全文获取类型
收费全文 | 1132篇 |
免费 | 131篇 |
国内免费 | 2篇 |
学科分类
医药卫生 | 1265篇 |
出版年
2024年 | 3篇 |
2023年 | 25篇 |
2022年 | 25篇 |
2021年 | 46篇 |
2020年 | 41篇 |
2019年 | 43篇 |
2018年 | 98篇 |
2017年 | 56篇 |
2016年 | 85篇 |
2015年 | 74篇 |
2014年 | 107篇 |
2013年 | 147篇 |
2012年 | 82篇 |
2011年 | 73篇 |
2010年 | 64篇 |
2009年 | 37篇 |
2008年 | 27篇 |
2007年 | 28篇 |
2006年 | 35篇 |
2005年 | 23篇 |
2004年 | 14篇 |
2003年 | 19篇 |
2002年 | 11篇 |
2001年 | 19篇 |
2000年 | 9篇 |
1999年 | 14篇 |
1998年 | 17篇 |
1997年 | 6篇 |
1996年 | 7篇 |
1995年 | 10篇 |
1994年 | 8篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1981年 | 1篇 |
排序方式: 共有1265条查询结果,搜索用时 15 毫秒
61.
Türk İpek Cüzdan Nihan Çiftçi Volkan Arslan Didem Doğan Muharrem Cem Unal İlker 《Clinical rheumatology》2020,39(1):57-67
Clinical Rheumatology - The aim of this study was to evaluate the associations between malnutrition and the clinical features of the disease and depression in patients with systemic sclerosis... 相似文献
62.
Yayla Müçteba Enes İlgen Ufuk Okatan İlyas Ercan UsluYurteri Emine Torgutalp Murat Keleşoğlu Dinçer Ayşe Bahar Aydemir Gülöksüz Emine Gözde Sezer Serdar Turgay Tahsin Murat Kınıklı Gülay Ateş Aşkın 《Clinical rheumatology》2020,39(1):77-83
Clinical Rheumatology - Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), mean platelet volume (MPV), and red cell distribution width (RDW) may potentially reflect... 相似文献
63.
64.
Evrim Kiray Ba? Ali Bülbül Serdar C?mert Sinan Uslu Selda Arslan Asiye Nuhoglu 《Journal of clinical microbiology》2014,52(9):3478-3482
Neisseria meningitidis is one of the major causes of meningitis in children and adolescents, but it is rarely found during the neonatal period. Here, we describe a neonate with meningococcal sepsis who was admitted to the hospital on postnatal day 10, and we discuss the clinical features of neonatal infection with N. meningitidis in relation to the literature (analysis of a 97-year period). 相似文献
65.
Çağlar Ödek Tanıl Kendirli Figen Doğu Ayhan Yaman Göksel Vatansever Funda Çipe Şule Haskoloğlu Can Ateş Erdal İnce Aydan İkincioğulları 《Journal of clinical immunology》2014,34(3):309-315
Purposes
The aims of this study were to review the frequency, characteristics, and the clinical course of primary immunodeficiency (PID) patients admitted to pediatric intensive care unit (PICU) and attempt to identify factors related with mortality that might predict a poor outcome.Methods
We performed a retrospective review of children with PID aged 1 month to 18 years and admitted to PICU from January 2002 to January 2012 in our tertiary teaching children’s hospital.Results
There were a total of 51 patients accounting for 71 admissions to the PICU. The most common diagnosis was severe combined immunodeficiency. Respiratory problems were the leading cause for admission. A total of 20 patients received hematopoietic stem cell transplantation. Immune reconstitution was achieved in 9 (45 %) patients and eight of them did survive. In all 56 % of all admission episodes resulted in survival. Risk factors for mortality included requirement of mechanical ventilation (P?<?.001), number of organ system failure (P?=?.013), need for renal replacement therapy (P?<?.001), use of inotropes (P?<?.001), higher Pediatric Logistic Organ Dysfunction (PELOD) score (P?=?.005), and length of PICU stay (P?<?.001).Conclusions
This is the first study regarding the outcome and mortality-related risk factors for PID patients requiring PICU admission. We suggest that PICU management is as important as early diagnosis and treatment for these patients. Prediction of those at risk for poorer outcome might be beneficial for accurate intensive care management and survival. 相似文献66.
Ayşe İpek Kalafatçılar Özlem Tüfekçi Semra Hız Handan Güleryüz Aynur Akay 《Pediatric hematology and oncology》2014,31(2):181-193
The neurologic dysfunctions caused by treatment may affect health and quality of life in survivors of childhood leukemia. The objective of this study was to identify the neuropsychological late effects of leukemia treatment to provide an assessment about the degree and incidence of these late effects. Neurological and ophtalmological examination, cranial magnetic resonance imaging (MRI), auditory and neurocognitive tests, and questionnaires of quality of life were performed to 44 acute leukemia survivors at least 5 years after diagnosis. Median time since completion of chemotherapy was 7.5 years (2–18) and median age at the time of the study was 16.4 years (8–31). At least one or more late effects detected by physical examination (PE), neurological tests, or neurocognitive tests encountered in 80% of the patients, and 64% of the patients specified at least one complaint in the quality of life questionnaire. MRI revealed pathological findings in 18% and electroencephalogram (EEG) abnormalities were present in 9% of the patients. Evaluation of total intelligence scores revealed that 30% of patients’ IQ scores were <80 and 70% of the patients’ scores demonstrated neurocognitive dysfunctions. The patients >6 years at the time of diagnosis were found to have more psychological problems and higher rates of smoking and alcohol consumption. The most frequent complaint was headache and the most common problem in school was denoted as difficulty in concentration. Our study demonstrated that most of the survivors of childhood leukemia are at risk of developing neuropsycological late effects. 相似文献
67.
Halil Özdemir Ergin Çiftçi Rıza Durmaz Haluk Güriz Ahmet Derya Aysev Adem Karbuz Refik Gökdemir Bülent Acar Selin Nar Ötgün Mustafa Ertek Serdal Kenan Köse Erdal İnce 《European journal of pediatrics》2014,173(3):313-320
The aim of this study was to determine serotype distribution and investigate antimicrobial resistance patterns of Streptococcus pneumoniae in healthy Turkish children in the era of community-wide pneumococcal conjugate vaccine (PCV7). The study was conducted on 1,101 healthy children less than 18 years of age. Specimens were collected with nasopharyngeal swabs between April 2011 and June 2011. Penicillin and ceftriaxone susceptibilities were determined by E-test according to the 2008 Clinical Laboratory Standards Institute, and serotypes of the isolates were determined by Quellung reaction. The nasopharyngeal pneumococcal carriage rate was 21.9 % (241/1,101). Using the meningitis criteria of minimum inhibitory concentration values, 73 % of the isolates were resistant to penicillin and 47.7 % of them were resistant to ceftriaxone. Half of all pneumococcal isolates were serotyped as 19F (15.2 %), 6A (15.2 %), 23F (10.3 %), and 6B (9.3 %) and surprisingly, no serotype 19A was isolated. Serotype coverage rates of PCV7 and non-PCV7 were 46.2 and 53.8 %, respectively. The most common penicillin- and ceftriaxone-resistant serotypes were 6A, 6B, 14, 19F, and 23F. Penicillin- and ceftriaxone-resistant isolates were more prevalent in serotypes covered by PCV7 than the non-PCV7 serotypes. Conclusion: After the community-wide PCV7 vaccination, more non-PCV7 serotypes were isolated from the carriers compared to the time before PCV7 was used especially the serotype 6A, and the antimicrobial resistance of pneumococci was significantly increased. 相似文献
68.
Sevgi Akarsu Turna İlknur Emel Fetil Banu Lebe Ali Tahsin Güneş 《Photodermatology, photoimmunology & photomedicine》2010,26(2):101-103
We report on a 35‐year‐old woman with cutaneous lesions characterized by an erythema multiforme‐like appearance localized in the photo‐distributed pattern. She had no history of systemic drug ingestion, herpes simplex virus or any other infection, possible causes of erythema multiforme, before the sun exposure. She had normal tolerance to a phototest, but photoprovocation tests could not be performed because she did not agree to them. This case was diagnosed to be an erythema multiforme‐like variant of a polymorphous light eruption; the differential diagnosis of target‐like lesions in a photo‐distributed pattern is discussed. 相似文献
69.
İlker Durak Hasan Biri İmge B. Ergüder Erdinç Devrim Çağrı Şenocak Aslıhan Avcı 《Medicinal chemistry research》2007,16(6):259-265
Aim Possible effects of garlic (Allium sativum) and black grape (Fructus vitis minuta) with known antioxidant potential on adenosine deaminase (ADA) activities were investigated in cancerous and noncancerous
human bladder tissues.
Methods The effects of garlic and black grape extracts on adenosine deaminase (ADA) activities were measured in 20 pairs of cancer
and adjacent normal human bladder tissues with and without pre-incubation with garlic and black grape extracts at different
concentrations.
Results No significant difference was observed between ADA activities in cancerous and non cancerous bladder tissues without plant
extract (5.85 ± 3.78 versus 7.63 ± 2.88, respectively). At the 1/3 and 1/1 plant extract/bladder tissue homogenate ratios,
the garlic extract completely abolished the ADA activity in both cancerous and noncancerous tissues. At the 1/3 plant extract/bladder
tissue homogenate ratio, the black grape extract decreased the activity significantly as compared to without extract (2.01 ± 1.30
versus 5.85 ± 3.78; p < 0.05 for cancerous tissue and 2.10 ± 1.66 versus 7.63 ± 2.88; p < 0.05 for noncancerous tissue) and, at the 1/1 plant extract/bladder tissue homogenate ratio, completely abolished the activity.
Conclusion Our results show that garlic and black grape have potential to inhibit ADA activity in both cancerous and adjacent normal
human bladder tissues.We suggest that this might be rational basis for the uses of garlic and black grape in the complementary
therapy of urinary bladder cancer. 相似文献
70.
Sandal T 《The oncologist》2002,7(1):73-81
Cancer arises mainly from mutations in somatic cells. However, it is not the result of a single mutation, rather, it results from increasing genetic disarray accumulated over time. Tumorigenesis in humans is, therefore, a multistep and age-dependent process. The multiple mechanisms and multiple players involved in this process necessitate an understanding of the molecular mechanisms, in order to distinctively classify the tumor sample and to assess the risk and treatment of the disease. 相似文献