61-66
The purpose of this study was to examine the long-term clinical results of meniscus transplantation for articular cartilage
defects in the knee joint. The type of study was case series. From October 1990 to June 1995, eight cases underwent allogenic
or autogenic meniscus transplantations for articular cartilage defects, and seven cases were available for follow-up evaluations.
The age at surgery ranged from 14 to 42 years of age (average 22.5). In one case, transplantation of tissue-engineered cartilage
was performed due to pain 5 years after surgery. The other six cases were followed up for 8–13 years (average 10.1). The size
of the cartilage defect ranged from 1.0 to 6.3 cm2 (average 2.8 cm2). Patients were evaluated with the Lysholm score and MR images. We also performed arthroscopic examinations in three cases
at the final evaluation. This study leads to the conclusion that meniscus transplantation for articular cartilage damage is
not comparable to autologous chondrocyte transplantation. Two cases showed a good clinical outcome but the tissue remained
as fibrocartilage tissue in the long-term. 相似文献
82.
Serial in vivo MR tracking of magnetically labeled neural spheres transplanted in chronic EAE mice. 总被引:5,自引:0,他引:5
Tamir Ben-Hur Ruud B van Heeswijk Ofira Einstein Michal Aharonowiz Rong Xue Emma E Frost Susumu Mori Benjamin E Reubinoff Jeff W M Bulte 《Magnetic resonance in medicine》2007,57(1):164-171
Neural stem cell (NSC) transplantation has been shown to attenuate the severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Central to the future success of NSC transplantation in MS is the ability of transplanted cells to migrate from the site of transplantation to relevant foci of disease. Using magnetically labeled mouse neurospheres and human embryonic stem cell (hESC)-derived neurospheres, we applied serial magnetic resonance imaging (MRI) to assess the biodynamics of transplanted cell migration in a chronic mouse EAE model. Magnetic labeling did not affect the in vitro and in vivo characteristics of cells as multipotential precursors. Cell migration occurred along white matter (WM) tracts (especially the corpus callosum (CC), fimbria, and internal capsule), predominantly early in the acute phase of disease, and in an asymmetric manner. The distance of cell migration correlated well with clinical severity of disease and the number of microglia in the WM tracts, supporting the notion that inflammatory signals promote transplanted cell migration. This study shows for the first time that hESC-derived neural precursors also respond to tissue signals in an MS model, similarly to rodent cells. The results are directly relevant for designing and optimizing cell therapies for MS, and achieving a better understanding of in vivo cell dynamics and cell-tissue interactions. 相似文献
83.
Hiroaki Shiba Takeyuki Misawa Susumu Kobayashi Tokuyasu Yokota Kyonsu Son Katsuhiko Yanaga 《Journal of gastrointestinal surgery》2007,11(4):549-551
A 41-year-old Chinese woman was admitted to our hospital with epigastric pain. Computed tomography detected a heterogeneous
enhancement tumor fed by the left gastroepiploic artery in the left lower quadrant and cholelithiasis. Excision of the tumor
in the greater omentum and cholecystectomy were performed laparoscopically. Histological findings confirmed a diagnosis of
hemangiopericytoma with low-grade malignancy. To our knowledge, hemangiopericytoma of the greater omentum is very rare, and
only 12 cases were reported in English literature. We report a case of hemangiopericytoma arising in the greater omentum and
review the literature. 相似文献
84.
In order to investigate the comparative fates of nivalenol (NIV) and 4-acetyl derivative of NIV (fusarenon-X, FX) in mice, 3H-FX or 3H-NIV was given p.o. to mice. Radioactivity was excreted mainly via the urine in mice given 3H-FX, but mainly via the feces in mice given 3H-NIV. The plasma radioactivity reached a peak at 30 or 60 min after the administration of 3H-FX or 3H-NIV, respectively. The plasma peak level was 5 times higher, and the area under curve (AUC) was 10 times higher, in 3H-FX-administered than 3H-NIV-administered mice. These findings clearly demonstrate that FX is absorbed from the gastrointestinal tract more rapidly and efficiently than NIV. The HPLC profile of radioactivity of acetonitrile extracts of urine and feces indicated that FX is rapidly metabolized to NIV after being absorbed from the gastrointestinal tract. In vitro incubation of tissue homogenates with 3H-FX demonstrated that the liver and kidney are the organs responsible for the FX-to-NIV conversion. Thus this study demonstrated that the higher oral toxicity of FX than NIV that has been observed in mice and rats is due to the efficient absorption of FX than NIV from the gastrointestinal tract, followed by its rapid conversion to NIV by the liver and kidney. 相似文献
85.
K Hashida K Taniguchi H Miyakawa M Miyamoto S Oda N Honda 《Masui. The Japanese journal of anesthesiology》1990,39(12):1673-1677
This study evaluated the usefulness of midazolam in inducing a anesthetic state in 60 patients who underwent surgery under general anesthesia. The patients were divided into 3 groups; a geriatric group, a hepatic dysfunction group, and a control group (adults without complications). To induce sleep 0.15 mg.kg-1 or 0.2 mg.kg-1 of midazolam was administered intravenously to all three groups. After the administration of midazolam, the mean time for obtaining absence of response to calling name and absence of ciliary reflex were not significantly different in the three groups. The pulse rate and respiratory rate also did not change remarkably. But significant decreases were observed in the systolic blood pressure and tidal volume in all three groups. However, they were not significantly different among the three groups. These results indicate that midazolam is a useful drug for inducing anesthetic state in geriatric patients and patients with hepatic dysfunction. 相似文献
86.
A case of a rare anomaly of the common bile duct associated with an abnormal arrangement of the pancreaticobiliary ductal union 总被引:1,自引:0,他引:1
L E Loria K Yamamoto T Eto T Tomioka T Miyamoto N Mochinaga R Tsuchiya 《The Japanese journal of surgery》1988,18(6):718-724
A 39 year-old Japanese female patient with a duplication of the distal portion of the common bile duct is presented herein. Moreover, an abnormal arrangement of the pancreaticobiliary ductal union, congenital biliary dilatation and carcinoma of the gallbladder were all demonstrated by cholangiographic and endoscopical studies. The patient underwent radical surgery for advanced adenosquamous carcinoma of the gallbladder, and her postoperative course was satisfactory. A reflux of pancreatic juice into the bile duct was demonstrated, but it was eliminated and considered to be a contributory etiologic factor of the gallbladder carcinoma. 相似文献
87.
M Nasu H Fujiwara J Sono Y Okada S Miyamoto S Nishiuchi K Tatemichi T Shomura 《The Journal of cardiovascular surgery》1990,31(6):809-811
Annulo-aortic ectasia is an extremely rare complication of Gaucher's disease. We report successful surgery in a patient with Gaucher's disease complicated by annulo-aortic ectasia and aortic dissection. Cabrol's operation was accomplished without bleeding or sternal adaptation problems. 相似文献
88.
M Kohjiro J Miyake K Koga K Miyamoto T Fukutome 《Masui. The Japanese journal of anesthesiology》1990,39(12):1664-1668
A new benzodiazepine-type drug, midazolam, was administered intramuscularly as a premedicant to 155 patients aged from 16 to 81 years with ASA status 1 or 2. The hypnotic action and the effect on the upper airway tract of midazolam were evaluated. Hypnosis appeared 5 minutes after the administration of midazolam, reached its plateau after 20 minutes and started to decline after 30 minutes. The hypnotic effect showed dose-dependent increase in doses ranging from 0.05 to 0.20 mg.kg-1. No age-dependent differences in hypnosis were observed except for teenage group which showed stronger hypnosis than the other age groups. There was no problem on the upper airway tract for all age groups at the dosage of 0.05 mg.kg-1, but in the patients over 40 years increasing dosage tended to obstruct the upper airway tract. Along with the appearance of hypnosis, cough and breath holding, suggesting retention and aspiration of saliva, were observed. The appropriate dosage of midazolam for premedication was considered to be 0.05 mg.kg-1. 相似文献
89.
Yoshimi Otani Ichiro Yoshida Satoshi Ohki Motoi Kano Osamu Kawashima Masao Suzuki Yasushi Sato Toru Takahashi Akio Ohtaki Susumu Ishikawa Yasuo Morishita 《Surgery today》1997,27(9):812-815
Pulmonary aspergillosis associated with old tuberculosis is generally resistant to treatment. Thus, if patients are treated
only with conservative therapy, their condition continues to deteriorate due to repetitive hemoptysis, and may even become
critical. Surgical treatment is required for these patients; however, it is extremely difficult to resect the lesion due to
severe adhesions to the chest wall and vascular proliferation surrounding the lesion. We performed preoperative arterial embolization,
achieving good results in three patients with hemoptysis caused by pulmonary aspergillosis. The feeding arteries were embolized
using microcoils and/or gelatin sponges, and a lobectomy was safely carried out in all patients. We concluded that preoperative
arterial embolization is a safe and effective technique to prevent massive hemorrhage occurring at the time of surgery.
This work was presented at the 11th Annual Meeting of the Japanese Association for Chest Surgery, held in Kyoto, Japan, May
13–14, 1994 相似文献
90.