Implicit memory for pictures in amnesia: Role of etiology and priming task.

This study examined the performance of patients with Korsakoff and non-Korsakoff amnesia on tests of picture priming. Both groups showed intact priming on a picture-naming task but impaired priming on a fragment-completion task when fragmented pictures were presented at study. When whole pictures were presented at study, patients with non-Korsakoff amnesia showed intact priming, but Korsakoff patients' priming remained impaired. Both groups performed equally poorly on a picture-recognition task. It is concluded that non-Korsakoff patients show intact picture priming when explicit memory does not contaminate fragment-completion performance. Korsakoff patients, in contrast, show a selective impairment in the perceptual processes that mediate picture-fragment completion priming. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Towards a Logic for Performance and Mobility

Klaim is an experimental language designed for modeling and programming distributed systems composed of mobile components where distribution awareness and dynamic system architecture configuration are key issues. StocKlaim [R. De Nicola, D. Latella, and M. Massink. Formal modeling and quantitative analysis of KLAIM-based mobile systems. In ACM Symposium on Applied Computing (SAC). ACM Press, 2005. Also available as Technical Report 2004-TR-25; CNR/ISTI, 2004] is a Markovian extension of the core subset of Klaim which includes process distribution, process mobility, asynchronous communication, and site creation. In this paper, MoSL, a temporal logic for StocKlaim is proposed which addresses and integrates the issues of distribution awareness and mobility and those concerning stochastic behaviour of systems. The satisfiability relation is formally defined over labelled Markov chains. A large fragment of the proposed logic can be translated to action-based CSL for which efficient model-checkers exist. This way, such model-checkers can be used for the verification of StocKlaim models against MoSL properties. An example application is provided in the present paper.     

A simulator for oscillometric blood-pressure signals to test automated noninvasive sphygmomanometers

A device was developed allowing to generate simulated human blood pressure signals for the purpose of testing the performance of automated noninvasive sphygmomanometers. The apparatus reproducibly generates blood-pressure oscillations synthesized from prerecorded measurements on human subjects. These real-life data allow for a much better evaluation of the accuracy of blood-pressure measurements than the existing simulators using artificial and thus less realistic waveforms. To assess the performance of a given sphygmomanometer under both stable and varying conditions, generated signals can be repeated in their original shape or distorted by well-defined artifacts. In comparison to clinical tests, the procedural influences on the performance testing of sphygmomanometers are largely reduced when the simulator is used.     

Discovery of potent, orally bioavailable small-molecule inhibitors of the human CCR2 receptor

We recently reported the discovery of a series of 2-thioimidazoles as CCR2 antagonists. The most potent molecules of this series, the 4,5-diesters, were rapidly hydrolyzed to the inactive acids and were found to be metabolically unstable. Herein we describe the synthesis of a number of analogues with heterocyclic bioisosteric replacements of the ester group(s). Small 5-membered heterocyclic substituents at the 4-position gave highly potent CCR2 antagonists. Hydrolysis of the 5-ester is diminished, thus imparting these compounds with sufficient stability and systemic exposure after oral administration to warrant further study of the in vivo pharmacology of these functional CCR2 inhibitors.     

The Antimicrobial Activity of Peripheral Blood Neutrophils Is Altered in Patients with Primary Ciliary Dyskinesia

The airways of patients with primary ciliary dyskinesia (PCD) contain persistently elevated neutrophil numbers and CXCL8 levels. Despite their abundance, neutrophils fail to clear the airways from bacterial infections. We investigated whether neutrophil functions are altered in patients with PCD. Neutrophils from patients and healthy controls (HC) were isolated from peripheral blood and exposed to various bacterial stimuli or cytokines. Neutrophils from patients with PCD were less responsive to low levels of fMLF in three different chemotaxis assays (p < 0.05), but expression of the fMLF receptors was unaltered. PCD neutrophils showed normal phagocytic function and expression of adhesion molecules. However, PCD neutrophils produced less reactive oxygen species upon stimulation with bacterial products or cytokines compared to HC neutrophils (p < 0.05). Finally, the capacity to release DNA, as observed during neutrophil extracellular trap formation, seemed to be reduced in patients with PCD compared to HC (p = 0.066). These results suggest that peripheral blood neutrophils from patients with PCD, in contrast to those of patients with cystic fibrosis or COPD, do not show features of over-activation, neither on baseline nor after stimulation. If these findings extend to lung-resident neutrophils, the reduced neutrophil activity could possibly contribute to the recurrent respiratory infections in patients with PCD.     

A survey on hygienic practices and their impact on the microbiological quality and safety in the Rwandan milk and dairy chain

This study assessed the status of hygienic practices in the Rwandan milk and dairy chain. Data collection was based on interviews with the help of a survey and site visits to farms, collection centres, milk processing companies, small‐scale cheese plants, wholesale points, supermarkets and milk shops. The observed status of good practices was further linked to actual microbiological data. It was concluded that there is a major gap in compliance with hygienic practices leading to higher levels of contaminated dairy products.     

The structure-function relationship of the lipases from Pseudomonas aeruginosa and Bacillus subtilis

Within the BRIDGE T-project on lipases we investigate the structure-functionrelationships of the lipases from Bacillus subtilis and Pseudomonasaeruginosa. Construction of an overproducing Bacillus. strainallowed the purification of > 100 mg lipase from 30 l culturesupernatant. After testing a large variety of crystallizationconditions, the Bacillus lipase gave crystals of reasonablequality in PEG-4000 (38-45%), Na₂SO₄ and octyl-ß-glucosideat 22°C, pH 9.0. A 2.5 Å; dataset has been obtainedwhich is complete from 15 to 2.5 A resolution. P.aeruginosawild-type strain PAC1R was fermented using conditions of maximumlipase production. More than 90% of the lipase was cell boundand could be solubilized by treatment of the cells with TritonX-100. This permitted the purification of 50 mg lipase. So far,no crystals of sufficient quality were obtained. Comparisonof the model we built for the Pseudomonas lipase, on the basisof sequences and structures of various hydrolases which werefound to possess a common folding pattern (/ß hydrolasefold), with the X-ray structure of the P.glumae lipase revealedthat it is possible to correctly build the structure of thecore of a protein even in the absence of obvious sequence homologywith a protein of known 3-D structure.     

Finding a needle in a haystack: an interactive video archive explorer for professional video searchers

Professional video searchers typically have to search for particular video fragments in a vast video archive that contains many hours of video data. Without having the right video archive exploration tools, this is a difficult and time consuming task that induces hours of video skimming. We propose the video archive explorer, a video exploration tool that provides visual representations of automatically detected concepts to facilitate individual and collaborative video search tasks. This video archive explorer is developed by employing a user-centred methodology, which ensures that the tool is more likely to fit to the end user needs. A qualitative evaluation with professional video searchers shows that the combination of automatic video indexing, interactive visualisations and user-centred design can result in an increased usability, user satisfaction and productivity.     

Model checking mobile stochastic logic

The Temporal Mobile Stochastic Logic (MoSL) has been introduced in previous work by the authors for formulating properties of systems specified in StoKlaim, a Markovian extension of Klaim. The main purpose of MoSL is to address key functional aspects of global computing such as distribution awareness, mobility, and security and their integration with performance and dependability guarantees. In this paper, we present MoSL⁺${\text{<small-caps>MoSL</small-caps>}}^{+}$, an extension of MoSL, which incorporates some basic features of the Modal Logic for MObility (MoMo), a logic specifically designed for dealing with resource management and mobility aspects of concurrent behaviours. We also show how MoSL⁺${\text{<small-caps>MoSL</small-caps>}}^{+}$ formulae can be model-checked against StoKlaim specifications. For this purpose, we show how existing state-based stochastic model-checkers, like e.g. the Markov Reward Model Checker (MRMC), can be exploited by using a front-end for StoKlaim that performs appropriate pre-processing of MoSL⁺${\text{<small-caps>MoSL</small-caps>}}^{+}$ formulae. The proposed approach is illustrated by modelling and verifying a sample system.     

Designing for collaboration: a study in intergenerational social game design

This paper presents a study of a computer game designed for the elderly, allowing them to train their memory while playing the game. The game supports both a single-player and a multiplayer mode, in which the elderly can play with their friends or family using an embedded video chat application. The main question that is addressed in this paper is how the elderly gamers’ experience is influenced by the possibility to communicate directly with the other players. The study presents a comparison of the game experience and appreciation of older users and their (grand)children playing the game together, with or without the video chat application. Most importantly, the study shows that the added value of video chat is not limited to social contact, but that it also provides opportunities for the younger generation to assist the elderly during the game. In conclusion, the paper points out some intergenerational game design implications, and some future research suggestions.