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51.
Rihani R Barbar M Faqih N Halalsheh H Hussein AA Al-Zaben AH Rahman FA Sarhan M 《Pediatric transplantation》2012,16(4):E99-E105
CHS is a rare hereditary fatal disease, if not treated. APs occur in 85% of patients and are usually the main cause of mortality, and HSCT from HLA-matched related and unrelated donors is the only effective treatment for CHS and prevents recurrences of APs. We reviewed the records of three patients with CHS who underwent UCBT at KHCC. Records were examined for clinical features at the time of UCBT, conditioning regimens, morbidities, and outcomes. Conditioning comprised BU, cyclophosphamide, horse ATG, and etoposide. All patients tolerated the conditioning well. Two patients are alive, one with mixed and the other with full donor chimerism; hematologic and immunologic defects of CHS have been corrected in both patients. They show no evidence of recurrences of APs and have normal growth and development. In patients with CHS who lack HLA-matched related and unrelated donors, UCBT is a suitable alternative source of stem cells to restore immunologic and hematologic functions and prevent AP relapses, even in mixed chimeric states. Long follow-up and close monitoring are essential to evaluate the long-term benefits of using UCBT in patients with CHS. 相似文献
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Al Kadri HM Al-Moamary MS Elzubair M Magzoub ME AlMutairi A Roberts C van der Vleuten C 《Advances in health sciences education : theory and practice》2011,16(5):553-567
The aim of this study is to explore the effects of clinical supervision, and assessment characteristics on the study strategies
used by undergraduate medical students during their clinical rotations. We conducted a qualitative phenomenological study
at King Saud Bin Abdulaziz University for Health Sciences, College of Medicine, Riyadh, Saudi Arabia during the period from
November 2007 to December 2008. We conducted semi-structured focus groups interviews with students and conducted individual
interviews with teachers and students to explore students’ and clinical teachers’ perceptions and interpretations of factors
influencing students’ study strategies. Data collection was continued until saturation was reached. We used Atlas-ti Computer
Software (Version 5.2) to analyse the data, apply the obtained themes to the whole dataset and rearrange the data according
to the themes and sub-themes. Analysis of data from interviews with twenty-eight students and thirteen clinical supervisors
yielded three major themes relating to factors affecting students’ study strategies: “clinical supervisors and supervision”,
“stress and anxiety” and “assessment”. The three themes we identified played a role in students’ adoption of different study
strategies in the “community of clinical practice”. It appeared that teachers played a key role, particularly as assessors,
clinical supervisors and as a source of stress to students. 相似文献
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Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma 下载免费PDF全文
Hadeel Halalsheh Mary Beth McCarville Michael Neel Mark Reynolds Michael C. Cox Alberto S. Pappo 《Pediatric blood & cancer》2018,65(10)
Mesoblastic nephroma is the most frequent renal tumor in newborns and young infants, and the cellular type is characterized by an ETV6–NTRK fusion, which constitutively activates the tropomyosin‐related kinase (TRK) signaling pathway. Larotrectinib is a highly selective TRK inhibitor with activity in adult and pediatric patients who have TRK fusions. We present a rare case of a patient with mesoblastic nephroma metastatic to bone who had a dramatic response to larotrectinib. 相似文献
55.
Mona Y. Alsheikh Maram A. Alzahrani Norah A. Alsharif Hadeel M. Altowairqi Shahad A. Asiri Bushra M. Althubaiti Ali M. Alshahrani Ahmed I. Fathelrahman Moudi M. Alasmari Amal F. Alotaibi 《Saudi Pharmaceutical Journal》2021,29(12):1383-1391
Drug shortages continue to pose a significant threat to public health and safety. Drug shortages not only worsen patient outcomes, but also significantly burden healthcare systems with additional costs. This study aimed to assess community pharmacy staff knowledge, opinion, and practice toward drug shortages in Saudi Arabia from November 2019 to March 2020. This was a cross-sectional study carried out among 1,008 community pharmacists from Saudi Arabia using a validated, self-administered and Internet-based survey. Analysis was done using chi square and fisher exact tests. Most participants were males (97.2%), less than 30 years old (48.1%), and non-Saudi citizens (94.4%), and 72.0% had good knowledge of drug shortages (score = 4–5). Around 36.0% reported that it takes 1–3 days to receive a response to the shortage report. There was a statistically significant association between the professional level of the community pharmacists and their opinion about reporting drug shortages (P < .05). Most community pharmacies (56.2%) did not receive any notification about drug shortages. In conclusion, most community pharmacists are knowledgeable and have good practice regarding drug shortages, but their opinions about drug shortages differ according to each pharmacy reporting policy. 相似文献
56.
Hadeel Hassan Anne Pinches Susan V. Picton Robert S. Phillips 《Journal of neuro-oncology》2017,132(1):13-13
Diagnosis of a pediatric high grade brain stem glioma is devastating with dismal outcomes. This systematic review and meta-analysis was undertaken to determine the survival rates and assess potential prognostic factors including selected interventions. Studies included involved pediatric participants with high grade brain stem gliomas diagnosed by magnetic resonance imaging or biopsy reporting overall survival rates. Meta-analysis was undertaken using a binomial random effects model. Sixty-five studies (2336 participants) were included. Meta-analysis showed 1 year overall survival (OS) of 41% (95% confidence interval (CI) 38–44%, I-sq 52%, 2083 participants), 2 year OS of 15.3% (95% confidence interval 12–20%, I-sq 73.1%, 1329 participants) and 3 year OS of 7.3% (95% confidence interval 5.2–10%, I-sq 26%, 584 participants). Meta-analyses of median overall survival results was not possible due to the lack of reported measures of variance. Subgroup analysis comparing date of study, classification of tumor, use of temozolomide, non-standard interventions or phase 1/2 versus other studies demonstrated no difference in survival outcomes. There was insufficient data to undertake subgroup meta-analysis of patient age, duration of symptoms, K27M histone mutations and AVCR1 mutations. Survival outcomes of high grade brain stem gliomas have remained very poor, and do not clearly vary according to classification, phase of study or use of different therapeutic interventions. Future studies should harmonize outcome and prognostic variable reporting to enable accurate meta-analysis and better exploration of prognosis. 相似文献
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Marzouk Huda Farag Yomna El-Hanafi Hadeel M. Ibrahim Eman 《Clinical rheumatology》2018,37(12):3397-3403
Clinical Rheumatology - Familial Mediterranean fever (FMF) is an autoinflammatory disorder. It is caused by mutations in the MEFV gene encoding the pyrin protein, which regulates the innate... 相似文献
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HadeelA.A.Noormohammed 《广州医学院学报》2003,31(1):90-94
Lactase (β-D-galactosidase EC 3. 2. 1. 23 )generally exists in microorganism and many kinds of animals and plants like almond, apricot, peach, soybean,coffee bean and snail. In microorganism category,mold and yeast can produce this enzyme. Due to the fact that yeast is safe, unvirulent and easy to culture, using it as a source of enzyme seems relatively ideal.Thus, a lot of studies corresponding to this field hasbeen conducted 相似文献
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Nora Alkhudair Majed Alshamrani Hadeel Samarkandi Hajer Almodaheem Hana Alabdulkarim Mai Alsaqaaby Fouad Alnajjar Hashem Alhashem Mohammed Bakkar Shouki Bazarbashi Mohammed Alnahedh Feras Alfraih Mohammad Alawagi Ahmed Al-jedai 《Saudi Pharmaceutical Journal》2021,29(2):115-120
Cancer is widely recognized as a major global health problem and is estimated to rank as one of the leading causes of death worldwide. Saudi Arabia has undergone remarkable socioeconomic development in the past 40 years which has contributed to the increase in cancer incidence. The high costs of new oncology medications in combination with uncertainty of long-term effectiveness and safety outcomes highlight the importance of considering value, in terms of clinical outcomes, relative to cost. We convened a group of experts to discuss key factors impacting the current state of cancer management in Saudi Arabia and to agree on a list of recommendations, with a focus on value-based care, considering evidence, patients, and costs. 相似文献
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