血液透析串联血液灌流联合抢救重症药物中毒

以往抢救药物中毒,单纯采用洗胃和内科对症治疗,往往疗效不佳。血液透析治疗是根据扩散和渗透机理清除血液中游离的小分子毒物,血液透析不仅能纠正体内的电解质紊乱和酸碱平衡,而且能够利用跨膜压达到脱水的目的。而灌流器具有吸附性强和吸附谱广,以及血液相容性良好的特点,可以清除血液中的大、中、小分子物质。所以自1992年8月至2002年12月,我院抢救氯丙嗪、氯氮平、鲁米钠、雷米封、氯硝安定等重症药物中毒共48例,25例采取优势互补,经用血液透析串联血液灌流治疗后,在改善心肺水肿和酸碱平衡上疗效明显好于灌流组。1材料与方法1.1一般资…     

儿童肱骨上尺挠骨下骨折的治疗

目的 探讨儿童肱骨髁上骨折合并同例尺挠骨下1/4双骨折进行保守治疗可行性。方法 本组32例患者均采用手法复位石膏外固定的治疗方法。结果 全部愈合，优良率达93．6％。结论 儿童肱骨髁骨折合并同例尺挠骨1/4双骨折是一种较严重的损伤，其确切发生率不详，采用复位石膏外固定的保守疗法治疗此类骨折，是一种较好的治疗方法。     

手法推拿针刺艾炙治疗腰椎间盘突出症

腰椎间盘突出症是临床中常见病和多发病 ,腰痛、坐骨神经痛是其主要的临床特征 ,属中医“腰腿痛”范畴。我们采用手法推拿、针刺、艾炙治疗腰椎间盘突出症100例 ,取得了较满意的疗效。现报道如下 :1临床资料1 1一般资料 :本组100例均为门诊患者 ,其中男71例 ,女29例 ,年龄26～78岁 ,以29～56岁居多 ,体力劳动58例 ,非体力劳动10例 ,有腰部外伤史22例 ,受寒凉而复发10例。病程1天～6年 ,严重者不能行走 ,生活难以自理。1 2诊断要点 :(1)腰痛伴坐骨神经痛 ,沿臀部大腿 ,后侧及小腿外侧至足部放射痛 ,急性发作时疼痛难忍 ,夜不能寝 ,咳嗽、喷嚏…     

川红花产地环境及品质特性研究

川红花是传统的活血化瘀中药材,本文从川红花道地产区简阳的产地生态环境、产区的种植历史、与其它品种质量的比较等多方面研究了川红花的品质特性。结果表明,简阳具有悠久的川红花种植历史,良好的种植技术和品牌效应,产地生态环境因子（大气、土壤、农田灌溉、水质）符合中药材生产质量管理规范（GAP）要求;川红花品种的有效成份黄色素和红色素含量高,其吸收度分别为0.614和0.844,符合《中国药典》2000年版一部要求,并高于其它同生态条件种植的非地道性品种,其水溶性黄酮苷类的含量也高于其它品种;在不影响黄色素和黄酮苷类含量的条件下改进采收加工技术可大幅度提高红色素的含量,吸收度可达1.271,对红色素工业化提取极有利用价值;川红花药材的主要重金属和农药残留量均明显低于国家药材进出口绿色行业标准。实施川红花规范化栽培及按GAP要求建立生产基地后将进一步提高川红花的品质,增强川红花的国际市场竟争能力。     

转染CD40配体的卵巢癌细胞株OVHM抗卵巢癌肝转移机制的研究

Objective To examine the in vivo anti-metastatic effect of enhanced expression of CD40L cDNA in murinc ovarian cancer OVUM cells (CD4OL-OVHM) injected into the spleen on liver metastasis in mice. Methods OVUM cells were inoculated into the spleen of 6 ～ 8 week-old female B6C3F1 (C57BL/6N × C3H/He) mice. The established liver metastasis was identified by histopathology (HE staining). OVUM cells, DNA-pMKITneo-OVHM cells or CD40L-OVHM cells were inoculated into the spleen of female B6C3F1 mice and the expressions of CD11c in splenic cells were detected by flow cytometry. The specific cytotoxicity of splenic cells was detected by MTT assay, and the serum cytokines of IFN-γ, TNF-α, IL-12, IL4 and IL-10 of the mice were measured by enzyme linked immunoabsorbent assay. The liver metastases and the survival time of the mice were also recorded. Results The mouse models with liver metastasis by injecting tumor cells into the spleen of mice were established. The expression of CD11c and the specific killing rote in CD40L-OVHM cells group was significantly higher than that in the OVHM cells group and DNA-pMKITneo-OVHM cells group. The expressions of IFN-γ, TNF-α and IL-12 in the CD40L-OVHM cells group were much more increased than OVHM cells group and DNA-pMKITneo-OVHM cells group, but the expressions of IL-4 and IL-10 in the CD40L-OVHM cells group were decreased significantly (P < 0.05). The average weights of livers and spleens of mice in CD40L-OVHM cells group were significantly lower than those of DNA-pMKITneo-OVHM cells group and OVHM cells group. The survival time of mice in CD40L-OVHM cells group was also significantly longer than that in the OVHM cells group and DNA-pMKITneo-OVHM cells group (P < 0.05). Conclusion The data directly demonstrate that the expression of CD40L in ovarian cancer cells (CD40L-OVHM) can enhance the proliferation and differentiation of dendritic cells in the spleen and induce specific cytotoxic effect of T cells in the spleen, and may regulate the immune function of peripheral blood cells and the immune balance between Thl cells and Th2 cells, which maybe the possible mechanism induced by CD40L in mice inhibiting the development of liver metastasis.     

六味地黄丸加味治疗老年性便秘56例

采用六味地黄丸辨证加减治疗老年性便秘56例,总有效率92.86％,且疗效与患者的年龄和病程均有一定的相关性。提示本方通过滋补肾阴、肾阳,以增强生津润肠通便之功。     

中西医结合治疗肝硬化腹水46例疗效观察

目的:观察中西医结合治疗肝硬化腹水的临床疗效。方法:将78例肝硬化腹水患者随机分为治疗组46例,对照组32例。2组均采用利尿西药治疗,治疗组加服益气养阴,健脾利水为主兼以活血软肝理气之中药,1个月为1个疗程,治疗2个疗程。结果:治疗组显效32例,有效12例,总有效率为95%;对照组显效13例,有效11例,总有效率为75%,2组比较,差异有显著性意义(P<0.05)。结论:中西医结合治疗肝硬化腹水疗效优于单纯西药治疗。     

SARS暴发流行与气象条件关系的分析

本文利用北京、广州、太原和长沙四地SARS病例资料和前期及同期气象资料进行了时间相关、地域对比分析，结果显示：当最低气温、平均气温较低和空气干燥(湿度小)时，预示后期发病人数有较大增加；反之，当最低气温、平均气温较高和空气潮湿(湿度大)时，预示后期发病人数有较大减少。此外每次降温过程的出现预示着SARS发病人数将增加。     

激光治疗阻塞性睡眠呼吸暂停低通气综合征疗效评价

目的：探讨Nd：YAG激光治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的疗效。方法：对89例OSAHS患者行激光悬雍垂腭咽成形术(LAUP)．手术切除部分软腭及悬雍垂，在悬雍垂两侧向上楔形打开软腭。结果：术后6个月复查有76例行多导睡眠监测，治愈8例，显效36例，有效25例，无效7例，总有效率90．8％。结论：Nd：YAG激光具有止血凝固作用且穿透力强，手术视野清晰，并发症少，可缩短手术时间。LAUP治疗OSAHS效果良好。     

不同产地胡芦巴中总黄酮和槲皮素的含量测定

目的测定胡芦巴 (Trigonellafoenum graecumL )种子中总黄酮及槲皮素的含量。 方法总黄酮含量测定 :以芦丁为对照品 ,采用分光光度法 ,于 5 10nm处测定 ;槲皮素含量测定 :采用高效液相色谱法 ,色谱柱为KromasilODS— 1,流动相为乙腈 1g·L-1磷酸溶液 (体积比 30∶70 ) ,检测波长 36 0nm。结果总黄酮在 8 4 8～ 5 0 88mg·L-1(r =0 9996 )、槲皮素在 0 18～ 3 6 8mg·L-1(r =0 9995 )内线性关系良好 ;总黄酮和槲皮素的平均回收率分别为 99 4 %、99 3%。结论建立的方法可为胡芦巴的质量控制提供依据