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91.
Surucu Yilmaz Naz Bilgic Eltan Sevgi Kayaoglu Basak Geckin Busranur Heredia Raul Jimenez Sefer Asena Pinar Kiykim Ayca Nain Ercan Kasap Nurhan Dogru Omer Yucelten Ayse Deniz Cinel Leyla Karasu Gulsun Yesilipek Akif Sozeri Betul Kaya Goksu Gokberk Yilmaz Ismail Cem Baydemir Ilayda Aydin Yagmur Cansen Kahraman Deniz Haimel Matthias Boztug Kaan Karakoc-Aydiner Elif Gursel Ihsan Ozen Ahmet Baris Safa Gursel Mayda 《Journal of clinical immunology》2022,42(3):582-596
Journal of Clinical Immunology - NF-κB essential modulator (NEMO, IKK-γ) deficiency is a rare combined immunodeficiency caused by mutations in the IKBKG gene. Conventionally, patients are... 相似文献
92.
Aydin G Keleş I Ozbudak Demir S Baysal AI 《American journal of physical medicine & rehabilitation / Association of Academic Physiatrists》2004,83(1):17-21
OBJECTIVE: To compare the sensitivity of median sensory nerve conduction tests performed by stimulating digital branches in patients with carpal tunnel syndrome. DESIGN: A prospective study in 506 hands of patients with carpal tunnel syndrome diagnosed electrophysiologically. RESULTS: The sensitivity of median sensory nerve conduction tests across the first three digit-to-wrist segments and palm-to-wrist segment was determined. The most common abnormal electrophysiologic finding was the slowing of sensory nerve conduction velocity over the palm-to-wrist segment, which was detected in 98.5% of the hands. Slowing of sensory nerve conduction velocity over the digit 1-, 2-, and 3-to-wrist segments of the median nerve was found in 95.4%, 88%, and 82% of the hands, respectively. CONCLUSION: The sensory nerve conduction velocity test of the digit 1-to-wrist segment has the most sensitivity among the three digital branches of the median sensory nerve, and it may be used more widely in the electrodiagnosis of carpal tunnel syndrome. 相似文献
93.
Esra Circi Sibel Caglar Okur Ozge Aksu Erhan Mumcuoglu Tolga Tuzuner Nil Caglar 《Acta orthopaedica et traumatologica turcica》2018,52(1):17-21
Objective
The aim of this study was to evaluate the effectiveness of the extracorporeal shock wave therapy in the subacromial impingement syndrome and its relationship with the acromion morphology.Methods
Thirty patients (24 women, 6 men) with subacromial impingement were evaluated. The average age of patients was 53.6 ± 9.8 years (range 39–80). Patients were divided into 3 groups according to the acromion morphology. ESWT 1500 at 0.12 am mL/mm2 violence was applied once a week for 3 weeks. Shoulder pain and disability index (SPADI) was used to assess function and pain scores of the patients. The evaluations were made prior to and 12 weeks after the ESWT.Results
Thirteen shoulders had type 1 acromion, 11 shoulders type 2 acromion and 6 shoulders type 3 acromion. After ESWT, the SPADI pain score decreased from 16.1 ± 5.1 (7–25) to 10.4 ± 4.9 (1–20); SPADI functional score decreased from 37.3 ± 19.8 (5–70) to 26.7 ± 17.5 (1–60); SPADI total score decreased from 53.4 ± 24.5 (14–95) to 37.1 ± 21.6 (2–74) (p < 0.05; paired t test). In each group better functional outcomes were achieved after ESWT (p < 0.05; paired t test). There were no differences between the groups according to functional outcome both before and after the ESWT treatment (p > 0.05, one way ANOVA test).Conclusion
ESWT was found to be effective in the treatment of impingement syndrome both for pain and functional outcome in the early period regardless of acromion morphology.Level of evidence
Level IV, Therapeutic study. 相似文献94.
Ismail Cem Yilmaz Emre Mert Ipekoglu Artun Bulbul Nilsu Turay Muzaffer Yildirim Irem Evcili Naz Surucu Yilmaz Nese Guvencli Yagmur Aydin Bilgi Gungor Berfu Saraydar Asli Gulce Bartan Bilgehan Ibibik Tugce Bildik layda Baydemir Hatice Asena Sanli Basak Kayaoglu Yasemin Ceylan Tugce Yildirim Irem Abras Ihsan Cihan Ayanoglu Sefa Burak Cam Eda Ciftci Dede Merve Gizer Osman Erganis Fahriye Sarac Serdar Uzar Hakan Enul Cumhur Adiay Gamze Aykut Hivda Polat Ismail Selim Yildirim Saban Tekin Gulay Korukluoglu Hasan Ersin Zeytin Petek Korkusuz Ihsan Gursel Mayda Gursel 《Allergy》2022,77(1):258-270
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Dokucu AI Ozturk H Ozturk H Tuncer MC Yilmaz F 《International urology and nephrology》2009,41(1):101-108
This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible
factor alpha (HIF-1α) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion
(I-R) injury. Torsions were created by rotating ipsilateral testes 720° in a clockwise direction for 6 h and 1-h detorsion
of the testis was performed. A sham operation was performed in group 1 (control, n = 7). In group 2 (I-R/Untreated, n = 7), following 6 h of unilateral testicular torsion, 1-h detorsion of the testis was performed. No drug was given. In group
3 (I-R/MO), after performing the same surgical procedure as in group 2, a NO donor MO was given at the starting time of reperfusion.
In group 4 (I-R/L-NAME), after performing the same surgical procedure as in group 2, L-NAME was given at the starting time
of reperfusion. Testes malondialdehyde (MDA) levels were determined as well as examining the testes histologically. Treatment
of rats with MO produced a significant reduction in the levels of MDA and histopathological score compared to testes I-R groups.
The Sonic hedgehog (Shh) expression in the basement membrane of the tubuli seminiferi, and sertoli and germinal cells in testicular
tissue, were greatly increased in the I-R/MO group compared to groups 1, 2 and 4. Additionally, the HIF-1α expression in the
interstitial spaces in testicular tissue were greatly increased in the I-R/MO group. The results suggest that MO has a protective
effect against ischemia/reperfusion injury in rat testes and may affect Shh and HIF-1α signaling pathway. 相似文献
98.
Cem Ismail Kucukali Makbule Aydin Elif Ozkok Emine Bilge Nurcan Orhan Asli Zengin Ihsan Kara 《Progress in neuro-psychopharmacology & biological psychiatry》2009
There is growing evidence of partial etiological overlap between schizophrenia (SZ) and bipolar I disorder (BD-I) from linkage analysis, genetic epidemiology and molecular genetics studies. SZ and BD-I are neurodevelopmental disorders with genetic and environmental etiologies. Recent studies have demonstrated that matrix metalloproteinase 3 (MMP3) is a key event in associative memory formation, learning and synaptic plasticity, which are important in psychiatric disorders. In the light of these findings, we analyzed the genetic variations in the MMP3-1171 5A/6A in patients with SZ, patients with BD-I and healthy controls. To the best of our knowledge, this is the first study to report an association of variation in gene encoding MMP3 with SZ. Our study group consisted of 111 unrelated patients with SZ, 141 unrelated patients with BD-I, and 121 unrelated healthy controls. The frequencies of 6A6A genotype and 6A allele distributions of MMP3 in patients with SZ were significantly decreased when compared with controls. In contrast, in patients with SZ, the distributions of 5A5A genotype and 5A allele of MMP3 gene were significantly increased as compared with healthy controls. When the frequencies of genotypes or alleles in schizophrenic patients and bipolar patients were compared, 6A6A genotype and 6A allele in patients with BD-I were significantly higher than patients with SZ. In contrast, 5A5A genotype and 5A allele distributions of MMP3 gene were significantly frequent in patients with SZ. On the other hand, no significant differences were found in the allele or genotype distribution in patients with BD-I compared with controls. In conclusion, our data have supported the hypothesis that there is a possible relationship between − 1171 5A/6A polymorphism of MMP3 gene and SZ. A larger sample group is needed to confirm the potential role of this gene in the pathophysiology of psychiatric disorders. 相似文献
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100.
Umit Dundar Vural Kavuncu Ihsan H. Ciftci Deniz Evcik Ozlem Solak Tuncay Cakir 《Journal of bone and mineral metabolism》2009,27(4):464-470
There is much evidence suggesting that the decline in ovarian function after menopause is associated with spontaneous increases
in proinflammatory cytokines. Treatment with risedronate is accompanied by significant changes in bone turnover and bone mineral
density. The objective of this study was to determine the effects of risedronate treatment on the level of serum cytokines
including receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin among postmenopausal women with osteoporosis.
The study group consisted of 61 postmenopausal women with osteoporosis. Patients were randomly divided in two groups: In group
1 (n = 41) postmenopausal women received oral risedronate (35 mg/week), calcium (1,000 mg/day), and vitamin D (400 IU/day) for
12 months. In group 2 (control group; n = 20) patients received only oral calcium (1,000 mg/day) and vitamin D (400 IU/day). Bone mineral density (BMD) of lumbar
spine (L1–L4) and proximal femur were determined using dual X-ray absorptiometry at baseline and after one year. Venous blood
samples were obtained for determination of serum cytokines including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α),
RANKL, osteoprotegerin, and markers of bone formation and resorption. Levels of serum cytokines were measured before therapy
and after three and 6 months. Markers of bone metabolism were studied before therapy and after 6 months. In group 1 (risedronate
plus calcium/vitamin D-treated patients), serum levels of RANKL and IL-1β significantly decreased and the level of osteoprotegerin
significantly increased after three and 6 months, but no significant difference was found in TNF-α level. In group 2, however,
the level of serum cytokines did not change after three and 6 months. In cases of bone turnover, both markers of bone resorption
and formation significantly decreased after 6 months in group 1. In conclusion risedronate could improve osteoporosis by increasing
osteoprotegerin and reducing RANKL and IL-1β. 相似文献