EFFECT OF INTRA-ARTICULAR FRACTURE ON ARTICULAR CHONDROCYTES A TRANSMISSION ELECTRON MICROSCOPIC STUDY

Intra-articular fractures involving the subchondral bone were produced surgically in both left and right medial femoral condyles of twenty rabbits. The edges of the fractures on the left side were well approximated, while those on the right side maintained with a gap of 2 mm. Transmission electron microscopic study of the nearby articular cartilages conducted 1, 2, 3, 4 and 5 months after the fracture revealed the following results: 1) The neighbouring articular chondrocytes tended once to assume the configuration of fibroblasts; 2) Those remote from the fracture showed both degeneration and hyperplasia to form clones; 3) Even after the intra-articular fractures were well-healed, degeneration and hyperplasia of the articular chondrocytes nearby the fracture would persist for some time.     

ULTRASTRUCTURAL INVESTJGATION ON EXPERIMENTAL FRACTURE HEALING V. ELECTRON MICROSCOPIC OBSERVATION ON CAPILLARY FORMATION

In the early period of repair following a standardized fracture of the radius of rabbits, ca- pillary formation can be seen in five different callus regions. The capillaries may be formed from a single endothelial ceH, or conjointly by two or more endothelial cells. When the endothelial cells con- tacted with each other, the cell membranes may be intimately joined together or form a cleft to fa- cilitate the passage of water, while in some cases a membranous flap may be formed, extending into the capillary lumen. There are pericytes surrounding and abutting on the capillaries. Both capillaries and pericytes are invested by a basal Iamina.     

ULTRASTRUCTURAL INVESTIGATION OF EXPERIMENTAL FRACTIJRE HEALING L* ELECTRON MICROSCOPIC OBSERVATION OF CELLULAR ACTIVITY

Cellular activity in rabbit radius fractures is studied and observed by elcctron micro- scope. After fract,urc, polymorphonuclear neu- trophils, macrophages, fibrobIasts, chondroblasts and osteoblasts and osteoeytes appear at the fracture site in suc.cession. They represenL Lhe folloiving stages of fraet,ure healing: inflamma- tory stage, debridement stage, fibrous caUus stage, primary bony callus stage and secondary bony callus stage. Fibroblasts particjpate in and possess the action of osteagcnesis.     

儿童股骨干骨折后的下肢不等长

下肢不等长是儿童股骨干骨折治疗的最常见并发症。这是股骨在其长轴过分生长所引起的结果,是由于愈合过程中的充血所致,而并非由于代偿性的机。病人的大脑支配则在这方面只有很小的影响。股骨骨折的解剖复位内固定可导致肢体生长过度。因而这种处理只适用于短下肢的病儿或多发性骨折的病儿。如矫形外科医师能预期以后股骨的生长过度,则在股骨骨折愈合以前允许骨端的适度重叠,不同的作者推荐不同程     

前列腺素E2防止废用性骨质疏松症

大鼠右后肢经弹力绷带固定于腹部后,分别给于不同时期、不同剂量的前列腺素E_2(PGE_2)治疗。与年龄对照组及固定不治疗组相比,PGE_2虽然引起松质骨的侵蚀以及皮质骨的稀疏,但却能刺激编织骨及板层骨形成及骨外膜、骨内膜新骨形成。因之,PGE_2可以防止废用性骨丢失。     

全髋置换术后假体松动界膜的超微结构研究──成纤维细胞的退变与功能紊乱

全髋置换术后假体松动界膜的超微结构研究成纤维细胞的退变与功能紊乱饶寒敏汤雪明柴本甫杨庆铭李慧通过对构成假体周围界膜的主要细胞成份成纤维细胞的超微结构分析与研究，为进一步探索假体松动的成因与防治措施提供细胞学基础。一、材料与方法因骨关节炎、股骨头缺血性...     

OSTEOCLASTIC RESORPTION OF HAVERSIAN SYSTEMS IN CORTICAL BONE OF FEMORAL NECK IN AGED WOMEN A SCANNING ELECTRON MICROSCOPIC S

ＯＳＴＥＯＣＬＡＳＴＩＣＲＥＳＯＲＰＴＩＯＮＯＦＨＡＶＥＲＳＩＡＮＳＹＳＴＥＭＳＩＮＣＯＲＴＩＣＡＬＢＯＮＥＯＦＦＥＭＯＲＡＬＮＥＣＫＩＮＡＧＥＤＷＯＭＥＮＡＳＣＡＮＮＩＮＧＥＬＥＣＴＲＯＮＭＩＣＲＯＳＣＯＰＩＣＳＴＵＤＹＣｈａｉＢｅｎｆｕ柴本甫，Ｔ...     

血小板源性生长因子加强软骨及骨形成

在动物皮下组织内植入脱钙骨基质可诱导骨形成,并可部分摹拟骨发育。经过短暂的炎性反应以后,间充质干细胞通过趋化性而进入植入区,并在第3天开始增殖。间充质细胞于第5～7天分化为软骨细胞,第9～12天分化为骨细胞。最后于第21天分化为生血的骨髓。     

固定对关节的影响

固定是治疗肌肉骨骼系统疾病的一种最常用的方法,但可产生各种不良后果,包括慢性水肿、肌肉萎缩、关节强硬及废用性骨质疏松。这些后果有其形态学、生物力学及生物化学方面的原因。形态学方面的变化如将大鼠膝关节进行固定,在最初2周内关节四周的肌肉发生萎缩,并伴有关节内纤维脂肪结缔组织的增殖。增殖的纤维脂肪结缔组织逐渐长入关节腔内,固定30天时可封闭正常的滑膜缝隙,由于固定而压缩、接触的关节软骨逐渐变薄并发生萎     

消炎痛、阿斯匹林及布洛芬对人工假体微孔涂层内骨长入的影响

新骨长入家兔股骨内人工假体的微孔涂层后,就可以为假体提供一个生物的固定。绝大多数进行人工假体植入术的医师希望有更多新生骨组织长入假体表面的微孔涂层内。影响新骨长入微孔涂层内的条件,可以最终引起无骨水泥关节成形术的失败。消炎痛、布洛芬及阿斯匹林可以抑制动物与人的异位骨形成,也可以抑制骨折愈合及骨改建。本研究的目的是探