小针刀疗法结合半夏白术天麻汤治疗椎动脉型颈椎病临床观察

目的:观察3种治疗方法对椎动脉型颈椎病的疗效.方法:将90例推动脉型颈椎病患者随机分为试验组1、试验组2和试验组3各30例,分别治疗1个疗程,对比分析其临床疗效.结果:试验组3疗效(治愈20例,显效8例,无效2例)优于试验组2和试验组1,差异有统计学意义(P＜0.05),并通过两两比较,得出相关结论.结论:小针刀疗法结合半夏白术天麻汤治疗椎动脉型颈椎病疗效更为突出.     

急救仿真模拟人在中医学本科创伤急救教学中的应用

为提高中医专业实习生处理急重症患者的能力,在西医外科创伤急救教学中,引进急救仿真模拟人(emergency care simulator,ECS),开展了模拟重症创伤患者真实情景的临床实习训练,与常规教学组进行了对照评价,并进行了问卷调查。结果显示,ECS培训组学生的理论考试和技能操作成绩均明显优于常规教学组(P<0.05),且学生对ECS教学给予了充分肯定和良好的评价,表明ECS训练教学可提高创伤急救的教学效果,有利于培养学生的临床判断能力和救治能力。     

替吉奥联合奥沙利铂治疗复发、转移性胃癌的临床观察

目的 评估替吉奥(S-1)联合奥沙利铂化疗方案治疗复发、转移性胃癌患者的疗效及不良反应.方法 选择2007年4月至2011 年 6月本院收治的复发、转移性胃癌患者,共 38例,随讥分为替吉奥联合奥沙利铂治疗组(n=19)和顺铂联合氟尿嘧啶对照组(n=19),所有患者均至少接受2个疗程化疗.参照实体瘤疗效评价标准(RECIST),通过治疗后部分缓解(PR)、病情稳定(SD)和病情进展(PD)情况,以及疾病进展时间(TTP)和中位生存时间(MST)等评估疗效,并观察不良反应.结果 治疗组8例为PR,6例为SD,5例为PD,有效率为42.10％,疾病控制率为73.68％,TTP为8.3个月,MST为10.7个月;对照组6例为PR,5例为SD,8例为PD,有效率为31.58％,疾病控制率为57.59％,TPP为7.1个月,MST为8.2个月.西组间有效率、疾病控制率、TTP及MST差异均具有统计学意义(P＜0.05).两组患者主要不良反应为骨髓抑制、胃肠道反应及外周神经毒性,治疗组Ⅲ/Ⅳ级不良反应发生率显著低于对照组(8.5％对17.6％,P＜0.05).结论 替吉奥联合奥沙利铂化疗方案治疗复发、转移性胃癌,临床获益率较高,不良反应较轻,患者耐受良好.     

超声检查在急腹症529例诊断中的应用分析

目的：探讨超声检查在急腹症诊断中的临床价值。方法：分析529例急腹症患者的超声表现并与手术病理、随访结果进行对照。结果：急性胆囊炎297例,内脏外伤68例,泌尿系结石45例,急性胰腺炎28例,胃肠穿孔12例,急性阑尾炎54例,肠梗阻25例,超声诊断符合率分别为98．7％、92．6％、77．8％、78．6％、83．3％、70．4％、92．0％。结论：超声检查在诊断急腹症中起重要作用,为临床提供可靠依据。     

夜爽洗剂的制备及临床疗效观察

目的：研究夜爽洗剂的制备及应用。方法：对夜爽洗剂的制备方法、质量检查、临床应用等方面进行研究。结果：该制热工艺简单,设计合理,稳定性好,疗效确切。结论：夜爽洗剂治疗妇科外阴炎和各种阴道炎等症,效果显著。     

水通道蛋白1在急性坏死性胰腺炎大鼠胰腺组织的表达及其意义

Objective To study the expression of aquaporin 1 ( AQP1 ) in pancreas and its pathogenic role in rats with experimental acute necrotizing pancreatitis (ANP). Methods Forty-eight male Sprague-Dawley rats were randomly divided into two groups : control group ( n = 24 ) and ANP group ( n = 24). Six rats in each group were sacrificed at 3,6,12 and 18 h after induction of experimental models. Quantity of ascites and levels of serum amylases were measured at each time point. Serum AQPI was determined by ELISA. Pathological changes of pancreatic tissues were examined. Capillary permeability in pancreatic tissues was tested by Evans Blue (EB) extravasation method. AQPI expression in pancreatic tissues was detected by immunohistochemieal staining, Western blot and fluorescence quantitative polymerase chain reaction (FQ-PCR). Results (1) Serum amylase level at 3,6,12, and 18 h in control group was (1308±759) ,(1077±508), (1325±761),(1328±762) U/L,and that in ANP group was (9102± 2199), (8799±1634), (9398±1473), (9484±862) U/L respectively. The concentration of EB in pancreatic tissues at each time point in control group was (205.61±32.99), (141.46±27.18 ), (96.94± 26.79), (61.43±24.82) mg/L, and that in ANP group was ( 273.59±23.47 ), ( 253.51±31.68 ), (221.15±73.68 ), (185.28±42.35) ,respectively. There was significandy difference between two groups. Serum AQP1 level in control group at each point was ( 74.08±11.80), (78.49±9.06 ), (75.77± 7.37 ), ( 72.75±13.87 ) mg/L, and that in AN P group was (73.29±9.61 ), ( 62.85±7.28 ), (62.07± 4.39 ), (46.33±11.91 ) mg/L, respectively ( P < 0.01 ). ( 2 ) Protein expression of AQPI in pancreatic tissues detected by immunohistochemical staining in control group at each time point was 114.13±7.92, 122.39±7.99,145.98±6.48,113.98±6.48, and that in ANP group was 80.07±14.89,110.54± 4.45,103.77±10.48,99.18±6.95;Protein expression of AQP1 in pancreatic tissues detected by Western blot in control group at each time point was 1.19±0.33,1.02±0.25,0.90±0.33,1.06±0.20,and that in ANP group was 0.83±0.11,0.96±0.21,0. 58±0.28,0.72±0.14, respectively ( P < 0.05 ). ( 3 ) The mRNA level of AQP1 gene expressed in pancreas in control group at each time point was 0.91±0.22,1.01±0.83,0.48±0.23,0.61±0.51,and that in ANP group was 2.13±0.63,2.02±1.40, 2.07±0.86,2.49±2.47,respectively (P<0.01).Condusion The expression of AQP1 wasdown-reg-ulated in pancreas in rats with ANP,which might could play an important role in the pathogenesis of capil-lary leak syndrome.     

奉贤区食品生产经营单位法制培训效果探讨

对奉贤区内 5 0 0户的食品生产经营单位进行抽样调查 ,其目的是了解单位负责人卫生法律法规知识培训前后的效果。结果表明 ,他们培训前后在卫生法律法规执行情况、卫生态度、行为等方面都有着明显差异。     

大肠癌病人血清B因子水平的变化

恶性肿瘤病人血清中许多补体成份,特别是有关补体替代激活途径的一些指标是增高的。B因子是补体替代激活途径中的重要成份。我们采用由我院临床实验中心制备的B因子抗血清,以速率散射比浊测定法在Beckman公司生产的Array ~(IM)Protein System上自动测定了13例大肠癌(肿瘤组:男10组,女3组:21～73岁,平均55.00岁)和12例非肿瘤志愿者(对照组:男9例,女3例:23～73岁,平均49.33岁)的血清B因子浓度。对大肠癌手术标本行常规病理检查,以Astler-Coller修正的Dukes分期法对大肠癌病人进行分