全文获取类型
收费全文 | 39638篇 |
免费 | 4320篇 |
国内免费 | 2745篇 |
学科分类
医药卫生 | 46703篇 |
出版年
2024年 | 114篇 |
2023年 | 690篇 |
2022年 | 1286篇 |
2021年 | 2314篇 |
2020年 | 1704篇 |
2019年 | 1468篇 |
2018年 | 1506篇 |
2017年 | 1361篇 |
2016年 | 1267篇 |
2015年 | 1910篇 |
2014年 | 2395篇 |
2013年 | 2232篇 |
2012年 | 3105篇 |
2011年 | 3397篇 |
2010年 | 2172篇 |
2009年 | 1828篇 |
2008年 | 2202篇 |
2007年 | 2187篇 |
2006年 | 2171篇 |
2005年 | 1847篇 |
2004年 | 1336篇 |
2003年 | 1149篇 |
2002年 | 961篇 |
2001年 | 839篇 |
2000年 | 795篇 |
1999年 | 822篇 |
1998年 | 527篇 |
1997年 | 482篇 |
1996年 | 376篇 |
1995年 | 325篇 |
1994年 | 330篇 |
1993年 | 191篇 |
1992年 | 238篇 |
1991年 | 189篇 |
1990年 | 157篇 |
1989年 | 196篇 |
1988年 | 136篇 |
1987年 | 133篇 |
1986年 | 62篇 |
1985年 | 71篇 |
1984年 | 46篇 |
1983年 | 30篇 |
1982年 | 26篇 |
1981年 | 26篇 |
1980年 | 18篇 |
1979年 | 25篇 |
1978年 | 11篇 |
1975年 | 8篇 |
1974年 | 10篇 |
1973年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 343 毫秒
101.
精索扭转误诊24例分析 总被引:5,自引:0,他引:5
目的:分析精索扭转误诊的原因及教训,提高临床医生对该病的认识水平与警惕性,以减少误诊的发生。方法:对24例外院误诊的精索扭转病例进行回顾性分析。结果:24例患者均经手术证实为精索扭转,因未能及时诊断,延误时机而切除缺血坏死的睾丸。结论:彩色多普勒血流动态显像应作为诊断该疾病的常规与首选检查方法,对精索扭转一旦确诊或疑有精索扭转的患者应及早行紧急复位,以期挽救睾丸。同时行睾丸固定术也十分必要,对于确诊毫无保留价值的睾丸需行切除。 相似文献
102.
本文将聚乙二醇(PEG)比浊法和固相酶联免疫法(ELISA)结合,建立了—较灵敏的免疫复合物(IC)直接固相吸附抗原特异性检测法。利用牛清蛋白(BSA)为已知抗原组份的IC模型,分别对IC直接固相吸附的条件和影响因素、方法的灵敏度、重复性等进行了研究。结果发现IC在解离状态下直接固相吸附后的抗原特异性检测灵敏度明显高于未解离者。该法具有简单易行,灵敏度较高、适于临床测定大量血清样品等优点。 相似文献
103.
目的探讨肾动脉狭窄支架植入术的临床疗效.方法1997年1月~2004年12月,我院行支架介入治疗肾动脉狭窄27例.对27例术前、术后及随访期内血压、肾功能以及生活质量进行评估,并与同期单纯药物治疗肾动脉狭窄27例进行比较.结果介入组27例植入支架40枚,手术成功24例(88.9%,24/27),失败3例(11.1%,3/27),手术并发症5例(18.5%,5/27).术后在血压下降(包括收缩压舒张压)肌酐下降,肾小球滤过率增加方面,介入组获益率明显优于药物组,两组比较差异均有显著性,术后随访6个月~8年6个月,中位数为1年9个月,介入组有19例能比较健康的生活和工作,药物组仅12例能维持生活和工作.结论支架介入治疗较单纯药物治疗肾动脉狭窄疗效显著. 相似文献
104.
Fan Gao Mark L Latash Vladimir M Zatsiorsky 《Journal of hand therapy》2007,20(4):300-7; quiz 308; discussion 309
The tight coupling between load (L) and grip (G) forces during voluntary manipulation of a hand-held object is well established. The current study is to examine grip-load force coupling when motion of the hand with an object was either self-generated (voluntary) or externally generated. Subjects performed similar cyclic movements of different loads at various frequencies with three types of manipulations: 1) voluntary oscillation, 2) oscillating the right arm via the pulley system by the left leg (self-driven oscillation), and 3) oscillating the arm via the pulley system by another person (other-driven oscillation). During the self-generated movements: 1) the grip forces were larger and 2) grip-load force modulation was more pronounced than in the externally generated movements. The G-L adjustments are not completely determined by the mechanics of object motion; nonmechanical factors related to movement performance, for instance perceptual factors, may affect the G-L coupling. 相似文献
105.
106.
目的 评价血管紧张素Ⅱ、氨甲酰血红蛋白、醛固酮及甲状旁腺激素等在血液净化充分性中的意义。方法 120例慢性肾功能衰竭患者,按采用不同的透析膜分为3组:即聚砜膜、醋酸膜、铜仿膜。用放射免疫法测定其血管紧张素Ⅱ(AngⅡ)及醛固酮(ALD)浓度,化学发光法测甲状旁腺激素(PTH)。采用不同的血流量200ml/min及250ml/min比较。结果 对体内中、小分子物质清除率,聚砜膜〉醋酸膜〉铜仿膜。结论 高血流量、高通透性人工合成聚砜膜,对治疗慢性肾功能衰竭,提高肾功能不全患者的身心健康及生活质量、延长患者生命有很重要的临床意义。 相似文献
107.
Fat-Derived Hormone Adiponectin Combined with FTY720 Significantly Improves Small-for-Size Fatty Liver Graft Survival 总被引:1,自引:0,他引:1
K. Man Y. Zhao A. Xu C.M. Lo K.S.L. Lam K.T. Ng J.W.Y. Ho C.K. Sun T.K. Lee X.L. Li S.T. Fan 《American journal of transplantation》2006,6(3):467-476
Owing to the discrepancy between organ donation and the demand for liver transplantation, expanding the liver donor pool is of vital importance. However, marginal liver grafts, such as small-for-size and/or fatty grafts, were associated with primary graft nonfunction or poor function. Therefore, novel combination therapies to rescue small-for-size fatty liver grafts should be investigated. In this study, we applied a combination therapy using a fat-derived hormone adiponectin (anti-steatosis) plus immunomodulator FTY720 (anti-inflammatory) in a rat liver transplantation model using small-for-size fatty liver grafts, and investigated the underlying protective mechanism such as anti-steatosis, intra-graft energy metabolism, hepatic microcirculatory changes, cell signaling cascades for survival, apoptosis and inflammation. The current study demonstrated that even a single treatment of adiponectin or FTY720 improved the 7-day graft survival from 0% to 62.5% (p = 0.001). The combination therapy significantly increased the 7-day graft survival rate to 100% by remarkable attenuation of graft steatosis and acute phase inflammatory response, significant activation of cell survival Akt pathway and maintenance of intra-graft adenosine triphosphate metabolism and improvement of hepatic microcirculation. In conclusion, the fat-derived hormone adiponectin combined with FTY720 might be a novel combination drug therapy for prevention of small-for-size fatty liver graft injury. 相似文献
108.
109.
110.
Yu-Yan Fan Ryoko Baba Yukiko Nagai Akira Miyatake Naohisa Hosomi Shoji Kimura Guang-Ping Sun Masakazu Kohno Mamoru Fujita Youichi Abe Akira Nishiyama 《Hypertension research》2006,29(3):169-178
Recent studies have suggested that aldosterone plays a role in the pathogenesis of renal injury. In this study, we investigated whether local angiotensin II (Ang II) activity contributes to the progression of renal injury in aldosterone/salt-induced hypertensive rats. Uninephrectomized rats were treated with 1% NaCl in a drinking solution and one of the following combinations for 6 weeks: vehicle (2% ethanol, s.c.; n=9), aldosterone (0.75 mug/h, s.c.; n=8), aldosterone+Ang II type 1 receptor blocker olmesartan (10 mg/kg/day, p.o.; n=8), or aldosterone+olmesartan (100 mg/kg/day, p.o.; n=9). Aldosterone/salt-treated hypertensive rats exhibited severe proteinuria and renal injury characterized by glomerular sclerosis and tubulointerstitial fibrosis. Aldosterone/salt-induced renal injury was associated with augmented expression of angiotensin converting enzyme and Ang II levels in the renal cortex and medullary tissues. Renal cortical and medullary mRNA expression of transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) as well as the collagen contents were increased in aldosterone/salt-treated hypertensive rats. Treatment with olmesartan (10 or 100 mg/kg/day) had no effect on blood pressure but attenuated proteinuria in a dose-dependent manner. Olmesartan at 10 mg/kg/day tended to decrease renal cortical and medullary Ang II levels, TGF-beta and CTGF expression, and collagen contents; however, these changes were not significant. On the other hand, an ultrahigh dose of olmesartan (100 mg/kg/day) significantly decreased these values and ameliorated renal injury. These data suggest that augmented local Ang II activity contributes, at least partially, to the progression of aldosterone/salt-dependent renal injury. 相似文献