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71.
Importance of specimen size in accurate needle liver biopsy evaluation of patients with chronic hepatitis C. 总被引:1,自引:0,他引:1
Thomas D Schiano Samia Azeem Carol A Bodian Henry C Bodenheimer Sukma Merati Swan N Thung Prodromos Hytiroglou 《Clinical gastroenterology and hepatology》2005,3(9):930-935
BACKGROUND & AIMS: In patients with chronic hepatitis C (CHC), percutaneous needle liver biopsy examination establishes the severity of necroinflammatory activity and fibrosis, thus guiding treatment decisions. Optimal biopsy specimen size remains controversial. We sought to determine how varying lengths of biopsy specimens influence the grading and staging of CHC. METHODS: We used 100 liver biopsy specimens from patients with CHC. The slides were evaluated blindly using the METAVIR scoring system, after being covered with paper, so that only specific specimen lengths (5 mm, 10 mm, 15 mm, and > or =20 mm) were visible. In each case, the scores obtained with biopsies 5 mm, 10 mm, or 15 mm long were compared with the scores at 20 mm or greater by weighted kappa statistics (kappa of >.75 signified excellent agreement). A subset of specimens 20 mm or greater was selected for a blinded repeat scoring to assess intraobserver agreement. The kappa statistics for the designated features and lengths were compared using analysis of variance. RESULTS: In assessing the stage of fibrosis, the weighted kappa statistics for agreement with the 20-mm or greater score at 5 mm, 10 mm, and 15 mm were .75, .85, and .92, respectively. In assessing the histologic activity score, the corresponding figures were .73, .81, and .77, respectively. Average kappa statistic comparisons showed that intraobserver agreement was significantly better than agreement between the 20-mm or greater scores and those at shorter lengths; the 5-mm kappa scores were significantly lower than the others; and there was no significant difference between the 10-mm and 15-mm kappa scores. CONCLUSIONS: Liver biopsy specimens measuring at least 10 mm usually reflect the grade and stage of CHC reliably. Relatively little improvement in diagnostic accuracy is obtained with longer specimens. 相似文献
72.
Jeri A. Logemann Ph.D. Peter J. Kahrilas M.D. Peter Hurst D.D.S. John Davis D.D.S. Christine Krugler B.A. 《Dysphagia》1989,4(2):118-120
The swallowing patterns of four patients with oral cancer with intraoral palate reshaping/lowering prostheses were studied
with and without their prostheses 3 months postoperatively. The prostheses resulted in improved swallow efficiency, increased
duration of tongue contact to the pharyngeal wall, and improved speed of movement of the bolus from the valleculae to the
pyriform sinus. These results emphasize the effects of the tongue on the pharyngeal as well as oral stage of the swallow. 相似文献
73.
E R McRorie P McLoughlin T Russell I Beggs G Nuki N P Hurst 《Annals of the rheumatic diseases》1996,55(2):99-104
OBJECTIVES: To review the outcome of surgery undertaken to stabilise the neck in patients with rheumatoid arthritis performed over a five year period, to compare the results with those of previous reports, and to identify factors that may predict surgical outcome. METHODS: Outcome was assessed at time of discharge from hospital after surgery by review of patients' notes, and at follow up by patient interview, clinical examination, anonymous questionnaire, and cervical spine radiograph. The Ranawat classification of neurological impairment and Steinbrocker functional classification were used. RESULTS: Thirty nine patients underwent 44 procedures; 28 patients were available for review after a mean period of 29.8 months (range 12-65 months). Fourteen patients had preoperative neurological impairment and were available for follow up; 13 returned the questionnaire. Four (29%) had improved Ranawat class, nine were unchanged, and one had deteriorated. Nine (69%) reported a subjective improvement in neurological symptoms by questionnaire, even though the Ranawat class was unchanged in five. Twenty five of the patients reviewed had pain before operation; 21 returned the questionnaire. Pain relief was reported by direct questioning and questionnaire in 76% and 67% of patients, respectively. Overall, 67% felt that surgery had been successful. Surgery was more successful in producing symptomatic relief in patients with neck or radicular pain than in those with neurological deficit, but did prevent progression of neurological symptoms. CONCLUSIONS: Our results are similar to those from other centres. Overall patient satisfaction with surgery was good. Surgery was more likely to produce symptomatic relief in patients with neck or radicular pain before operation than in those with neurological deficit. The greater subjective improvement in neurological symptoms as judged by questionnaire probably reflects the relative insensitivity of the Ranawat classification in detecting change in neurological status; previous reports of poor outcome for patients with neurological symptoms who undergo surgery may in part be a reflection of the insensitivity of this method of assessment. No clear factors emerged which allowed prediction of those patients at greatest risk of operative mortality. In particular, an increased risk of neurological compromise appeared to confer no additional risk of immediate perioperative death. Our data support the suggestion that early surgery to correct symptomatic atlantoaxial subluxation may prevent progression of instability. 相似文献
74.
Dr. Robert M. Rose M.D. Dr. Michael W. Hurst Ed.D. 《Behavioral medicine (Washington, D.C.)》2013,39(1):22-36
Abstract Plasma Cortisol and growth hormone (HGH) responses to venous catheterization were studied in 29 volunteer subjects. Repeat catheterizations were performed in 18 individuals. Mean plasma cortisol levels were significantly elevated during the first hour of the initial catheterization experience. Morning and afternoon levels of cortisol were not distinguishable during the first catheterization, but PM levels were significantly lower than AM levels during the second catheterization experience. Growth hormone responses were much more variable than cortisol and were distributed logarithmically. Growth hormone responses tended to parallel cortisol responses during the first catheterization experience. Individuals who listed more symptoms in response to venipuncture and catheterization after finishing their first catheterization had significantly higher cortisol and growth hormone levels during this experience. These data suggest a definite endocrine adaptation to catheterization by the second or third hour of the experience. 相似文献
75.
Efficacy of different modes of fractional CO2 laser in the treatment of primary cutaneous amyloidosis: A randomized clinical trial
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Samia M. Esmat MD Marwa M. Fawzi MD Heba I. Gawdat MD Heba S. Ali Safinaz S. Sayed MD 《Lasers in surgery and medicine》2015,47(5):388-395
Background
Primary cutaneous amyloidosis (PCA) comprises three main forms: macular, lichen, and nodular amyloidosis. The current available treatments are quite disappointing.Objectives
Assess and compare the clinical and histological changes induced by different modes of Fractional CO2 laser in treatment of PCA.Patients and Methods
Twenty five patients with PCA (16 macular and 9 lichen amyloidosis) were treated by fractional CO2 using; superficial ablation (area A ) and deep rejuvenation (area B ). Each patient received 4 sessions with 4 weeks intervals. Skin biopsies were obtained from all patients at baseline and one month after the last session. Patients were assessed clinically and histologically (Congo red staining, polarized light). Patients were followed‐up for 3 months after treatment.Results
Both modes yielded significant reduction of pigmentation, thickness, itching, and amyloid deposits (P‐value < 0.001). However, the percentage of reduction of pigmentation was significantly higher in area A (P‐value = 0.003). Pain was significantly higher in area B. Significant reduction in dermal amyloid deposits denotes their trans‐epidermal elimination induced by fractional photothermolysis.Conclusion
Both superficial and deep modes of fractional CO2 laser showed comparable efficacy in treatment of PCA. Superficial mode being better tolerated by patients, is recommended as a valid therapeutic option. Lasers Surg. Med. 47:388–395, 2015. © 2015 Wiley Periodicals, Inc. 相似文献76.
77.
David M. Hurst Matthew E. Oster Sherry Smith Martha L. Clabby 《Pediatric cardiology》2015,36(7):1382-1385
78.
Cardiopulmonary effects of traditional Thai dance on menopausal women: a
randomized controlled trial
Taweesak Janyacharoen Chonticha Phusririt Sariya Angkapattamakul Cameron P. Hurst Kittisak Sawanyawisuth 《Journal of Physical Therapy Science》2015,27(8):2569-2572
[Purpose] This study evaluated the effects of Thai dance on cardiopulmonary factors in
menopausal women. [Subjects] Sixty-six menopausal women aged 40 years or more. [Methods]
Subjects were randomly assigned to either the Thai dance or control group. The Thai dance
group performed a traditional Thai dancing exercise program for 60 minutes, 3 times per
week for 6 weeks. The control group received general health guidance. The 6-minutewalk
test, peak expiratory flow, forced vital capacity, forced expiratory volume in one second,
maximal voluntary ventilation, and chest expansion were assessed at baseline and at the
end of the study. [Results] Sixty-six menopausal women were eligible. At the end of the
study, all variables were significantly better in the Thai dance group than the control
group. Moreover, all variables improved significantly compared to baseline in the Thai
dance group but not in the control group. For example, the mean 6-minutewalk test result
in Thai dance group at the end of the study was 285.4 m, which was significantly higher
than that at baseline (254.8 m) and the control group at baseline (247.0 m). [Conclusion]
A 6-week Thai dance program improves cardiorespiratory endurance in menopausal women.Key words: Exercise, Cardiorespiratory endurance, Lung function 相似文献
79.
Panupong Jiamsripong Tadaaki Honda Christina S Reuss R Todd Hurst Hari P Chaliki Diane E Grill Stephen L Schneck Rochelle Tyler Bijoy K Khandheria Steven J Lester 《European journal of echocardiography》2008,9(3):351-355
AIM: To compare and contrast 3 different echocardiographic methods used to measure left atrial (LA) volume: biplane area length (AL), biplane modified Simpson (SIMP), and prolate ellipse (PE) methods. METHODS AND RESULTS: A review of consecutive patients who presented to our outpatient echocardiography laboratory for a resting transthoracic study between April 2006 and May 2006 was performed. Echocardiograms were reexamined and LA volume measured using the AL, SIMP, and PE methods. Of 102 consecutive patients evaluated, 97 had a measure of LA volume using all 3 methods. A significant difference in the measurement of mean +/- SD LA volume was noted among the 3 different methods: 37 +/- 16 mL/m(2) for AL, 34 +/- 14 mL/m(2) for SIMP, and 27 +/- 12 mL/m(2) for PE. The PE method yielded routinely smaller values compared with either the AL or SIMP method (P < 0.001). Differences increased with increased LA volume. The SIMP method derived consistently smaller (<5 mL/m(2)) values than those of the AL method, consistent across the full range of LA volumes. CONCLUSION: Significant differences exist among these 3 commonly used methods for measuring LA volume. Standardization of the measurement of LA volume is recommended. 相似文献
80.
Iman A Abdelgawad Rawya H El-Mously Magdy M Saber Ossama A Mansour Samia A Shouman 《International journal of clinical and experimental pathology》2015,8(4):4074-4082
Vitamin D and calcium are involved in a wide range of proliferation, apoptosis and cell signaling activities in the body. Suboptimal concentrations may lead to cancer development. The role of phosphate in cancer metabolism is particularly relevant in breast cancer while, magnesium deficiency favors DNA mutations leading to carcinogenesis. Objectives: To determine serum levels of vitamin D, calcium, phosphorus, magnesium, and parathormone in female breast cancer patients and to assess their association with some prognostic factors in breast cancer. Design and methods: This study is done on 98 newly diagnosed female breast cancer patients and 49 age matched apparently healthy female volunteers as controls. Serum samples from all patients and controls were subjected to 25-OH Vit D, calcium, phosphorus, magnesium, and parathormone measurements. Results: In the breast cancer group, the median serum levels of 25-OH Vit D were 15 ng/ml, while it was 21 ng/ml in the control group. Levels of 25-OH Vit D and other tested minerals were significantly lower while calcium:magnesium (Ca:Mg) ratio, and calcium:phosphorus (Ca:P) ratio were significantly higher in the breast cancer group. Significant negative correlation was detected between phosphorus and calcium, ionized calcium , calcium magnesium ratio, and calcium phosphorus ratio. Conclusion: It is not only the deficient levels of Vit D and other related minerals, but the combination of the abnormal levels of all the studied parameters that might contribute to the development of cancer. Further studies with larger number of patient are needed. 相似文献