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91.
Okamoto H Hagiwara H Naganuma H Itakura J Nagahori K Fujii H Yamamoto M Sekikawa T Matsumoto Y 《Breast cancer (Tokyo, Japan)》1996,3(2):145-150
We report a case of ductal carcinoma in situ (DCIS) of the breast detected by ultrasonographic mass screening in a 51-year-old woman. In a mass screening program for breast cancer, physical examination with inspection and palpation, and ultrasonography (US) were performed. A hypoechoic mass with a slightly irregular margin was detected by US in the lateral upper quadrant of the right breast, at a distance 2 cm from the edge of the nipple. The mass was not detected by physical examinations or by mammography (MMG). The mass, which measured 0.8 x 0.5 cm and was examined by fine needle aspiration biopsy (FNAB) under US guidance, was cytologically diagnosed as class X. Modified radical mastectomy (Auchincloss method) was performed with the patient's consent. Pathological examination of the resected specimen revealed DCIS (noncomedo type) and occult multiple foci of malignancy which was considered tracking centripetally underneath the nipple. This case suggests that US and FNAB performed under US guidance are useful in the detection and diagnosis, respectively, of a breast mass. We should take multifocality into consideration, particularly with tendency tracking to the nipple, in the treatment of small breast cancers such as DCIS. 相似文献
92.
Hideki Horita M.D. Eiichi Hoashi M.D. Yuko Okuyama M.D. Koumei Kumagai M.D. Shiro Endo M.D. 《Psychiatry and clinical neurosciences》1977,31(3):393-402
We observed the attacks of nystagmus in a case of infantile spasms and carried out overnight sleep polygraphy. The following findings were obtained:
- 1 Awake time was prolonged to 56% of TIB, while sleep time was markedly shortened to 44% of TIB. Also REM sleep time was reduced to 20% of SPT and deep slow sleep (stage N3) was absent.
- 2 Attacks of nystagmus were observed only during wakefulness. At first, fast wave bursts appeared in the right occipital area, and were followed by left-upward deviations of eyeballs, and then the attacks of counterclockwise right-downward rotatory nystagmus. Also the fast wave bursts were succeeded by spreading of fast waves to adjacent areas. At the same time, EMG exhibited elevated muscle action potentials of mentalis and biceps fernoris. During the attacks of nystagmus, there was alteration of respiratory movements.
93.
94.
Yusuke Demizu Kazufumi Kagawa Yasuo Ejima Hideki Nishimura Ryohei Sasaki Toshinori Soejima Toshihiro Yanou Masakazu Shimizu Yoshiya Furusawa Yoshio Hishikawa Kazuro Sugimura 《Radiotherapy and oncology》2004,71(2):207-211
We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray. 相似文献
95.
Osamu Miyamoto Takehiro Nakamura Shin-ich Yamagami Tetsuro Negi Masaaki Tokuda Hideki Matsui Toshifumi Itano 《Brain research》2000,873(1):418
To investigate the mechanism of chronic cell death following postischemic hypothermia, the change of N-methyl-
-aspartate receptor (NMDAR) were examined by immunohistochemistry of NMDAR1 and long-term potentiation (LTP) in the CA1 subfield of the gerbil hippocampus. At 1 week following postischemic hypothermia (32°C×4 h), all CA1 neurons survived; however, immunoreactivity of NMDAR1 increased in neuronal perikarya whereas decreased in dendrites in the CA1 neurons. The abnormality was still observed in remaining CA1 neurons at 1 month after hypothermia. LTP was also significantly depressed at 1 week after hypothermia. These results suggest that some abnormalities in the glutamate receptor may be caused by ischemia; such abnormality would persist in spite of hypothermia treatment, resulting in the depression of LTP. 相似文献
96.
Masakatsu Fujinoki Tatsuya Suzuki Takeshi Takayama Hiroaki Shibahara Hideki Ohtake 《Reproductive Medicine and Biology》2006,5(2):123-135
Background and Aims It has been widely accepted that sperm hyperactivation is regulated by protein phosphorylations. But, the sperm hyperactivation
phosphorylation pathway is not well understood yet because several different proteins have been detected in other studies.
In order to understand the phosphorylation pathway that regulates hyperactivation, we established how to extract sperm protein
completely and detected proteins that were phosphorylated during hyperactivation.
Methods Protein phosphorylation of hamster spermatozoa was detected by western blotting using antiphospho-amino acid monoclonal antibodies
or the SELDI ProteinChip system with IMAC-Ga(III).
Results We detected 75 protein/peptide phosphoryations using the method established in the present study. Tyrosine phosphorylations
occurred during hyperactivation. Serine or threonine phosphorylations occurred for 30 min. Furthermore, four of the serine
or threonine phosphorations were phosphorylated by A-kinase. As for peptides, 15 peptides were dephosphorylated for 30 min.
Other peptides were phosphorylated during hyperactivation.
Conclusions Because most of the proteins detected in the present study have been described previously, we could detect comprehensive protein
phosphorylations. Moreover, we also detected many novel phosphopeptides. Although we did not understand the role of peptide,
it was likely that motility was basically regulated by serine/threonine phosphorylations and hyperactivation was mainly regulated
by tyrosine phosphorylations. (Reprod Med Biol 2006; 5: 123–135) 相似文献
97.
Takao Imai Noriaki Takeda Mahito Ito Koji Nakamae Hideki Sakae Hiromu Fujioka Takeshi Kubo 《Otology & neurotology》2006,27(3):362-366
OBJECTIVE: To show the positional nystagmus in a patient who had suffered from benign paroxysmal positional vertigo (BPPV) that was thought to be caused by involvement of the anterior semicircular canal (ASCC) (A-BPPV). STUDY DESIGN: Retrospective case report. SETTING: City hospital. PATIENT: The present study reports a rare case of A-BPPV in a 41-year-old woman. CASE REPORT: The patient is 41-year-old woman who developed a positional vertigo after playing volleyball on March 22, 2005 and consulted our hospital the next day. When left Dix-Hallpike maneuver was performed, she showed a positional nystagmus of which fast phase direction of the torsional component was clockwise while that of the vertical component was downward. We plotted the slow phase eye velocity of the positional nystagmus during the left Dix-Hallpike maneuver on three-dimensional coordinates that showed the axis of the positional nystagmus to be perpendicular to the plane of the right ASCC. CONCLUSION: These results suggested that the patient was suffering from A-BPPV. 相似文献
98.
Hideki Watanabe Hiromi Hamada Yutaka Fujiki Sawako Takeuchi Kuni Urushigawa Hiroyuki Yoshikawa 《Hypertension in pregnancy》2006,25(1):33-35
Visual disturbances occur more frequently during preeclampsia than during pregnancy in general, but visual disturbances due to cranial nerve palsy are rare. We present the case of a 35-year-old preeclamptic woman with left third nerve palsy and left serous retinal detachment. The patient complained of visual disturbance and double vision soon after cesarean section. Left third nerve palsy and left serous retinal detachment were diagnosed by urgent ophthalmologic evaluation. Aneurysm and organic brain lesion were ruled out by diagnostic imaging. By 2 months postpartum, the visual disturbance had improved spontaneously. 相似文献
99.
Tetsuya Mitsudomi Takayuki Kosaka Hideki Endoh Yoshitsugu Horio Toyoaki Hida Shoichi Mori Shunzo Hatooka Masayuki Shinoda Takashi Takahashi Yasushi Yatabe 《Journal of clinical oncology》2005,23(11):2513-2520
PURPOSE: To evaluate the relationship between mutations of the epidermal growth factor receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent lung cancer after pulmonary resection. PATIENTS AND METHODS: We sequenced exons 18-21 of the EGFR gene using total RNA extracted from 59 patients with lung cancer who were treated with gefitinib for recurrent lung cancer. Gefitinib effectiveness was evaluated by both imaging studies and change in serum carcinoembryonic antigen (CEA) levels. RESULTS: EGFR mutations were found in 33 patients (56%). Of these mutations, 17 were deletions around codons 746-750 and 15 were point mutations (12 at codon 858, three at other codons), and one was an insertion. EGFR mutations were significantly more prevalent in females, adenocarcinoma, and never-smokers. Gefitinib treatment resulted in tumor shrinkage and/or CEA decrease to less than half of the baseline level in 26 patients, tumor growth and/or CEA elevation in 24 patients, and gefitinib effect was not assessable in nine patients. Female, never-smoking patients with adenocarcinoma tended to respond better to gefitinib treatment. Gefitinib was effective in 24 of 29 patients with EGFR mutations, compared with two of 21 patients without mutations (P < .0001). Of note, del746-750 might be superior to L858R mutations for prediction of gefitinib response. Patients with EGFR mutations survived for a longer period than those without the mutations after initiation of gefitinib treatment (P = .0053). CONCLUSION: EGFR mutations were a good predictor of clinical benefit of gefitinib in this setting. 相似文献
100.
Kousaku Mimura Koji Kono Mitsuhiko Hanawa Mirei Kanzaki Atsuhito Nakao Akishi Ooi Hideki Fujii 《Clinical cancer research》2005,11(13):4898-4904
PURPOSE: In the present study, we investigated the degree of protein expression and gene amplification of HER-2 in esophageal squamous cell carcinoma (SCC) cell lines and freshly isolated tumors, and trastuzumab-mediated biological activity, in particular antibody-dependent cellular cytotoxicity (ADCC) against HER-2-expressing esophageal SCC cell lines. EXPERIMENTAL DESIGN: Ten different SCC cell lines with various levels of HER-2 status evaluated by flow cytometry, immunocytochemistry (HercepTest), and fluorescence in situ hybridization were evaluated for ADCC, growth inhibitory, or apoptosis-inducing activities mediated by trastuzumab. RESULTS: Trastuzumab induced ADCC against HER-2-expressing esophageal SCC and the activities reflected the degree of HER-2 expression analyzed by flow cytometric analysis, but not by HercepTest nor fluorescence in situ hybridization analysis. Furthermore, trastuzumab-mediated ADCC against transforming growth factor-beta-producing SCC was enhanced by the treatment with SB-431542, which is a selective inhibitor of the phosphorylation induced by transforming growth factor-beta. There were very marginal effects of anti-proliferative or apoptosis-inducing activities mediated by trastuzumab for HER-2-expressing esophageal SCC. CONCLUSION: HER-2-expressing esophageal SCC cells could be killed by trastuzumab-mediated ADCC and the activity reflected the degree of HER-2 expression detected by flow cytometry. 相似文献