Taurine effects on background impulse activity of the internal geniculate body neurons and mesencephalic inferior tubers of white rats

Microelectrophysiological and computer techniques were used in the study of background impulse activity (BIA) of the internal geniculate body (IGB) neurons and mesencephalic inferior tubers (MIT) of white rats. Definite differences were found in BIA by regularity, dynamic types and modality of interimpulse histograms. Mean frequency of MIT neuron discharges was 16-17 Hz and was about 3 times higher than in neurons of the IGB. Intraperitoneal injection of taurin noticeably suppressed neuronal activity in both nuclei. The drug reduced mean frequency of background impulse discharges both in MIT and IGB. Thus, taurin produces primarily suppressing modulating effect on neuronal activity of IGB and MIT.     

Effect of manual therapy on clinico-pathophysiological status and central hemodynamics in patients with ischemic heart disease

AIM: To elucidate effects of manual therapy on clinical status, central hemodynamics and parameters of Holter monitoring in ischemic heart disease (IHD) patients with angina of effort. MATERIAL AND METHODS: The examination of 70 IHD patients (functional class II-III) included Kubicek tetrapolar chest rheography in modification of Yu. G. Pushkar, bicycle exercise, 24-h Holter ECG monitoring. The condition of the vertebromotor segments was evaluated at manual tests. RESULTS: The addition of manual therapy to combined treatment of IHD patients improves sympathetic innervation in the cervicothoracic segments, depresses myofascial hypertonicity, diminishes sympathicotonic effects on the heart, enhances myocardial, coronary and aerobic reserves. CONCLUSION: The results of the study allow recommending adjuvant manual therapy in combined treatment of IHD.     

The effect of melatonin on the indices of biological age, on longevity and on the development of spontaneous tumors in mice

Fifty female CBA mice were given melatonin with drinking water (20 mg/l) for 5 consecutive days monthly, beginning from the age of 6 months, until natural death. Another 50 intact mice were used as controls. Melatonin failed to significantly influence body weight or food consumption. Age-related switching-off of estrus function was delayed, body temperature decreased. Somewhat decreased motor activity did not affect physical one or endurance. Increase in life span led to higher spontaneous tumor incidence. Another experiment using 20 animals of the same line showed melatonin to inhibit free-radical processes. A conclusion was drawn that caution should be exercised before melatonin is recommended for long-term administration as a geroprotector.     

Prognostic value of creatine kinase MB-fraction and TroponinT increase in patients after coronary bypass grafting (data of 3-year prospective observation)

The aim of this work was to investigate prognostic value of creatine kinase MB-fraction and troponin T increase in patients after coronary bypass grafting (during 3-year prospective observation). Parameters were studied in 6, 12, 48 and 72 hours after surgical myocardial revascularization. It was revealed that increase of myocardial necrosis markers is associated with significant more frequent development of cardiovascular complications during 3-year prospective observation.     

Cyclic nucleotides and serotonin in the blood of patients with functional and inflammatory diseases of the large intestine

The blood levels of cyclic nucleotides and serotonin were measured in 143 patients with functional and inflammatory diseases of the large intestine. The patients were divided into 3 groups administered various treatment: drug (basic) therapy in Group 1, basic therapy + alternating magnetic field in Group 2, and basic therapy + sinusoidal modulated currents in Group 3. Follow-up of the examined parameters over the course of treatment has shown that by day 16 of inpatient treatment they normalize, this demonstrating the treatment efficacy.     

The dependence of estradiol and progesterone reception in the endometrium on its histological structure in women with the syndrome of luteal phase failure

A study of the level of the sex steroid receptors in the endometrium of women with the syndrome of insufficiency of the luteal phase of the cycle (ILP-syndrome) has shown that disorders of receptor processes affect, first of all, progesterone receptors. An increase in a degree of a delay of endometrial development was accompanied by a rise of the level of progesterone in the endometrium which depended on the estradiol-progesterone ratio in the circulation, detectable on the 20th day of the menstrual cycle. The ILP-syndrome is characterized by the sufficient induction of progesterone receptors at the end of the proliferative--the beginning of the luteal phase of the cycle and by their insufficient inhibition with a low level of progesterone in the middle of the luteal phase. Insufficient synthesis of receptors as a result of sharp hypoestrogenemia is less frequent. The primary affection of the receptor apparatus as a cause of the ILP-syndrome against a normal hormonal background in the examinees was undetectable.     

Selective involvement of the gastrointestinal tract in amyloidosis in a female patient with periodic disease and intact kidneys]

The authors describe a rare case of amyloidosis in a female patient suffering from periodic disease (PD) for 18 years without any clinico-laboratory signs of renal impairment but with marked clinical, (malabsorption, cachexia), endoscopic, x-ray and other manifestations of gastrointestinal amyloidosis. This case is of interest since patients suffering from amyloidosis due to PB develop malabsorption very rarely, namely in 2-3% of cases. As a rule, it develops in patients with pronounced chronic renal failure on hemodialysis or with a history of kidney transplantation. In this particular case, the patient demonstrated selective marked damage to the gastrointestinal tract, with the kidneys remaining practically intact. A possibility of the indicated variety of amyloidosis should be considered in specification of the genesis of persistent diarrhea in PB patients.