全文获取类型
收费全文 | 24122篇 |
免费 | 1138篇 |
国内免费 | 203篇 |
学科分类
医药卫生 | 25463篇 |
出版年
2024年 | 14篇 |
2023年 | 180篇 |
2022年 | 349篇 |
2021年 | 621篇 |
2020年 | 309篇 |
2019年 | 481篇 |
2018年 | 598篇 |
2017年 | 462篇 |
2016年 | 611篇 |
2015年 | 634篇 |
2014年 | 871篇 |
2013年 | 980篇 |
2012年 | 1557篇 |
2011年 | 1746篇 |
2010年 | 977篇 |
2009年 | 827篇 |
2008年 | 1445篇 |
2007年 | 1631篇 |
2006年 | 1621篇 |
2005年 | 1623篇 |
2004年 | 1554篇 |
2003年 | 1490篇 |
2002年 | 1457篇 |
2001年 | 288篇 |
2000年 | 209篇 |
1999年 | 273篇 |
1998年 | 332篇 |
1997年 | 282篇 |
1996年 | 271篇 |
1995年 | 207篇 |
1994年 | 193篇 |
1993年 | 170篇 |
1992年 | 158篇 |
1991年 | 145篇 |
1990年 | 114篇 |
1989年 | 104篇 |
1988年 | 97篇 |
1987年 | 74篇 |
1986年 | 67篇 |
1985年 | 68篇 |
1984年 | 60篇 |
1983年 | 40篇 |
1982年 | 41篇 |
1981年 | 49篇 |
1980年 | 25篇 |
1979年 | 23篇 |
1978年 | 22篇 |
1977年 | 23篇 |
1976年 | 13篇 |
1975年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
71.
Tadateru Takayama Takafumi Hiro Masakazu Yamagishi Hiroyuki Daida Satoshi Saito Tetsu Yamaguchi Masunori Matsuzaki 《Circulation journal》2007,71(2):271-275
BACKGROUND: There have been few multicenter studies using intravascular ultrasound (IVUS) to assess the process of atherosclerosis in a Japanese population with hypercholesterolemia that is being treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for control of low-density lipoprotein-cholesterol. METHODS AND RESULTS: An open-label multicenter study is planned to evaluate with IVUS whether treatment with rosuvastatin for 76 weeks results in regression of coronary artery atheroma volume in patients who have coronary heart disease (CHD) and hypercholesterolemia. Sample size is 200 subjects with CHD who are to undergo percutaneous coronary intervention. The planned duration is between October 2005 and October 2008. CONCLUSIONS: The COSMOS study will be the first multicenter cardiovascular study in a Japanese population and may provide new evidence on the effects of rosuvastatin on the progression of coronary atherosclerotic lesions. 相似文献
72.
We report a rare case of neglected fracture dislocation of the second and third carpometacarpal joints, which was treated by arthrodesis of the involved joints. 相似文献
73.
74.
Shohachi Suzuki Satoshi Nakamura Hideki Ishida Takanori Sakaguchi Atsushi Serizawa Hiroyuki Konno Shozo Baba Hiroyuki Muro Isao Kosugi Eisaku Gu 《Surgery today》1996,26(8):635-639
Hepatic angiomyolipoma is a rare tumor composed of spindle-shaped and epithelioid smooth muscle cells, adipose tissue, and proliferating blood vessels. We report the first documented case of this tumor developing in a patient with ulcerative colitis. A solitary tumor (7.5×7.5×7cm) was detected in the left lateral segment of the liver and a left hepatic lobectomy was performed. The diagnosis of angiomyolipoma was confirmed by a pathological examination. We also review the literature on previously reported cases of hepatic angiomyolipoma. 相似文献
75.
Eimoto Hiroyuki; Tsutsumi Masahiro; Nakajima Akira; Yamamoto Kazuhiko; Takashima Yokashima; Maruyama Hiroshi; Konishi Yoichi 《Carcinogenesis》1988,9(12):2325-2327
Expression of glutathione S-transferase placental form (GST-)in human lung carcinoma tissue taken at autopsy or biopsy wasinvestigated immunohistochemically. All of 34 cases of squamouscell carcinomas, including poorly, moderatelyand well-differentiatedexamples were shown to stain positively for GST-. Poorly differentiatedadenocarcinomas were, however, negatively stained (0/5 cases),while moderately and well differentiated adenocarcinomas werefound tostain with GST- at rates of 69% (9/13 cases) and 71%(5/7 cases), respectively. Six cases of small cell carcinomasexamined were all negative. The results indicate that GST- maybe a useful marker fornon-small cell type lung cancer, especiallysquamous cell carcinoma which is in agreement with findingsfor rat lung neoplastic lesions reported previously. 相似文献
76.
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis 总被引:8,自引:4,他引:4
Denda Ayumi; Ura Hitoshi; Tsujiuchi Toshifumi; Masahiro Tsutsumi; Eimoto Hiroyuki; Takashima Yoshiharu; Kitazawa Shunji; Kinugasa Tetsuo; Konishi Yoich 《Carcinogenesis》1989,10(10):1929-1935
The effects of inhibitors of arachidonic acid metabolism andantioxidants on the rat liver tumor promotion activity of phenobarbital(PB) were assessed using the enzyme-altered focus as the end-pointlesion. Fischer 344 male rats were initiated with N-nitrosodiethylamine(200 mg/kg) and then divided into five groups placed on basaldiet, diet containing 0.05% PB, diet containing 0.05% PB plus0.75%, 1% or 1.5% levels of various inhibitors of arachidonicacid metabolism or antioxidants, or diet containing 1% or 1.5%inhibitors or antioxidants alone for 10 weeks, and then killed.-Bromo phenacyl bromide, an inhibitor of phospholipase A2 significantly inhibited the promotion activity of PB at dose levelsof 0.75% and 1.5%, reaching plateau at 0.75%. Both quercetin,an inhibitor of lipoxygenase, and morin, a dual inhibitor oflipoxygenase-cyclooxygenase, significantly reduced the promotionactivity of PB at the 1.5% but not 0.75% dose levels. Moreover,acetylsalicylic acid, an inhibitor of cyclooxygenase dose-dependentlyinhibited the promotion activity of PB. Among the antioxidantsinvestigated, vitamin E did not affect, but n-propyl gallateand ethoxyquin exerted a dose-dependent inhibition of PB promotion.These results are strongly suggestive of an involvement of phospholipaseA2 lipoxygenase and cyclooxygenase arachidonic acid metabolicpathways in the mechanisms underlying PB enhancement of hepatocarcinogenesis. 相似文献
77.
Hiroyuki Ito Reiko Takikawa Yoshihisa Kurachi Tsuneaki Sugimoto 《Naunyn-Schmiedeberg's archives of pharmacology》1989,339(1-2):244-246
Summary Effects of verapamil on the acetylcholine (ACh)-induced K+ current were examined in single atrial cells, using the tight-seal whole-cell clamp technique. The pipette solution contained guanosine-5-triphosphate (GTP) or guanosine-5-O-(3-thiotriphosphate) (GTP-S, a non-hydrolysable GTP analogue). In GTP-loaded cells, ACh induced a specific K+ current, which is known to be mediated by pertussis toxin-sensitive GTP-binding (G) proteins. Verapamil (0.1–100 M) depressed the ACh-induced K+ current in a concentration-dependent fashion. In GTP-S-loaded cells, the K+ current remained persistently after wash-out of ACh, probably due to irreversible activation of G proteins by GTP-S. Verapamil (0.1–100 M) also depressed the intracellular GTP-S-induced K+ current. However, the magnitude of verapamil-depression of the K+ current in GTP-S-loaded cells was significantly smaller than that in GTP-loaded cells at concentrations between 1 and 10 M of the drug. From these results, it is suggested that verapamil may block not only the function of muscarinic ACh receptors but also of G proteins and/or the K+ channel itself and thereby depress the ACh-induced K+ current in isolated atrial myocytes.Supported by grants from the Ministry of Education, Science and Culture of Japan and the Research Program on Ca Signal Control
Send offprint requests to Y. Kurachi at the above address 相似文献
78.
Transient receptor potential (TRP) channels provide an enormous variability of Ca(2+) influx mechanisms triggered by a wide range of stimuli. In this review, we discuss the activation properties of the Ca(2+)- and Mg(2+)-permeable TRP channel of the vanilloid subfamily TRPV4. This channel is activated by various physical and chemical stimuli, such as cell swelling, heat, phorbols and, probably, by endogenous ligands, which are able to induce Ca(2+) entry. Not much is known about the regulation of this channel. We will refer only to a mechanism of Ca(2+)-dependent inhibition of TRPV4. Possible functional roles of this channel will be correlated with its observed expression pattern. Finally, we discuss the structural determinants of TRPV4 channel function. 相似文献
79.
Epstein-Barr virus (EBV) is an important pathogen in human immunodeficiency virus (HIV)-infected individuals that causes lymphoma and other lymphoproliferative disorders upon disease progression; however, interaction between the two viruses during acute infection is not well known. Expression of CCR5, a major coreceptor for HIV, was enhanced on CD4+ T cells from patients with acute EBV infection. Furthermore, susceptibility of those cells to R5-HIV-1, but not X4-HIV-1, was increased. EBV effects on CCR5 expression on or susceptibility to R5-HIV-1 of CD4+ T cells did not require coinfection of the same cell with the two viruses, because CD4+ T cells from patients with acute EBV infection were not infected with EBV. Considering that both HIV and EBV are transmitted by intimate contact, such possible interaction between the two viruses may have implications for viral transmission and the pathogenesis of HIV disease. 相似文献
80.