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91.
ABSTRACTSuperheaters are high-temperature cross-flow heat exchangers. Steam flows inside the tubes, and the flue gas outside in a direction perpendicular to the axes of the tubes. However, they differ very substantially from the other heat exchangers operating at low temperatures. Superheaters are characterized by complex flow system and high tube walls temperature. Superheaters are among the most exposed to damaging pressure elements of steam boilers. Damage to the superheater causes about 40% of emergency shutdowns of boilers. The paper presents the boiler superheater model with distributed parameters, which is used to determine on-line the degree of superheater fouling by ash. 相似文献
92.
Marcin ?roda Katarzyna Cholewa-KowalskaMarek Ró?ański Marek Nocuń 《Optical Materials》2011,33(3):397-401
Glasses of different matrix (phosphate, borate, silicate and lead-silicate) were studied for their optical properties. The effect of Er dopant on transmittance and luminescence properties was presented. The significant “red shift” and “blue shift” of UV edge absorption were discussed based on the changes in the framework of the borate and phosphate glasses, respectively. It was showed that the integral intensity of the two main optical absorption transitions monotonically increases with the order: phosphate < borate < silicate < lead-silicate. Ellipsometric measurement was applied to obtain the refractive index of the glasses. The correlation between the shift of edge absorption and the change of refractive index was presented. Effect of glassy matrix on luminescence of Er3+ was discussed. 相似文献
93.
94.
In this paper we present results of detailed spectroscopic studies of Tb3+ luminescence from BaF2:0.075 mol% Tb performed at Superlumi station of Hasylab, DESY, Hamburg and at Institute of Physics, N. Copernicus University, Torun, Poland (IF UMK Torun).We have measured UV/VUV excitation spectra of the dominant blue Tb3+ luminescence and emission spectra under excitation into various bands found from the excitation spectra. The excitation spectra are dominated by the two well known broad bands due to the parity and spin-allowed (SA) 4f8 → 4f75d transitions. The higher energy triple t-band and unresolved single e-band at lower energies are widely separated (10 Dq about 16,500 cm−1) reflecting the single d-electron energy in the high symmetry cubic crystal field with a relatively low contribution from the low symmetry component.In addition to these bands we have also detected a number of weaker bands at lower energy sides of both dominant SA bands. While the structured band with components at 252.8, 252.3, 250.4 and 248.4 nm clearly corresponds to the SF (spin-forbidden) band found earlier in LiYF4:Tb, the bands at 183, 178 and 172 nm have been never, to the best of our knowledge, reported before. We present arguments that these new bands are the SF counterparts of the triple SA t-band at about 158 nm. The d-f exchange energies for d(e) and d(t) electrons are different at 7779 and 8245 cm−1, respectively.Although the energy levels corresponding to the identified high and low spin (HS and LS) states of the 4f75d configuration are, in BaF2, well separated, there are no SA nor SF transitions generating d-f emission in BaF2:Tb. This is because the numerous 4f8 energy levels intercept the excitation energy from 4f75d levels leading to the well known blue and green Tb3+ 4f8 emissions. 相似文献
95.
Elbieta mudzka Klaudia Lustyk Monika Guch-Lutwin Barbara Mordyl Alicja Zakrzewska-Sito Pawe Mierzejewski Jolanta Jakowska Marcin Koaczkowski Jacek Sapa Karolina Pytka 《International journal of molecular sciences》2022,23(24)
Schizophrenia is a chronic mental illness, which remains difficult to treat. A high resistance to the available therapies, their insufficient efficacy, and numerous side effects are the reasons why there is an urgent need to develop new antipsychotics. This study aimed to assess the antipsychotic-like effects of JJGW08, a novel arylpiperazine alkyl derivative of salicylamide, in rodents. First, considering the JJGW08 receptor profile, we investigated the compound’s intrinsic activity towards dopamine D2 and serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors using functional assays. Next, we assessed the effect of JJGW08 on MK-801- and amphetamine-induced hyperlocomotion, its risk of inducing catalepsy and impairing motor coordination, as well as the anxiolytic-like effects in the four-plate and marble burying tests in mice. Finally, we investigated the antipsychotic-like properties of JJGW08 in rats using MK-801-induced hyperlocomotion and prepulse inhibition tests. We found that JJGW08 showed antagonistic properties at dopamine D2 and serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors. However, the effect on the 5-HT2A and 5-HT7 receptors was very weak. Moreover, the tested compound showed an antipsychotic-like effect in MK-801- and amphetamine-induced hyperlocomotion but not in a prepulse inhibition test in rats. Notably, JJGW08 demonstrated anxiolytic-like properties in both behavioral tests. Importantly, the compound did not induce catalepsy or motor coordination impairment in mice at antipsychotic-like doses. Our study suggests it is worth searching for new potential antipsychotics among arylpiperazine alkyl derivatives of salicylamide. 相似文献
96.
Micha Bulc Katarzyna Palus Jarosaw Caka Joanna Kosacka Marcin Nowicki 《International journal of molecular sciences》2022,23(9)
Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter of the central and peripheral nervous systems, predominantly secreted in the gastrointestinal tract, especially in the gut. 5-HT is a crucial enteric signaling molecule and is well known for playing a key role in sensory-motor and secretory functions in the gut. Gastroenteropathy is one of the most clinical problems in diabetic patients with frequent episodes of hyperglycemia. Changes in 5-HT expression may mediate gastrointestinal tract disturbances seen in diabetes, such as nausea and diarrhea. Based on the double immunohistochemical staining, this study determined the variability in the population of 5-HT-positive neurons in the porcine small intestinal enteric neurons in the course of streptozotocin-induced diabetes. The results show changes in the number of 5-HT-positive neurons in the examined intestinal sections. The greatest changes were observed in the jejunum, particularly within the myenteric plexus. In the ileum, both de novo 5-HT synthesis in the inner submucosal plexus neurons and an increase in the number of neurons in the outer submucosal plexus were noted. The changes observed in the duodenum were also increasing in nature. The results of the current study confirm the previous observations concerning the involvement of 5-HT in inflammatory processes, and an increase in the number of 5-HT -positive neurons may also be a result of increased concentration of the 5-HT in the gastrointestinal tract wall and affects the motor and secretory processes, which are particularly intense in the small intestines. 相似文献
97.
Fast advances in polymer science have provided new hydrogels for applications in drug delivery. Among modern drug formulations, polymeric type stimuli-responsive hydrogels (SRHs), also called smart hydrogels, deserve special attention as they revealed to be a promising tool useful for a variety of pharmaceutical and biomedical applications. In fact, the basic feature of these systems is the ability to change their mechanical properties, swelling ability, hydrophilicity, or bioactive molecules permeability, which are influenced by various stimuli, particularly enzymes. Indeed, among a great number of SHRs, enzyme-responsive hydrogels (ERHs) gain much interest as they possess several potential biomedical applications (e.g., in controlled release, drug delivery, etc.). Such a new type of SHRs directly respond to many different enzymes even under mild conditions. Therefore, they show either reversible or irreversible enzyme-induced changes both in chemical and physical properties. This article reviews the state-of-the art in ERHs designed for controlled drug delivery systems (DDSs). Principal enzymes used for biomedical hydrogel preparation were presented and different ERHs were further characterized focusing mainly on glucose oxidase-, β-galactosidase- and metalloproteinases-based catalyzed reactions. Additionally, strategies employed to produce ERHs were described. The current state of knowledge and the discussion were made on successful applications and prospects for further development of effective methods used to obtain ERH as DDSs. 相似文献
98.
Mischa Schmidt Jan Seedorf Stefano Napolitano Rosario G. Garroppo Andrea Cavaliere Thilo Ewald Armin Jahanpanah Zbigniew Kopertowski Marcin Pilarski Pawel Grochocki 《Peer-to-Peer Networking and Applications》2013,6(2):134-154
Application Layer Traffic Optimization (ALTO) has recently gained attention in the research and standardisation community as a way for a network operator to guide the peer selection process of distributed applications by providing network layer topology information. In particular P2P applications are expected to gain from ALTO, due to the many connections peers form among each other, often without taking network layer topology information into account. In this paper, we present results of an extensive intra-ISP trial with an ALTO-enhanced P2P filesharing software. In summary, our results show that—depending on the concrete setting and on the distribution of upload capacity in the network—ALTO enables an ISP to save operational costs significantly while not degrading application layer performance noticeably. In addition, based on our experience we are able to give advice to operators on how to save costs with ALTO while not sacrificing application layer performance at all. 相似文献
99.
Kocan Marcin Wagner Lothar Rack H. J. 《Journal of Materials Engineering and Performance》2005,14(6):765-772
This investigation examined the role of microstructure and surface finish on the high cycle fatigue (HCF) performance of TIMETAL
LCB (Ti-6.8Mo-4.5Fe-1.5Al). The as-received microstructure of LCB consisted of elongated β grains with a semicontinuous grain
boundary α layer. In contrast, a fine equiaxed β + spheroidized α LCB microstructure was achieved by hot swaging and solution
(recrystallization) anneal. The latter modification of the prior β grain structure, together with the size, morphology, and
distribution of the primary α phase, resulted in a significant enhancement in the tensile and HCF properties. Furthermore,
prestraining (PS), as would be expected during the fabrication of an automotive coil spring, and prior to aging for 30 min
at temperatures between 500 and 550 °C, led to additional increases in tensile strength. In contrast, the HCF performance
was always reduced when PS prior to aging was included in the overall processing procedure. Finally, shot-peening and roller-burnishing
both resulted in an increased fatigue life in the finite life regimen; however, significant reductions in the 107 cycle fatigue strengths were observed when these procedures were used. These observations have been explained by including
the effect of process-induced residual tensile stresses in the fatigue analysis, resulting in subsurface fatigue crack nucleation.
This paper was presented at the Beta Titanium Alloys of the 00’s Symposium sponsored by the Titanium Committee of TMS, held
during the 2005 TMS Annual Meeting & Exhibition, February 13–16, 2005 in San Francisco, CA. 相似文献
100.
Wochna A Niemczyk E Kurono C Masaoka M Majczak A Kedzior J Slominska E Lipinski M Wakabayashi T 《Journal of electron microscopy》2005,54(2):127-138
Detailed mechanisms of the switch of the cell death mode from apoptosis to necrosis remain to be solved, although the intracellular level of ATP and that of free radicals have been postulated to be the major factors involved in the mechanisms. In the present study menadione (MEN)-induced cell injury processes were studied using rho0 cells derived from human osteosarcoma 143B cells and parental rho+ cells co-treated with inhibitors of electron transfer chain of mitochondria or oligomycin, an inhibitor of ATP synthesis. Treatment of rho+ cells with 100 microM MEN induced apoptosis, which reached the maximum at 6 h, and was followed by an abrupt decrease thereafter, while necrotic cells (NC) increased continuously when they were judged by Annexin V and PI double staining. On the other hand, MEN induced apoptotic and necrotic changes much faster in rho0 cells compared to rho+ cells. The frequency to find apoptotic cells (AP) in the former cells was distinctly smaller than that to find NC judged by Annexin V and PI double staining. Electron microscopically, a major population of rho0 cells treated with MEN for 6 h consisted of intermediate cells, and a small number of AP co-existed. At 9 h of the treatment intermediate cells were exclusively seen, and AP were hardly detected. When parental rho+ cells were treated with MEN in the presence of oligomycin or oligomycin plus antimycin A both apoptotic and necrotic changes of the cells were distinctly accelerated. The intracellular level of superoxide in rho0 cells continuously increased after the MEN treatment, whereas that of ATP remained distinctly low before and after the MEN treatment compared to that in rho+ cells. These data suggest that the intracellular level of superoxide may be a key factor controlling the switch from apoptosis to necrosis. 相似文献