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61.
Graziela Brusch BrinquesMarco Antônio Záchia Ayub 《Journal of food engineering》2011,103(2):123-128
In the present research the survival of free and microencapsulated cells of a new strain of Lactobacillus plantarum BL011 under stress conditions was tested in sodium alginate or pectin, coated with sodium alginate or chitosan. Results for the simulated gastrointestinal medium (SGT) showed no change in viability of cells in relation to the control. However, the simulated gastric medium (GM) drastically reduced the viability under the tested conditions, with no significant differences between free and immobilized cells. Under refrigerated storage viability of immobilized cells were greatly enhanced compared to the free microorganisms, and the treatments showing the lowest loss of viability were those of 4% (w/v) pectin, 3% (w/v) sodium alginate coated with chitosan and a mixture of 2% (w/v) sodium alginate and 2% (w/v) pectin, respectively. Loss of viability of immobilized L. plantarum in 3% alginate coated with chitosan in yogurt was of 0.55 log cycles during 38 days of storage. The results of this study suggest the efficiency of immobilization techniques to increase the survival of lactobacilli in yogurt under refrigerated storage. 相似文献
62.
R Escher D Müller M Vogel S Miescher BM Stadler P Berchtold 《Canadian Metallurgical Quarterly》1998,102(3):820-828
Autoimmune thrombocytopenic purpura (AITP) is caused by autoantibodies predominantly against platelet membrane glycoproteins (GP) IIb/IIIa and GPIb/IX. Naturally occurring autoantibodies have been described against a variety of autoantigens; it has been suggested that perturbation of their regulation may be associated with autoimmune diseases. Using a combinatorial Fab phagemid library from an individual immunized with human RhD+ red blood cells, we evaluated the presence of natural anti-GPIIb/IIIa autoantibodies as well as their relation to AITP-associated anti-GPIIb/IIIa autoantibodies. Selection on native GPIIb/IIIa and characterization of positive clones by inhibition studies against murine monoclonal anti-GPIIb/IIIa antibodies and by DNA analysis revealed the presence of two distinct recombinant anti-GPIIb/IIIa autoantibodies, which partially inhibited binding of affinity-purified platelet-associated autoantibodies from 8/12 AITP patients. Our results demonstrated that GPIIb/IIIa-specific Fab directed against conformational epitopes within the GPIIb/IIIa complex may be cloned from the genome of an individual immunized with RhD+ red blood cells, who was not affected by AITP. The partial inhibition of binding of platelet-associated autoantibodies from AITP patients to GPIIb/IIIa by the recombinant anti-GPIIb/IIIa phage clones suggests recognition of closely related antigenic epitopes. These phage clones may represent down-regulated, potentially pathological autoantibodies and could be used as new tools for investigation of AITP. 相似文献
63.
Escher J 《Philosophical transactions. Series A, Mathematical, physical, and engineering sciences》2012,370(1964):1602-1615
Several recent results on the regularity of streamlines beneath a rotational travelling wave, along with the wave profile itself, will be discussed. The survey includes the classical water wave problem in both finite and infinite depth, capillary waves and solitary waves as well. A common assumption in all models to be discussed is the absence of stagnation points. 相似文献
64.
Dr. Bianca Schulte Maria König Prof. Dr. Beate I. Escher Sophie Wittenburg Matic Proj Valentina Wolf Carina Lemke Dr. Gregor Schnakenburg Prof. Dr. Izidor Sosič Prof. Dr. Hendrik Streeck Prof. Dr. Christa E. Müller Prof. Dr. Michael Gütschow Dr. Christian Steinebach 《ChemMedChem》2022,17(5):e202100732
Naturally occurring compounds represent a vast pool of pharmacologically active entities. One of such compounds is andrographolide, which is endowed with many beneficial properties, including the activity against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). To initiate a drug repurposing or hit optimization campaign, it is imperative to unravel the primary mechanism(s) of the antiviral action of andrographolide. Here, we showed by means of a reporter gene assay that andrographolide exerts its anti-SARS-CoV-2 effects by inhibiting the interaction between Kelch-like ECH-associated protein 1 (KEAP1) and nuclear factor erythroid 2-related factor 2 (NRF2) causing NRF2 upregulation. Moreover, we demonstrated that subtle structural modifications of andrographolide could lead to derivatives with stronger on-target activities and improved physicochemical properties. Our results indicate that further optimization of this structural class is warranted to develop novel COVID-19 therapies. 相似文献
65.
Electronic Markets - The IoT can help firms to innovate and to address new business opportunities. However, many companies face difficulties in developing products and services based on the IoT... 相似文献
66.
S. Pauly ;K. Kosiba ;P. Gargarella ;B. Escher ;K.K. Song ;G. Wang ;U. Kiihn ;J. Eckert 《材料科学技术学报》2014,30(6):584-589
Three different Cu-Zr-Co alloys, namely Cu40Zr37.5Co22.5, Cu42.5Zr45Co12.5 and Cu49Zr49Co2, were obtained by rapid cooling. The microstructure and phase formation of as-cast rods with diameters of 2 mm are compared with those of the respective ingots. An increasing Co content stabilises the B2 CuZr phase and leads to the precipitation of a ternary Cu-Zr-Co phase. The variation of the cooling rate affects the size of the B2 dendrites as well as the volume fraction and the morphology of the interdendritic phases. The mechanical properties were determined in compression and all alloys show a certain plastic deformability despite the presence of several binary and ternary intermetallic phases. The deformation mechanisms are discussed on the basis of the microstructures and the constituent phases. 相似文献
67.
W.J.D. Escher 《International Journal of Hydrogen Energy》1983,8(7):479-498
Since sustainable, technologically-converted solar energy is the likely basis for our post-fossil-energy future, there is a basic need for solar-produced fuels. It is noteworthy that heat and electricity, solely, are being developed as solar-energy delivery means, while historically civilizations depend on fuels. Hydrogen, a clean, efficiently-used fuel, can be readily derived from water using any of a number of both proved and prospective solar-energy conversion technologies—both direct and indirect (hydropower, wind, etc.). Solar/hydrogen (and oxygen) can also extend depleting fossil-energy resources while ameliorating environmental degradation. The Hydrogen Energy System concept is overviewed as background.A recent ‘Solar/Hydrogen Systems Assessment’ delineated early-availability systems based on photovoltaic, thermal/heat-engine, wind and hydropower solar conversion, and associated water electrolysis to yield product hydrogen and oxygen as ‘hydrogen energy’. Involved technologies being highly modular, good economics of equipment manufacture and deployment are inherent, as is early availability and as-needed rates of construction (in contrast, e.g., with nuclear-plant experience). Proved technological means exist for transporting, storing and distributing hydrogen energy to end-users.Most significant, both small-scale (local, dispersed) and large-scale (central, remote) solar/hydrogen generation facilities can be established in balance with prevailing societal-selection dictates. Involving a readily storable, transportable ‘energy currency’, then-existing hydrogen-energy systems can be inter-tied as desired, providing load-management-related economic advantages to both the energy-user and the ‘energy utility’ of that era. Future solar/hydrogen-electric residences might, as is illustrated, buy and sell hydrogen and electricity in a ‘grid-cooperative’ arrangement.The salient operative question concerns the efficacy of ‘conventional wisdom’ in the energy free-market decision-making process. Will early-enough, adequate level-of-effort programmes be implemented to ensure non-disruptive meeting of tomorrow's demand worldwide? In an aura of business-as-usual, solar/hydrogen's timely contribution to ‘picking up the load’ from exhaustible fossil fuels in the face of still-escalating world energy demand is judged most problematic. Consequently, an unprecedented cooperative world effort for the research, development, demonstration and deployment of solar hydrogen energy delivery capabilities is suggested. 相似文献
68.
Thomas M. Amrein Luca Andres Barbara Schönbächler Béatrice Conde-Petit Felix Escher Renato Amadò 《European Food Research and Technology》2005,221(1-2):14-18
Acrylamide was determined in 86 different almond products, such as roasted almonds, almond-containing bakery products, raw almonds, and marzipan. The highest acrylamide concentrations were found in dark roasted almonds, while only moderate acrylamide contents were determined in bakery products. Roasting experiments under different process conditions showed that acrylamide increases with time and that temperature has a much stronger effect on acrylamide formation than time. During roasting reducing sugars are consumed faster and to a larger extent than free asparagine, suggesting that the content of reducing sugars may be a critical factor for acrylamide formation in roasted almonds. Acrylamide was found to decrease in roasted almonds during storage at room temperature. 相似文献
69.
Electrochemical oxidation has been proposed for the elimination of pesticides, pharmaceuticals and other organic micropollutants from complex waste streams. However, the detrimental effect of halide ion mediators and the generation of halogenated by-products in this process have largely been neglected thus far. In this study, we investigated the electrochemical oxidation pathways of the β-blocker metoprolol in reverse osmosis concentrate (ROC) from a water reclamation plant using titanium anodes coated with Ru0.7Ir0.3O2 or SnO2-Sb metal oxide layers. The results of liquid chromatography-mass spectrometry analysis indicated that irrespective of the electrode coating the same oxidant species participated in electrochemical transformation of metoprolol in ROC. Although Ti/SnO2-Sb exhibited higher oxidizing power for the same applied specific electrical charge, the generation of large fractions of chloro-, chloro-bromo- and bromo derivatives was observed for both electrode coatings. However, degradation rates of metoprolol and its degradation products were generally higher for the Ti/SnO2-Sb anode. Chemical analyses of metoprolol and its by-products were complemented with bioanalytical tools in order to investigate their toxicity relative to the parent compound. Results of the bioluminescence inhibition test with Vibrio fischeri and the combined algae test with Pseudokirchneriella subcapitata indicated a substantial increase in non-specific toxicity of the reaction mixture due to the formed halogenated by-products, while the specific toxicity (inhibition of photosynthesis) remained unchanged. 相似文献
70.
The effect of fatty acid composition on the properties of patties standardised to contain 15% fat was studied. Patties were made of beef from 36 Brown Swiss bulls fed on six different diets with five of them containing additional fats to achieve a high variability in body lipid composition. When the feed contained fullfat oilseeds (rapeseed, sunflower seed, linseed), the proportions of some nutritionally favourable fatty acids were increased in the patties. Patties made from the meat of bulls fed linseed and coconut oil could be distinguished in a sensory triangle test from most other groups. Cooking loss and instrumental texture properties showed no relation to fatty acid composition of patties. Cooking only slightly decreased the proportion of saturated fatty acids in favour of polyunsaturated fatty acids. In conclusion, widely differing dietary fats can be fed to bulls without risking major effects on texture of beef patties. 相似文献