全文获取类型
收费全文 | 1846篇 |
免费 | 126篇 |
国内免费 | 28篇 |
学科分类
医药卫生 | 2000篇 |
出版年
2021年 | 26篇 |
2020年 | 14篇 |
2019年 | 30篇 |
2018年 | 41篇 |
2017年 | 28篇 |
2016年 | 24篇 |
2015年 | 41篇 |
2014年 | 36篇 |
2013年 | 41篇 |
2012年 | 58篇 |
2011年 | 59篇 |
2010年 | 57篇 |
2009年 | 46篇 |
2008年 | 44篇 |
2007年 | 67篇 |
2006年 | 76篇 |
2005年 | 47篇 |
2004年 | 45篇 |
2003年 | 57篇 |
2002年 | 34篇 |
2001年 | 33篇 |
2000年 | 36篇 |
1999年 | 44篇 |
1998年 | 74篇 |
1997年 | 81篇 |
1996年 | 87篇 |
1995年 | 52篇 |
1994年 | 46篇 |
1993年 | 50篇 |
1992年 | 36篇 |
1991年 | 35篇 |
1990年 | 41篇 |
1989年 | 63篇 |
1988年 | 54篇 |
1987年 | 55篇 |
1986年 | 46篇 |
1985年 | 43篇 |
1984年 | 20篇 |
1983年 | 20篇 |
1982年 | 14篇 |
1981年 | 20篇 |
1980年 | 18篇 |
1978年 | 9篇 |
1977年 | 19篇 |
1976年 | 13篇 |
1975年 | 11篇 |
1972年 | 7篇 |
1971年 | 15篇 |
1970年 | 9篇 |
1969年 | 12篇 |
排序方式: 共有2000条查询结果,搜索用时 15 毫秒
71.
Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model 下载免费PDF全文
72.
73.
Oral Diseases (2012) 19 , 46–58 Sjögren’s syndrome (SjS) is one of the most common autoimmune rheumatic diseases, clinically characterized by xerostomia and keratoconjunctivitis sicca. We investigated the following controversial topics: (i) Do we have reliable ways of assessing saliva production? (ii) How important are the quantity and quality of saliva? (iii) Are only anti‐SSA/Ro and anti‐SSB/La relevant for the diagnosis of SjS? (iv) Are the American‐European Consensus criteria (AECC) the best way to diagnose SjS? Results from literature searches suggested the following: (i) Despite the fact that numerous tests are available to assess salivation rates, direct comparisons among them are scarce with little evidence to suggest one best test. (ii) Recent developments highlight the importance of investigating the composition of saliva. However, more research is needed to standardize the methods of analysis and collection and refine the quality of the accumulating data. (iii) In addition to anti‐Ro/La autoantibodies, anti α‐fodrin IgA and anti‐MR3 autoantibodies seem to be promising diagnostic markers of SjS, but more studies are warranted to test their sensitivity and specificity. (iv) AECC are classification, not diagnostic criteria. Moreover, recent innovations have not been incorporated into these criteria. Consequently, treatment directed to patients diagnosed using the AECC might exclude a significant proportion of patients with SjS. 相似文献
74.
75.
J Tang DJ Humes E Gemmil NT Welch SL Parsons JA Catton 《Annals of the Royal College of Surgeons of England》2013,95(5):323-328
Introduction
The high mortality and morbidity associated with resection for oesophagogastric malignancy has resulted in a conservative approach to the postoperative management of this patient group. In August 2009 we introduced an enhanced recovery after surgery (ERAS) pathway tailored to patients undergoing resection for oesophagogastric malignancy. We aimed to assess the impact of this change in practice on standard clinical outcomes.Methods
Two cohorts were studied of patients undergoing resection for oesophagogastric malignancy before (August 2008 – July 2009) and after (August 2009 – July 2010) the implementation of the ERAS pathway. Data were collected on demographics, interventions, length of stay, morbidity and in-hospital mortality.Results
There were 53 and 55 oesophagogastric resections undertaken respectively for malignant disease in each of the study periods. The median length of stay for both gastric and oesophageal resection decreased from 15 to 11 days (Mann– Whitney U, p<0.001) following implementation of the ERAS pathway. There was no significant increase in morbidity (gastric resection 23.1% vs 5.3% and oesophageal resection 25.9% vs 16.7%) or mortality (gastric resection no deaths and oesophageal resection 1.8% vs 3.6%) associated with the changes. There was a significant decrease in the number of oral contrast studies used following oesophageal resection, with a reduction from 21 (77.8%) in 2008–2009 to 6 (16.7%) in 2009–2010 (chi-squared test, p<0.0001).Conclusions
The introduction of an enhanced recovery programme following oesophagogastric surgery resulted in a significant decrease in length of median patient stay in hospital without a significant increase in associated morbidity and mortality. 相似文献76.
Sven O. Eicker Frank W. Floeth Marcel Kamp Hans-Jakob Steiger Daniel Hänggi 《European spine journal》2013,22(6):1394-1401
Purpose
5-Aminolevulinic acid (5-ALA)-based fluorescence-guided surgery was shown to be beneficial for cerebral malignant gliomas. Extension of this technique for resection of meningiomas and cerebral metastasis has been recently evaluated. Aim of the present study is to evaluate the impact of fluorescence-guided surgery in spinal tumor surgery.Methods
Twenty-six patients with intradural spinal tumors were included in the study. 5-ALA was administered orally prior to the induction of anesthesia. Intraoperative, 440 nm fluorescence was applied after exploration of the tumor and, if positive, periodically during and at the end of resection to detect tumor-infiltrated sites.Results
Tumors of WHO grade III and IV were found in five patients. In detail intra- or perimedullary metastasis of malignant cerebral gliomas was found including glioblastoma WHO grade IV (n = 2), anaplastic astrocytoma WHO grade III (n = 1), anaplastic oligoastrocytoma WHO grade III (n = 1). In addition, one patient suffered from a spinal drop metastasis of a cerebellar medulloblastoma WHO grade IV. Tumors of WHO grade I were diagnosed in 18 patients: Eight cases of meningioma (two recurrences), six cases of neurinoma, one neurofibroma, two ependymoma and one plexus papilloma. At least, benign pathologies were histologically proven in three patients. All four spinal metastasis of malignant glioma (100 %), seven of eight meningiomas (87.5 %) and one of two ependymoma (50 %) were found to be ALA-positive.Conclusion
The present study demonstrates that spinal intramedullary gliomas and the majority of spinal intradural meningiomas are 5-ALA positive. As a surgical consequence, especially in intramedullary gliomas, the use of 5-ALA fluorescence seems to be beneficial. 相似文献77.
Christopher M. Jack William L. Walter Andrew J. Shimmin Kara Cashman Richard N. de Steiger 《The Journal of arthroplasty》2013
The use of large diameter metal bearing total hip arthroplasty (THA) and hip resurfacing arthroplasty (HRA) increased in popularity in the last decade. More recent literature has highlighted the effect of head size in patient outcomes. Data was obtained from the Australian Orthopaedic Association National Joint Replacement Registry (AOA-NJRR) to evaluate the Birmingham (MoM) bearing surface when used with THA and HRA. There is no difference in the overall rate of revision between the THA and HRA but head size has a significant effect on revision rate. The data show that small diameter metal bearings in HRA (below 50 mm) have a higher rate of revision than large diameter metal bearings in HRA (equal to and above 50 mm) (P < .001). Conversely the large diameter metal bearings in THA have a higher rate of revision than the small diameter metal bearings in THA (P = .027). The revision rate for large diameter HRA compared to small diameter THA is not significantly different P = .670. We recommend caution when choosing either a large diameter (≥ 50 mm) metal on metal THA or small diameter (< 50 mm) HRA. 相似文献
78.
79.
DTS Chang IA Thyer D Hayne DJ Katz 《Annals of the Royal College of Surgeons of England》2014,96(6):e23-e25
Australia has a large migrant population with variable fluency in English. Interpreting services help ensure that healthcare services are delivered appropriately to these populations. However, the use of professional interpreters in hospitals is expensive. There are also issues with service availability and convenience. Mobile devices containing software with translating abilities have promising potential to improve communication between patients and hospital staff as an adjunct to professional interpreters. It is highly convenient and inexpensive. There are concerns about the accuracy of the interpretation done with such software and more research needs to be carried out to support or allay these concerns. For now, clinically important and medicolegal related interpretation should be undertaken by professional interpreters whereas less crucial tasks may be performed with the help of interpreting software on mobile devices. 相似文献
80.