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101.
Application of diffusional kurtosis imaging to detect occult brain damage in multiple sclerosis and neuromyelitis optica
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Wenshu Qian Koon Ho Chan Edward S. Hui Chi Yan Lee Yong Hu Henry Ka‐Fung Mak 《NMR in biomedicine》2016,29(11):1536-1545
Multiple sclerosis (MS) and neuromyelitis optica (NMO) are two common types of inflammatory demyelinating disease of the central nervous system. Early distinction of NMO from MS is crucial but quite challenging. In this study, 13 NMO spectrum disorder patients (Expanded Disability Status Scale (EDSS) of 3.0 ± 1.7, ranging from 2 to 6.5; disease duration of 5.3 ± 4.7 years), 17 relapsing–remitting MS patients (EDSS of 2.6 ± 1.4, ranging from 1 to 5.5; disease duration of 7.9 ± 7.8 years) and 18 healthy volunteers were recruited. Diffusional kurtosis imaging was employed to discriminate NMO and MS patients at the early or stable stage from each other, and from healthy volunteers. The presence of alterations in diffusion and diffusional kurtosis metrics in normal‐appearing white matter (NAWM) and diffusely increased mean diffusivity (MD) in the cortical normal‐appearing gray matter (NAGM) favors the diagnosis of MS rather than NMO. Meanwhile, normal diffusivities and kurtosis metrics in all NAWM as well as increases in MD in the frontal and temporal NAGM suggest NMO. Our results suggest that diffusion and diffusional kurtosis metrics may well aid in discriminating the two diseases. 相似文献
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Hasan Fatih ?ay Ilhan Sezer Mehmet Z. Firat Cahit Ka?ar 《Rheumatology international》2011,31(3):377-385
It is believed that there is an association between the weather and rheumatic symptoms. We aimed to investigate what kind
of association is present and what are the factors which determine the nature of this association. Fifty-six subjects with
rheumatic disease (31 RA, 15 SpA, 10 OA) who live in Antalya were followed between December 2005 and July 2006. Patients were
asked to fill diaries which contain questions regarding the symptoms of their rheumatic diseases everyday. In every monthly
visit, disease activity measurement, laboratory assessment and Beck depression inventory assessment were recorded. The symptomatic
and psychological measurements were matched with the meteorological data of Antalya Regional Directorate of Meteorological
Service of Turkish State. Correlation of symptoms with weather variables was investigated. Contributory effect of weather
and of psychologic factors on symptom scores were evaluated by stepwise multiple regression analysis. Eighty-four percent
of subjects belive in an association between weather and rheumatism, while 57% claimed to have ability to forecast weather.
The maximum correlation coefficient between weather and arthritis symptoms was −0.451 and the maximum contribution of weather
on symptoms was 17.1%. Arthritis symptoms were significantly contributed by Beck depression score. The belief about presence
of weather–arthritis association was found to be stronger than its statistical power. Our results did not prove or rule out
the presence of weather–rheumatism association. As long as the scientific attempts result in failure, the intuitive support
in favour of the presence of weather–arthritis association will go on forever. 相似文献
105.
İnsaf Altun Nursan Dede Çınar Mağfiret Kara Kaşıkçı 《International Journal of Urological Nursing》2012,6(2):91-93
Water is an essential nutrient and adequate intake and output of water is required for health maintenance. Water homeostasis is vital for life and optimal function and considerable interest surrounds the issue of recommendations for water consumption in healthy individuals. Few studies are available about self‐reported water intake and urine output. The aim of this study was to assess the quantity of water intake and urine output in 24‐h period in healthy young individuals. This prospective study was carried out on 31 students aged 18–24 years undergoing nursing education in a University during January 2011 in Sakarya, Turkey. Healthy young individuals were recruited for determination of the quantity of water taken in and urine excretion along 24 h; they recorded fluid input and urine output. The students collected the data during weekend break. In our study, the total daily fluid intake (mL) for females was 2082·6 ± 687·1 and the total daily fluid intake (mL) for males was 2720·8 ± 717·4. The total daily quantity of urine (mL) for females was 1623·4 ± 602·4 and the total daily quantity of urine (mL) for males was 1818·3 ± 420·6. This research may be the source for similar studies that could include seasonal changes, climates, cultures and different age groups. 相似文献
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Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general belief that the problem of bacterial infections would be solved. Nonetheless, pathogens including staphylococci have evolved mechanisms of drug resistance. Among current attempts to address this problem, phage therapy offers a promising alternative to combat staphylococcal infections. Here, we present an overview of current knowledge on staphylococcal infections and bacteriophages able to kill Staphylococcus, including experimental studies and available data on their clinical use. 相似文献
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Nguyen Van Vinh Chau Nguyen Thi Thu Hong Nghiem My Ngoc Tran Tan Thanh Phan Nguyen Quoc Khanh Lam Anh Nguyet Le Nguyen Truc Nhu Nguyen Thi Han Ny Dinh Nguyen Huy Man Vu Thi Ty Hang Nguyen Thanh Phong Nguyen Thi Hong Que Pham Thi Tuyen Tran Nguyen Hoang Tu Tran Tinh Hien Ngo Ngoc Quang Minh Le Manh Hung Nguyen Thanh Truong Lam Minh Yen H. Rogier van Doorn Nguyen Thanh Dung Guy Thwaites Nguyen Tri Dung Le Van Tan for the OUCRU COVID- research group 《Emerging infectious diseases》2021,27(1):310
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