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91.
Ismail Cem Yilmaz Emre Mert Ipekoglu Artun Bulbul Nilsu Turay Muzaffer Yildirim Irem Evcili Naz Surucu Yilmaz Nese Guvencli Yagmur Aydin Bilgi Gungor Berfu Saraydar Asli Gulce Bartan Bilgehan Ibibik Tugce Bildik layda Baydemir Hatice Asena Sanli Basak Kayaoglu Yasemin Ceylan Tugce Yildirim Irem Abras Ihsan Cihan Ayanoglu Sefa Burak Cam Eda Ciftci Dede Merve Gizer Osman Erganis Fahriye Sarac Serdar Uzar Hakan Enul Cumhur Adiay Gamze Aykut Hivda Polat Ismail Selim Yildirim Saban Tekin Gulay Korukluoglu Hasan Ersin Zeytin Petek Korkusuz Ihsan Gursel Mayda Gursel 《Allergy》2022,77(1):258-270
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93.
Two generation reproduction and teratogenicity studies of feeding cyadox in Wistar rats 总被引:1,自引:0,他引:1
Xu WangGui-Jie Fang Yu-Lian WangAwais Ihsan Ling-Li HuangWen Zhou Zhen-Li LiuZong-Hui Yuan 《Food and chemical toxicology》2011,49(5):1068-1079
To investigate the teratogenic potential and reproductive toxicity of cyadox, a growth promoting agent, Wistar rats (F0) were fed with diets containing cyadox (0, 50, 150 and 2500 mg/kg) or olaquindox (150 mg/kg), approximately equivalent to cyadox 5, 15, 250 or olaquindox 15 mg/kg b.w./day across two generations. Half of the pregnant rats (F0, F1b) were subjected to caesarean section on gestational day 20 for teratogenic examination and the other half produced pups F1a and F2a, respectively. At the 250 mg/kg b.w./day cyadox group, body weights of F1b pregnant rats and F2a on day 21 after birth decreased; fetal body lengths and tail lengths decreased; the number of fetal resorptions increased significantly; litter weights, number of viable fetuses decreased; number of embryo resorptions increased significantly; number of liveborn F1a, F1b and F2a decreased. No macroscopic or microscopic change of any significance was found in the reproductive organs. Significant increases in the incidence of cervial ribs or lumbar ribs in F2a pups and significant increases of relative organ weight of testis and epididymis in F1b were observed at the 250 mg/kg b.w./day cyadox group. The NOAEL for reproduction/development of cyadox for rats was estimated to be 150 mg/kg diet, which was equivalent to approximately 15 mg/kg b.w./day. 相似文献
94.
Cornelius JR Douaihy A Bukstein OG Daley DC Wood SD Kelly TM Salloum IM 《Addictive behaviors》2011,36(8):843-848
Objective
Behavioral therapies developed specifically for co-occurring disorders remain sparse, and such therapies for comorbid adolescents are particularly rare. This was an evaluation of the long-term (2-year) efficacy of an acute phase trial of manualized cognitive behavioral therapy/motivation enhancement therapy (CBT/MET) vs. naturalistic treatment among adolescents who had signed consent for a treatment study involving the SSRI antidepressant medication fluoxetine and CBT/MET therapy for comorbid major depressive disorder (MDD) and an alcohol use disorder (AUD). We hypothesized that improvements in depressive symptoms and alcohol-related symptoms noted among the subjects who had received CBT/MET would exceed that of those in the naturalistic comparison group that had not received CBT/MET therapy.Methods
We evaluated levels of depressive symptoms and alcohol-related symptoms at a two-year follow-up evaluation among comorbid MDD/AUD adolescents who had received an acute phase trial of manual-based CBT/MET (in addition to the SSRI medication fluoxetine or placebo) compared to those who had received naturalistic care.Results
In repeated measures ANOVA, a significant time by enrollment status difference was noted for both depressive symptoms and alcohol-related symptoms across the two-year time period of this study, with those receiving CBT/MET demonstrating superior outcomes compared to those who had not received protocol CBT/MET therapy. No significant difference was noted between those receiving fluoxetine vs. those receiving placebo on any outcome at any time point.Conclusions
These findings suggest long-term efficacy for an acute phase trial of manualized CBT/MET for treating comorbid MDD/AUD adolescents. Large multi-site studies are warranted to further clarify the efficacy of CBT/MET therapy among various adolescent and young adult comorbid populations. 相似文献95.
96.
97.
Dokucu AI Ozturk H Ozturk H Tuncer MC Yilmaz F 《International urology and nephrology》2009,41(1):101-108
This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible
factor alpha (HIF-1α) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion
(I-R) injury. Torsions were created by rotating ipsilateral testes 720° in a clockwise direction for 6 h and 1-h detorsion
of the testis was performed. A sham operation was performed in group 1 (control, n = 7). In group 2 (I-R/Untreated, n = 7), following 6 h of unilateral testicular torsion, 1-h detorsion of the testis was performed. No drug was given. In group
3 (I-R/MO), after performing the same surgical procedure as in group 2, a NO donor MO was given at the starting time of reperfusion.
In group 4 (I-R/L-NAME), after performing the same surgical procedure as in group 2, L-NAME was given at the starting time
of reperfusion. Testes malondialdehyde (MDA) levels were determined as well as examining the testes histologically. Treatment
of rats with MO produced a significant reduction in the levels of MDA and histopathological score compared to testes I-R groups.
The Sonic hedgehog (Shh) expression in the basement membrane of the tubuli seminiferi, and sertoli and germinal cells in testicular
tissue, were greatly increased in the I-R/MO group compared to groups 1, 2 and 4. Additionally, the HIF-1α expression in the
interstitial spaces in testicular tissue were greatly increased in the I-R/MO group. The results suggest that MO has a protective
effect against ischemia/reperfusion injury in rat testes and may affect Shh and HIF-1α signaling pathway. 相似文献
98.
Cem Ismail Kucukali Makbule Aydin Elif Ozkok Emine Bilge Nurcan Orhan Asli Zengin Ihsan Kara 《Progress in neuro-psychopharmacology & biological psychiatry》2009
There is growing evidence of partial etiological overlap between schizophrenia (SZ) and bipolar I disorder (BD-I) from linkage analysis, genetic epidemiology and molecular genetics studies. SZ and BD-I are neurodevelopmental disorders with genetic and environmental etiologies. Recent studies have demonstrated that matrix metalloproteinase 3 (MMP3) is a key event in associative memory formation, learning and synaptic plasticity, which are important in psychiatric disorders. In the light of these findings, we analyzed the genetic variations in the MMP3-1171 5A/6A in patients with SZ, patients with BD-I and healthy controls. To the best of our knowledge, this is the first study to report an association of variation in gene encoding MMP3 with SZ. Our study group consisted of 111 unrelated patients with SZ, 141 unrelated patients with BD-I, and 121 unrelated healthy controls. The frequencies of 6A6A genotype and 6A allele distributions of MMP3 in patients with SZ were significantly decreased when compared with controls. In contrast, in patients with SZ, the distributions of 5A5A genotype and 5A allele of MMP3 gene were significantly increased as compared with healthy controls. When the frequencies of genotypes or alleles in schizophrenic patients and bipolar patients were compared, 6A6A genotype and 6A allele in patients with BD-I were significantly higher than patients with SZ. In contrast, 5A5A genotype and 5A allele distributions of MMP3 gene were significantly frequent in patients with SZ. On the other hand, no significant differences were found in the allele or genotype distribution in patients with BD-I compared with controls. In conclusion, our data have supported the hypothesis that there is a possible relationship between − 1171 5A/6A polymorphism of MMP3 gene and SZ. A larger sample group is needed to confirm the potential role of this gene in the pathophysiology of psychiatric disorders. 相似文献
99.
100.
Umit Dundar Vural Kavuncu Ihsan H. Ciftci Deniz Evcik Ozlem Solak Tuncay Cakir 《Journal of bone and mineral metabolism》2009,27(4):464-470
There is much evidence suggesting that the decline in ovarian function after menopause is associated with spontaneous increases
in proinflammatory cytokines. Treatment with risedronate is accompanied by significant changes in bone turnover and bone mineral
density. The objective of this study was to determine the effects of risedronate treatment on the level of serum cytokines
including receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin among postmenopausal women with osteoporosis.
The study group consisted of 61 postmenopausal women with osteoporosis. Patients were randomly divided in two groups: In group
1 (n = 41) postmenopausal women received oral risedronate (35 mg/week), calcium (1,000 mg/day), and vitamin D (400 IU/day) for
12 months. In group 2 (control group; n = 20) patients received only oral calcium (1,000 mg/day) and vitamin D (400 IU/day). Bone mineral density (BMD) of lumbar
spine (L1–L4) and proximal femur were determined using dual X-ray absorptiometry at baseline and after one year. Venous blood
samples were obtained for determination of serum cytokines including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α),
RANKL, osteoprotegerin, and markers of bone formation and resorption. Levels of serum cytokines were measured before therapy
and after three and 6 months. Markers of bone metabolism were studied before therapy and after 6 months. In group 1 (risedronate
plus calcium/vitamin D-treated patients), serum levels of RANKL and IL-1β significantly decreased and the level of osteoprotegerin
significantly increased after three and 6 months, but no significant difference was found in TNF-α level. In group 2, however,
the level of serum cytokines did not change after three and 6 months. In cases of bone turnover, both markers of bone resorption
and formation significantly decreased after 6 months in group 1. In conclusion risedronate could improve osteoporosis by increasing
osteoprotegerin and reducing RANKL and IL-1β. 相似文献