Immediate results of surgical treatment of stomach cancer

Results of surgical treatment of 346 patients with cancer of the stomach are presented. All the patients underwent extended D2 and D3 lymphadenectomy. Up-to-date aspects of surgical treatment of stomach cancer, including intraoperative staging of cancer, spectrum of surgeries, their technical features, postoperative complications, lethality are outlined. Extended lymphadenectomy increases insignificantly time of surgery, rate of postoperative complications, postoperative lethality compared with standard surgeries in cancer of the stomach.     

DNA comet assay for evaluation of genotoxic effects in risk groups

DNA comet assay (CA), gel electrophoresis of single cells, is effective in evaluating the genetic (genotoxic) effects of endogenous and exogenous agents. CA was used to study the extent of spontaneous or UV-induced DNA damages in the leukocytes in two groups at genetic risk: in Chernobyl accident liquidators and patients with familial Mediterranean fever (FMF). There was a significant increase in the number of UV-induced and excision repair-mediated DNA breaks in both risk groups as compared to control samples. The spontaneous extent of DNA breaks in the cells of the liquidators and FMF patients were similar to those in the controls. The extent of oxidative DNA damages detected during incubation with the endonuclease enzymes formamidopyrimidine glycosylase and endonuclease III were also determined in FMF patients. There were no statistically significant differences in the extent of oxidative DNA damage in the cells of FMF patients as compared to the controls. The findings give grounds to recommend CA for biomonitoring of genotoxic effects.     

The clinical and prognostic information value of painless myocardial ischemia in the early postinfarct period]

A study was made of painless myocardial ischemia in the early postinfarction period (day 14) in order to define its influence on the clinical course and immediate prognosis. 25 patients aged 32 to 60 years with acute primary myocardial infarction were examined. 17 patients had large-focal and 8 small-focal infarction. The patients received diurnal ECG monitoring and physical exercise test on a treadmill. An overwhelming majority of the patients manifested myocardial ischemia not correlating with the rate of angina pectoris attacks. In the patients with small-focal infarction, angina pectoris occurred more frequently and was longer. It has been discovered that the total diurnal duration of transitory myocardial ischemia in the early postinfarction period is a more informative indicator of the immediate prognosis as compared to physical exercise tolerance.     

Structural and functional changes in the parathyroid glands in patients with periodic disease

The results obtained during radioimmunoassay, biochemistry and morphological studies in patients with periodic disease point to the development of hypoparathyroid hormonemia, reduction of the substrate of the parathyroid parenchyma, responsible for the synthesis of parathyroid hormone. These alterations became aggravated in the course of the development of amyloidosis. The latter is not always related to amyloidosis of the parathyroid glands themselves.